tetano
Editor, Senior Moderator
Drug Discov Today
. 2023 Apr 5;103579.
doi: 10.1016/j.drudis.2023.103579. Online ahead of print.
COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease
Thales Kronenberger[SUP] 1 [/SUP], Stefan A Laufer[SUP] 2 [/SUP], Thanigaimalai Pillaiyar[SUP] 3 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the causative factor behind the 2019 global coronavirus pandemic (COVID-19). The main protease, known as M[SUP]pro[/SUP], is encoded by the viral genome and is essential for viral replication. It has also been an effective target for drug development. In this review, we discuss the rationale for inhibitors that specifically target SARS-CoV-2 M[SUP]pro[/SUP]. Small molecules and peptidomimetic inhibitors are two types of inhibitor with various modes of action and we focus here on novel inhibitors that were only discovered during the COVID-19 pandemic highlighting their binding modes and structures.
Keywords: Antiviral; COVID-19; Coronavirus; Protease inhibitors; SARS-CoV-2.
. 2023 Apr 5;103579.
doi: 10.1016/j.drudis.2023.103579. Online ahead of print.
COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease
Thales Kronenberger[SUP] 1 [/SUP], Stefan A Laufer[SUP] 2 [/SUP], Thanigaimalai Pillaiyar[SUP] 3 [/SUP]
Affiliations
- PMID: 37028502
- PMCID: PMC10074736
- DOI: 10.1016/j.drudis.2023.103579
Abstract
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the causative factor behind the 2019 global coronavirus pandemic (COVID-19). The main protease, known as M[SUP]pro[/SUP], is encoded by the viral genome and is essential for viral replication. It has also been an effective target for drug development. In this review, we discuss the rationale for inhibitors that specifically target SARS-CoV-2 M[SUP]pro[/SUP]. Small molecules and peptidomimetic inhibitors are two types of inhibitor with various modes of action and we focus here on novel inhibitors that were only discovered during the COVID-19 pandemic highlighting their binding modes and structures.
Keywords: Antiviral; COVID-19; Coronavirus; Protease inhibitors; SARS-CoV-2.