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Draft genome of the first case of mpox virus detected in Kenya, August 2024 - Virological

Mary Wilson

Well-known member
Aug 22​ (2024)
10d
slangat

On 29 July 2024, the Kenyan Ministry of Health confirmed a case of mpox in Taita Taveta County which borders Tanzania (Mpox – African Region 1). The reported case was from a 42-year-old male, a long-distance truck driver who had travelled from Kampala, Uganda to Mombasa, Kenya and was enroute to Rwanda at the time of detection. The date of onset of symptoms was 3 July 2024 and the case was detected and isolated by the Kenyan Ministry of Health officials on 22 July 2024 after presenting with classic symptoms of mpox infection. Here, we report the rapid application of unbiased metagenomic next generation sequencing (mNGS) to reconstruct the genome sequence of this mpox case in Kenya. The protocol under which the sample was obtained and processed for qPCR and sequencing is approved by the Kenya Medical Research Institute’s Scientific Ethics and Review Unit (SERU) under study number; SSC3035. ...


The following individuals are leading this work:
Ministry of Health – Kenya: Emmanuel Okunga, Daniel Langat and Patrick Amoth.
Kenya Medical Research Institute (KEMRI): Konongoi Limbaso, Victor Ofula, Samoel Khamadi and Elijah Songok.
Chan Zuckerberg Biohub (US): Genay Pilarowski and Paul Oluniyi.​

https://virological.org/t/draft-gen...-mpox-virus-detected-in-kenya-august-2024/976
 

Krutika Kuppalli, MD FIDSA
@KrutikaKuppalli

Genome from #Kenya of the first clade Ib #mpox case: - On 29 July 2024,
@MOH_Kenya
confirmed a mpox case in Taita Taveta County. - The person, a 42-year-old truck driver, traveled from Kampala, #Uganda to Mombasa, Kenya, en route to #Rwanda. - Symptoms began 3 July 2024; the case was detected and isolated on 22 July 2024 after presenting with classic mpox symptoms. - The Kenyan case clusters with clade Ib MPXV strains linked to the ongoing outbreak in the DRC. - Like other clade Ib strains, the Kenyan strain carries APOBEC3-type mutations. - This underscores the need for surveillance to prevent the spread of this MPXV strain. https://virological.org/t/draft-genome-of-the-first-case-of-mpox-virus-detected-in-kenya-august-2024/976…
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8:48 PM · Sep 2, 2024
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