tetano
Editor, Senior Moderator
Drugs Context. 2020 Apr 28;9. pii: 2020-4-5. doi: 10.7573/dic.2020-4-5. eCollection 2020.
Chloroquine and hydroxychloroquine in the context of COVID-19.
Shukla AM[SUP]1,[/SUP][SUP]2[/SUP], Archibald LK[SUP]1,[/SUP][SUP]2[/SUP], Shukla AW[SUP]3[/SUP], Mehta HJ[SUP]2[/SUP], Cherabuddi K[SUP]2[/SUP].
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Abstract
Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. This review aims to present the available in vitro and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment.
Copyright ? 2020 Shukla AM, Archibald LK, Wagle Shukla A, Mehta HJ, Cherabuddi K.
KEYWORDS:
COVID-19; SARS-CoV-2; anti-inflammatory; antimalarial; antiviral; chloroquine; hydroxychloroquine; immunomodulatory; pandemic
PMID:32373183PMCID:PMC7192209DOI:10.7573/dic.2020-4-5
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Chloroquine and hydroxychloroquine in the context of COVID-19.
Shukla AM[SUP]1,[/SUP][SUP]2[/SUP], Archibald LK[SUP]1,[/SUP][SUP]2[/SUP], Shukla AW[SUP]3[/SUP], Mehta HJ[SUP]2[/SUP], Cherabuddi K[SUP]2[/SUP].
Author information
Abstract
Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. This review aims to present the available in vitro and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment.
Copyright ? 2020 Shukla AM, Archibald LK, Wagle Shukla A, Mehta HJ, Cherabuddi K.
KEYWORDS:
COVID-19; SARS-CoV-2; anti-inflammatory; antimalarial; antiviral; chloroquine; hydroxychloroquine; immunomodulatory; pandemic
PMID:32373183PMCID:PMC7192209DOI:10.7573/dic.2020-4-5
Free full text