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Discussion thread VII - COVID-19: Endemic Stage

https://www.livemint.com/opinion/co...america-remains-a-mystery-11663782717702.html
Who is still dying from covid in America remains a mystery

4 min read . Updated: 21 Sep 2022, 11:26 PM ISTFaye Flam, Bloomberg
The pandemic’s not fully over and fatality risks are very confusing
...

Topol has also shared concerns about our lack of information. Not only do we lack detailed information on how many (if any) vaccine shots they’ve had, we also lack data on what treatments they received. “Did they get Paxlovid? Did they get bebtelovimab?" he asked in a daily paper. (Bebtelovimab is a monoclonal antibody treatment.)

Even if vaccines vastly reduce risk, it doesn’t follow that anti-vaxxers are the root of the problem. It’s possible for vaccines to be very protective but still see fully vaccinated people die, simply because younger unvaccinated people face less risk than fully vaccinated seniors. One reason clear data isn’t available is that the US doesn’t collect that information in a uniform way, said Stephen Kissler, a researcher at the Harvard School of Public Health. “A lot of public health happens at city level or lower so, because of that, it’s really hard to combine data across states to assess who is ending up in the hospital or dying of covid," he said. “The mix is hard to standardize." Another challenge has to do with the complex immunological landscape, he said. It’s not just a matter of how many boosters people have that determines their level of protection, but when they’ve gotten them. Add to that the fact that the most vulnerable people are more likely to get vaccinated.

There’s another deceptive factor that can make it look like everyone is in pretty good shape, said Andrew Noymer, associate professor of public health at the University of California, Irvine. The infection fatality rate, a number many were obsessed with finding early in the pandemic, is probably now close to that of flu. But the disease is killing a lot more people than flu because so many people are getting covid. It’s now common for people to get it several times a year, which is far more often than the flu.

Even public health experts who are furious with Biden for his remarks have had to concede they were wrong in claiming that we’d “crush" the pandemic if only enough people followed the rules, stayed locked down or masked up for 100 days. “When this first arrived, we thought this would be a nightmare for six months and it would go away because we’d all have immunity," said Noymer. “That hasn’t panned out."

What Americans need is not to keep hearing the word ‘pandemic’ but to get some clarity about what we should be doing. We don’t all share the same values, but we should at least have the chance to argue over the same data.

Faye Flam is a Bloomberg Opinion columnist covering science
 
Citizens in nursing homes and hospitals have the same human rights as the rest of us. Decisions are theirs and theirs alone, unless they are mentally incapacitated, then decisions should be made by family or designated medical powers of attorney. Institutions should never have the power to isolate us from our advocates and family.
 
Most people in nursing homes are medically frail. This is why they are there. Masking mandates for staff would help them. Let's not lose sight of reasonableness.
 
yes, I'm missing the data by vaccination status _and natural infection
just a small sample, an estimate. Who has it ?
 
gs I remembered that the end points were primary - disease, and secondary - severe disease for the mRNA trials so I went back and looked at the exact wording of the FDA phase 3 trial protocol. The primary end point was 'lab confirmed COVID' technically COVID is symptomatic disease, as apposed to SARS-Cov-2 viral infection, so I tried to find if they were testing those with symptoms, or just routinely screening everyone at regular intervals and calling all PCR positive samples COVID, but could not find a definitve answer. The secondary end point is a lot simpler as they have a list of clinical criteria.
 
Wikipedia gives effectiveness against symptomatic and asymptomatic.disease
No big difference.

https://en.wikipedia.org/wiki/Pfizer–BioNTech_COVID-19_vaccine#Effectiveness
92,92 (alpha) , 92,94(Wuhan) , 79,83 (delta) 2 doses

https://en.wikipedia.org/wiki/Moderna_COVID-19_vaccine#Effectiveness
--,90(alpha) --,93(Wuhan) 54,74 (delta) 2 doses

95% efficacy were the headlines in the news and stockprices
went up a lot. That's what I remembered when posting 95%..
Here is the paper:
https://pubmed.ncbi.nlm.nih.gov/33301246/
 
I think in the US it will take legal action to get data on vaccines. But we might be able to get a better handle on these persistent deaths attributed to Covid if we compare mortality data from pre-pandemic times. I'm wondering if we'd see less people dying of old age related conditions now because they are dying with Covid from those conditions? The data might be here, but I haven't figured out how to get at what I want yet.
https://wonder.cdc.gov/ucd-icd10.html
 
this is all being examined. USA has good mortality statistics data.
Now also weekly at CDC :
here my USA-death-links
:
US,deaths : https://data.cdc.gov/api/views/y5bj-...ue% 20target=
USA weekly deaths by cause 2014-2019
https://data.cdc.gov/api/views/3yf8-...ue&format=true
USA provisional deaths 2020-2022
https://data.cdc.gov/api/views/muzy-...ue&format=true
USA deaths by 12quarter,22cause,age+State+ : https://data.cdc.gov/NCHS/NCHS-VSRR-...sele/489q-934x

HMD has weekly deaths from all causes by 5 agegroups and 37 countries
(some weeks delay)

people at twitter and elsewhere are examing this
actuaries,professors,journalists
 
This is NOT medical advice. If you have any medical questions consult your medical practitioner.


