tetano
Editor, Senior Moderator
Drug Discov Today
. 2021 Jan 22;S1359-6446(21)00041-6.
doi: 10.1016/j.drudis.2021.01.014. Online ahead of print.
SARS-CoV-2-mediated hyperferritinemia and cardiac arrest: preliminary insights
Prakash VasanthiDharmalingam[SUP] 1 [/SUP], Vengadeshprabhu Karuppagounder[SUP] 2 [/SUP], Kenichi Watanabe[SUP] 3 [/SUP], Harry Karmouty-Quintana[SUP] 4 [/SUP], Suresh S Palaniyandi[SUP] 5 [/SUP], Ashrith Guha[SUP] 6 [/SUP], Rajarajan A Thandavarayan[SUP] 7 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic that began in China, was first noted in December 2019 {AuQ: Edit OK?}. SARS-CoV-2 infects through the angiotensin-converting enzyme-2 (ACE-2) receptor and co-receptors. In the most severely affected patients, it can cause {AuQ: Edit OK?} pneumonia and multiple organ failure leading to death. Reports describe high death rates resulting from cardiac dysfunction, a co-morbid condition in SARS-CoV-2 patients, while the primary cause and mechanisms remain unknown. Here, we attempt to review clinical reports of SARS-CoV-2 patients in order to provide insight into a possible mechanism that allows hyperferritinemia (the presence of excess iron-binding protein) to cause cardiac dysfunction in SARS-CoV-2 patients. Such insights are an important avenue towards understanding the mechanism of cardiac dysfunction in SARS-CoV-2 patients and developing remedies for the same.
. 2021 Jan 22;S1359-6446(21)00041-6.
doi: 10.1016/j.drudis.2021.01.014. Online ahead of print.
SARS-CoV-2-mediated hyperferritinemia and cardiac arrest: preliminary insights
Prakash VasanthiDharmalingam[SUP] 1 [/SUP], Vengadeshprabhu Karuppagounder[SUP] 2 [/SUP], Kenichi Watanabe[SUP] 3 [/SUP], Harry Karmouty-Quintana[SUP] 4 [/SUP], Suresh S Palaniyandi[SUP] 5 [/SUP], Ashrith Guha[SUP] 6 [/SUP], Rajarajan A Thandavarayan[SUP] 7 [/SUP]
Affiliations
- PMID: 33493677
- DOI: 10.1016/j.drudis.2021.01.014
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic that began in China, was first noted in December 2019 {AuQ: Edit OK?}. SARS-CoV-2 infects through the angiotensin-converting enzyme-2 (ACE-2) receptor and co-receptors. In the most severely affected patients, it can cause {AuQ: Edit OK?} pneumonia and multiple organ failure leading to death. Reports describe high death rates resulting from cardiac dysfunction, a co-morbid condition in SARS-CoV-2 patients, while the primary cause and mechanisms remain unknown. Here, we attempt to review clinical reports of SARS-CoV-2 patients in order to provide insight into a possible mechanism that allows hyperferritinemia (the presence of excess iron-binding protein) to cause cardiac dysfunction in SARS-CoV-2 patients. Such insights are an important avenue towards understanding the mechanism of cardiac dysfunction in SARS-CoV-2 patients and developing remedies for the same.