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Donors flood in for blood drive to save critically ill

AlaskaDenise

In Memoriam
A landmark study to determine whether blood from patients who recovered from human swine flu (H1N1) can be prepared as "a treatment of last resort" for critically ill flu patients this winter has attracted 40 volunteers in less than 48 hours.

This comes as the Hospital Authority yesterday said people with flu-like symptoms who turn up at accident and emergency departments should not expect to be automatically tested for H1N1 or treated with antiviral drug Tamiflu.

More than 800 of 8,000 recovered flu victims are being recruited to give blood so that a special swine flu vaccine can be extracted and administered to 63 critically ill patients. Another 63 will be given a "simple immunoglobulin" - which primes immunity but is not specific to human swine flu.

Researcher Ivan Hung Fan-ngai, who is a clinical assistant professor of medicine at Hong Kong University, said: "We had a very good response: 30 to 40 patients who recovered told us they will donate their blood. We are calling donors up instead of them calling us, otherwise it will be chaotic."

He said the donors' ethnicity does not matter, so long as they are Hong Kong identity card holders.

David Hui Sui-cheong, a specialist in respiratory medicine at Chinese University who is not involved in the study, said serum collected from swine flu patients who have recovered will work "if the pandemic becomes aggressive."

He added: "It provides another option for more severe cases."

An association of pharmacists said yesterday people are buying Tamiflu from various sources and warned that using it without consulting doctors could do more harm than good.

Godfrey Lui Ming-fung, vice president of the Practising Pharmacists Association, said he was aware of "people buying Tamiflu from the internet or the black market. In some cases, patients [buy] from unregistered dispensaries."

The side effects of indiscriminate use of Tamiflu could include suicidal tendencies, especially among young people, digestive disorders, or bleeding, he said.

President Iris Jacqueline Chang said with schools opening next week, parents should teach their children about personal hygiene, which is important to prevent catching flu.

http://www.thestandard.com.hk/news_detail.asp?pp_cat=11&art_id=87043&sid=25171202&con_type=1
 
Re: Donors flood in for blood drive to save critically ill

This option has been discussed here at FT or 3 years now. It will be quite interesting to watch the outcome.

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Re: Donors flood in for blood drive to save critically ill

But there is a large difference here. There is no shortage of H1N1 survivors floating around to use as potential donors, as a result of the widespread nature of the pandemic, as well as the low CFR. Hong Kong also used antibodies from recovered patients to treat SARS patients in 2003.

But for H5N1, there are few survivors due to the higher CFR, and for SARS there were few survivors due to the (fortunately) limited spread.

This H1N1 virus will serve as an interesting test for this procedure, but it would be foolish to conclude if it works here that it could be successfully used in a higher CFR pandemic.
 
Re: Donors flood in for blood drive to save critically ill

.....This H1N1 virus will serve as an interesting test for this procedure, but it would be foolish to conclude if it works here that it could be successfully used in a higher CFR pandemic.

My comments were directed toward H1N1.

A higher CFR H1N1 outbreak should still be treatable (subject to availability) via this method, as long as the antigens don't undergo significant change.

Read Mamabird's comments here: http://www.flutrackers.com/forum/showpost.php?p=286660&postcount=15

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Re: Donors flood in for blood drive to save critically ill

I agree with you as far as H1N1 goes. The antibodies from current survivors could be used to treat severe cases in a (possible) future wave of higher CFR.
 
Re: Donors flood in for blood drive to save critically ill

I really admire the scientists and citizens of HK for taking this alternative from theoretical to reality. :applause:

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Re: Donors flood in for blood drive to save critically ill

They treated a case with H5N1 on the mainland in this way a few years ago.
She survived.
 
Re: Donors flood in for blood drive to save critically ill

This is one reason further testing to confirm cases is important. There is a much bigger group available with the correct antibodies. AD I agree with you wholeheartedly. This is a very brave move and may well pave the way to an unsophisticated approach to a dire situation.

And GS - there is no talk of paying donors! ;)
 
Re: Donors flood in for blood drive to save critically ill

Source: http://www.thestandard.com.hk/news_detail.asp?pp_cat=11&art_id=87108&sid=25199812&con_type=1

Victim dies after blood fix fails
Mary Ann Benitez
Monday, August 31, 2009

Hong Kong's human swine flu (H1N1) death toll climbed to five yesterday when last-ditch efforts to save a 43-year-old woman by giving her the blood serum of a recovered patient failed.

It is thought to be the first time that the blood - or convalescent - serum of someone who survived swine flu has been used on a patient in Hong Kong.

In late July, doctors tried in vain to save a critically ill woman using an artificial lung machine. The latest victim was a "chronic smoker" who did not have any other underlying disease.

She developed flu symptoms on August 23 and went to a designated flu clinic run by the Hospital Authority the following day.

Last Wednesday, she went to Tuen Mun Hospital's accident and emergency department and was admitted to the isolation ward. The test for pandemic H1N1 flu returned positive hours later.

It was only after confirmation that the woman was given the antivirals Tamiflu and Relenza and antibiotics. Her condition worsened quickly and she was transferred to intensive care later that day and put on a ventilator.

"Her condition continued to deteriorate and convalescent serum was given on August 29. She died at 12.17am," the hospital said yesterday.

So far, there have been 51 severe cases of pandemic H1N1 reported in Hong Kong, with five deaths. A total of 21 critically ill patients have made a full recovery. Eleven remain critically ill in hospitals, including a new case involving an 18-year-old woman at Prince of Wales Hospital.

David Hui Sui-cheong, a specialist in respiratory medicine at Chinese University, said the Tuen Mun Hospital case could be the first time that convalescent serum had been tried to save a swine flu patient here. At the height of the SARS crisis in 2003 around 100 patients received convalescent serum. "We had very good results because convalescent serum contains the neutralizing antibodies and so it is a very good adjunct therapy," Hui said.

He added that smokers were particularly at risk of severe symptoms because the pandemic flu virus infects the lungs directly.

"If doctors have a strong suspicion of a case of severe human swine flu, they should use Tamiflu straight away. If the patient has a risk factor or severe disease, you do not wait for the [confirmatory test] results," Hui said.

As of yesterday, the number of confirmed cases stood at 11,578, with 331 new cases comprising 176 males and 155 females, aged between five months and 84 years.

On Saturday, the World Health Organization said: "Clinicians around the world are reporting a very severe form of the disease, also in young and otherwise healthy people, which is rarely seen during seasonal influenza infections."
 
Re: Donors flood in for blood drive to save critically ill

Shiloh #9 text:

"last-ditch efforts to save a 43-year-old woman by giving her the blood serum of a recovered patient failed."

"The latest victim was a "chronic smoker" who did not have any other underlying disease."

"She developed flu symptoms on August 23 and went to a designated flu clinic run by the Hospital Authority the following day.

Last Wednesday, she went to Tuen Mun Hospital's accident and emergency department and was admitted to the isolation ward. The test for pandemic H1N1 flu returned positive hours later.

It was only after confirmation that the woman was given the antivirals Tamiflu and Relenza and antibiotics. Her condition worsened quickly and she was transferred to intensive care later that day and put on a ventilator.

"Her condition continued to deteriorate and convalescent serum was given on August 29. She died at 12.17am," the hospital said yesterday."
 
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