tetano
Editor, Senior Moderator
Drugs
. 2020 May 25.
doi: 10.1007/s40265-020-01321-z. Online ahead of print.
The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
Nadia Panera[SUP] 1 [/SUP], Alberto Eugenio Tozzi[SUP] 2 [/SUP], Anna Alisi[SUP] 3 [/SUP]
Affiliations
Abstract
G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.
. 2020 May 25.
doi: 10.1007/s40265-020-01321-z. Online ahead of print.
The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
Nadia Panera[SUP] 1 [/SUP], Alberto Eugenio Tozzi[SUP] 2 [/SUP], Anna Alisi[SUP] 3 [/SUP]
Affiliations
- PMID: 32451923
- DOI: 10.1007/s40265-020-01321-z
Abstract
G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.