tetano
Editor, Senior Moderator
Dose Response
. 2021 Apr 29;19(2):15593258211011335.
doi: 10.1177/15593258211011335. eCollection Apr-Jun 2021.
Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice
Rufeng Lu[SUP] 1 [/SUP], Yueguo Wu[SUP] 2 [/SUP], Honggang Guo[SUP] 3 [/SUP], Zhuoyi Zhang[SUP] 1 [/SUP], Yuzhou He[SUP] 1 [/SUP]
Affiliations
Abstract
Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, the effects of salidroside on influenza A virus-induced ALI were investigated in a murine model. BALB/c mice were intranasally inoculated with H1N1 virus and treated with salidroside. The results of this study show that salidroside treatment (30 and 60 mg/kg) significantly attenuated the H1N1 virus-induced histological alterations in the lung and inhibited inflammatory cytokine production. Salidroside also decreased the wet/dry ratio, viral titers, and Toll-like receptor 4 expression in the lungs. Therefore, salidroside may represent a potential therapeutic reagent for the treatment of influenza A virus-induced ALI.
Keywords: Toll-like receptor 4; acute lung injury; inflammatory cytokines; influenza A virus; salidroside.
. 2021 Apr 29;19(2):15593258211011335.
doi: 10.1177/15593258211011335. eCollection Apr-Jun 2021.
Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice
Rufeng Lu[SUP] 1 [/SUP], Yueguo Wu[SUP] 2 [/SUP], Honggang Guo[SUP] 3 [/SUP], Zhuoyi Zhang[SUP] 1 [/SUP], Yuzhou He[SUP] 1 [/SUP]
Affiliations
- PMID: 34017230
- PMCID: PMC8114266
- DOI: 10.1177/15593258211011335
Abstract
Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, the effects of salidroside on influenza A virus-induced ALI were investigated in a murine model. BALB/c mice were intranasally inoculated with H1N1 virus and treated with salidroside. The results of this study show that salidroside treatment (30 and 60 mg/kg) significantly attenuated the H1N1 virus-induced histological alterations in the lung and inhibited inflammatory cytokine production. Salidroside also decreased the wet/dry ratio, viral titers, and Toll-like receptor 4 expression in the lungs. Therefore, salidroside may represent a potential therapeutic reagent for the treatment of influenza A virus-induced ALI.
Keywords: Toll-like receptor 4; acute lung injury; inflammatory cytokines; influenza A virus; salidroside.