Going into this fall I am still doing everything I can to prevent COVID-19. So far I have not contracted it (to my knowledge). Still:

1. I wear a clean 95N mask indoors.

2. No inside restaurants or other inside entertainment venues.

3. No crowds.

4. Directed trips to inside areas like the grocery store. I do not casually shop the store. I have a list and know what I am getting ahead of time.

5. Carry hand sanitizer packets in my purse. Carry liquid hand sanitizer in the cup holders of my car.

6. Wipe down or spray everything coming into the house.

7. My animals are not allowed to be in contact with any other animals.


I do not care what people think. I plan to venture out frequently to outside venues as the weather becomes less humid but I will still avoid crowded situations.

I have not taken the new revised booster shot yet. I might get it. I have not decided. I did get the original two shots and followed with two boosters.

I posted because I want to support people who do not want to get COVID-19 and are still trying to prevent infection. COVID-19 is endemic and it has not magically disappeared.

I have never supported government mandated lockdowns, masks, vaccines, etc. for the general population. However, I do think people in congregate settings, like nursing homes, need to be protected.

Thank you for viewing and take care of yourself. :)


I am the only person wearing an N95 mask indoors when I go anywhere. It is such an easy thing to do - especially for only an hour. I do not understand.

Even mild cases of COVID-19 are causing problems for people. For example:


Nature Medicine - Long-term neurologic outcomes of COVID-19

snip

"In conclusion, our report provides a comprehensive analysis of neurologic outcomes at 12 months. We show increased risk of an array of neurologic disorders spanning several neurologic disease categories including stroke (both ischemic and hemorrhagic), cognition and memory disorders, peripheral nervous system disorders, episodic disorders, extrapyramidal and movement disorders, mental health disorders, musculoskeletal disorders, sensory disorders, and other disorders including Guillain–Barré syndrome, and encephalitis or encephalopathy.

The risks were evident in all examined subgroups and were evident even in people who were not hospitalized during the acute phase of the disease..."


https://flutrackers.com/forum/forum...ine-long-term-neurologic-outcomes-of-covid-19
 
These were VA patients, mostly white men, with an earlier variant: positive COVID-19 test between 1 March 2020 and 15 January 2021. With all the statistical manipulations in that article, I didn't get a sense of what the real risk to that population group was at the time, let alone to someone like me if I didn't have some immunity already.
It is a problem for some people to wear a mask, especially an N95, for an hour. I did an experiment and took my resting pulse with and without a mask, (one of those suffocating, stupid cloth masks I wore early on), and my pulse was 10 pts higher with the mask on. I assume that my heart had to work harder to try to oxygenate my blood.
I did not feel well wearing a mask shopping or at a museum. I only wear a N95 mask now for brief periods when exposed to wood smoke and I don't care what people think about that.
 
I'm reasonable. It's inhumane to force healthy workers to wear masks all the time. Where is the data that mandatory masking of staff, let alone their visitors, would improve QOL or mortality of residents? And my main point was about isolating patients from family for any reason.
 
Hope they can get some good analysis done. I realized the CDC Wonder database only goes through 2020, so I couldn't compare what I wanted. I did figure out how to do deaths per 100K for vascular dementia, but can't see if that or other typical causes of death in old age show a pattern between pre-pandemic and now.
 
State Surgeon General Dr. Joseph A. Ladapo Issues New mRNA COVID-19 Vaccine Guidance

Florida Department of Health sent this bulletin at 10/07/2022 06:12 PM EDT [TABLE="align: center, border: 0, cellpadding: 0, cellspacing: 0"]
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[TD]State Surgeon General Dr. Joseph A. Ladapo Issues New mRNA COVID-19 Vaccine Guidance


TALLAHASSEE, Fla. – Today, State Surgeon General Dr. Joseph A. Ladapo has announced new guidance regarding mRNA vaccines. The Florida Department of Health (Department) conducted an analysis through a self-controlled case series, which is a technique originally developed to evaluate vaccine safety.

This analysis found that there is an 84% increase in the relative incidence of cardiac-related death among males 18-39 years old within 28 days following mRNA vaccination. With a high level of global immunity to COVID-19, the benefit of vaccination is likely outweighed by this abnormally high risk of cardiac-related death among men in this age group. Non-mRNA vaccines were not found to have these increased risks.

As such, the State Surgeon General recommends against males aged 18 to 39 from receiving mRNA COVID-19 vaccines. Those with preexisting cardiac conditions, such as myocarditis and pericarditis, should take particular caution when making this decision.

“Studying the safety and efficacy of any medications, including vaccines, is an important component of public health,” said Surgeon General Dr. Joseph Ladapo. “Far less attention has been paid to safety and the concerns of many individuals have been dismissed – these are important findings that should be communicated to Floridians.”

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https://content.govdelivery.com/acco...letins/3312697
 
Ok. So, if someone does not want to take any vaccines for COVID-19, or wear any N95 masks, then what? Just pretend covid is nothing and get the infection over and over, and hope for the best? Not me.
 
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