tetano
Editor, Senior Moderator
Infect Genet Evol. 2014 Jan 23. pii: S1567-1348(14)00017-3. doi: 10.1016/j.meegid.2014.01.014. [Epub ahead of print]
Diverse inter-continental and host lineage reassortant avian influenza A viruses in pelagic seabirds.
Huang Y1, Robertson GJ2, Ojkic D3, Whitney H4, Lang AS5.
Author information
Abstract
Avian influenza A viruses (AIVs) often infect waterfowl, gulls and shorebirds, but other bird groups including pelagic seabirds also serve as hosts. In this study, we analyzed 21 AIVs found in two distant breeding colonies of Common Murre (Uria aalge) in Newfoundland and Labrador, Canada, during 2011. Phylogenetic analyses and genotype assignments were performed for the 21 Common Murre viruses together with all Common and Thick-billed Murre (U. lomvia) AIV sequences available in public sequence databases. All fully characterized viruses from the Common Murres in 2011 were H1N2 subtype, but the genome sequences revealed greater diversity and the viruses belonged to four distinct genotypes. The four genotypes shared most segments in common, but reassortment was observed for PB2 and M segments. This provided direct genetic data of AIV diversification through segment reassortment during an outbreak of AIV infection in high-density breeding colonies. Analysis of the total collection of available murre viruses revealed a diverse collection of subtypes and gene lineages with high similarity to those found in viruses from waterfowl and gulls, and there was no indication of murre-specific AIV gene lineages. Overall, the virus gene pool in murres was predominantly made up of AIV lineages associated with waterfowl, but also featured considerable inter-continental and gull lineages. In particular, all but one of the 21 Common Murre viruses from 2011 in Newfoundland contained 1 or 2 Eurasian segments and 16 contained 1 gull lineage segment. This mosaic nature of characterized murre AIV genomes might reflect an under-recognized role of these pelagic seabirds in virus transmission across space and between bird host taxa.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Genome sequence, Murre, Reassortment, Virus transmission
PMID:
24462905
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24462905
Diverse inter-continental and host lineage reassortant avian influenza A viruses in pelagic seabirds.
Huang Y1, Robertson GJ2, Ojkic D3, Whitney H4, Lang AS5.
Author information
Abstract
Avian influenza A viruses (AIVs) often infect waterfowl, gulls and shorebirds, but other bird groups including pelagic seabirds also serve as hosts. In this study, we analyzed 21 AIVs found in two distant breeding colonies of Common Murre (Uria aalge) in Newfoundland and Labrador, Canada, during 2011. Phylogenetic analyses and genotype assignments were performed for the 21 Common Murre viruses together with all Common and Thick-billed Murre (U. lomvia) AIV sequences available in public sequence databases. All fully characterized viruses from the Common Murres in 2011 were H1N2 subtype, but the genome sequences revealed greater diversity and the viruses belonged to four distinct genotypes. The four genotypes shared most segments in common, but reassortment was observed for PB2 and M segments. This provided direct genetic data of AIV diversification through segment reassortment during an outbreak of AIV infection in high-density breeding colonies. Analysis of the total collection of available murre viruses revealed a diverse collection of subtypes and gene lineages with high similarity to those found in viruses from waterfowl and gulls, and there was no indication of murre-specific AIV gene lineages. Overall, the virus gene pool in murres was predominantly made up of AIV lineages associated with waterfowl, but also featured considerable inter-continental and gull lineages. In particular, all but one of the 21 Common Murre viruses from 2011 in Newfoundland contained 1 or 2 Eurasian segments and 16 contained 1 gull lineage segment. This mosaic nature of characterized murre AIV genomes might reflect an under-recognized role of these pelagic seabirds in virus transmission across space and between bird host taxa.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Genome sequence, Murre, Reassortment, Virus transmission
PMID:
24462905
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24462905