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Discussion thread VII - COVID-19: Endemic Stage


Neena Jha
@DrNeenaJha
·
2h
It’s over.

Any control over Covid we had is over.

Duty doctor today. I’ve lost count of the number of patients I’ve seen with classic Covid symptoms

NOT A SINGLE PERSON has isolated or done a PCR test. Everyone’s mixing & infecting each other. There is no control. It’s over.
 
Translation Google

Has Covid-19 become a "normal" disease?

Interview by Idèr Nabili
Posted on March 31, 2022 at 9:04 a.m., updated on March 31, 2022 at 9:38 a.m.

THE ESSENTIAL

For several days, all the indicators have been on the rise in France.

At the same time, most restrictions were dropped.

Is Covid-19 on its way to becoming an ordinary disease? Professor Antoine Flahault responds to TF1info.

Will we soon be talking about Covid-19 as we talk about the flu, gastroenteritis or angina? For several days, new contaminations have started to rise again, while the vaccination pass has been suspended and most barrier measures set aside. Spain has even gone further by removing the quarantine requirement for mild cases. Has Covid-19 become an ordinary disease? Professor Antoine Flahault, director of the Institute of Global Health in Geneva (Switzerland), enlightens us.

New cases are increasing, restrictions are decreasing... Should we see this as a sign of a return to normal life?

Everyone would like it. But the Omicron variant is not less virulent: in Hong Kong , where the fragile population is poorly vaccinated, it creates a disaster. In Europe, hospitals are not saturated, as the continent is currently reaping the benefits of vaccination. This gives the impression of the end of the pandemic. If welcome, this respite may be short-lived, since no one knows the next variant.

With the end of the mask, we could observe a greater number of serious forms
Professor Antoine Flahault

Should Covid-19 be treated like the flu?

Covid-19 is not the flu. I don't know of any flu that causes in France, for several months in a row, between 100 and 300 deaths per day and as many hospitalizations in intensive care. We are therefore very far from the consequences of the flu, especially since long Covids are still poorly understood, and several experts fear that this will become a major chronic disease problem. On the contrary, we remain in a sneaky pandemic, with a virus that mutates very often.

So Covid-19 cannot become an ordinary disease?

The World Health Organization still defines Covid-19 as a public health emergency of international concern. It is therefore not at all a disease like the others. Note that we have no other diseases that have such an impact on the social, economic and political life of the entire planet. We are faced with an extremely mild disease in a very large number of people, but which can be daunting because it can clog hospitals. This is completely new, we are far from a "normal" disease.

Should the barrier measures therefore continue?

Abandoning them represents risk-taking, especially for vulnerable people. But let's not forget that the Omicron variant was a game changer . This strain has led democratic countries to no longer take strong measures to fight against its progression, but only to fight against serious forms, with vaccination or the wearing of a mask. Indeed, if the mask slightly reduces the transmission of the virus, its main objective is to reduce the infectious viral load in the air. With the mask, a person becomes infected with much less viral load than if everyone takes it off. Due to the end of the obligation in the indoor environment, it is possible that we observe a greater number of serious forms.

Interview by Idèr Nabili

https://www.tf1info.fr/sante/epidem...rmale-interview-antoine-flahault-2215229.html
 
This type of evidence of possible brain involvement from COVID-19 is why I got the 4th shot yesterday. I am at high risk for a bad outcome from the disease. I switched to Pfizer for added diversity. This is my choice only and not meant to be medical advice. So far I have a slightly sore injection site.

If you have any medical questions, please consult your medical practitioner. Do not take medical advice from the internet.

----------------------------------------------------------------------------------



IleneRuhoyMDPhD
@RuhoyMD
Neurocovid tidbits from the annual neurology conference. Standing room only for this lecture. Virus presumably enters brain via cribriform plate But despite lots of viral particles in the nasal mucosa multiple brain biopsy studies show no viral particles in brain.
6:35 PM · Apr 2, 2022·Twitter for iPhone
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IleneRuhoyMDPhD
@RuhoyMD
·
10h
Replying to
@RuhoyMD
Congested blood vessels and microhemorrhages seen in brain 7T MRI studies shows thickened vessel walls, clots and microhemorrhages in sane vessel 11T MRI studies of pons found high levels of fibrinogen deposition and activated platelets, macrophages leading to neuronophagia
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IleneRuhoyMDPhD
@RuhoyMD
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PECAM 1 staining shows activated endothelial cells (endothelial injury) but also deposition of IgG and IgM hence thought to be immune mediated. Many have antiphospholipid antibodies. Vestibular symptom immune mediated vasculitis.
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IleneRuhoyMDPhD
@RuhoyMD
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T cell and cytokine mediated disease Cranial nerve and spinal root involvement Lots of macrophages in the vessels Persistence of activated macrophages (due to fibrinogen) Lymphocytes in perivascular regions Dedifferentiated monocytes in CSF Evidence of T cell exhaustion
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IleneRuhoyMDPhD
@RuhoyMD
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10h
#longcovid F>M Immune mediated Usually mild sxs that initially improved but then recurred Brain fog - mood, sleep, cognitive Exercise intolerance Looks like mecfs Pots, SFN, dysautonomia
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IleneRuhoyMDPhD
@RuhoyMD
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Symmetric decreased uptake of glucose on FDG-PET Serial MRIs in UK study show total intracranial volume decrease and hippocampus gyrus volume decreased
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IleneRuhoyMDPhD
@RuhoyMD
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Immune mediated attack of blood vessels Activated macrophages chew up neurons Lots of biomarker suggestions for neuronal and vascular injury. And so much more…(gotta go to the next lecture)
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IleneRuhoyMDPhD
@RuhoyMD
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Impressed by the number of studies, interest, and clinics opening. #neurology
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Please see these recent studies:


Curr Opin Neurol . Neurocognitive and psychiatric post-coronavirus disease 2019 conditions: pathogenic insights of brain dysfunction following severe acute respiratory syndrome coronavirus 2 infection

CIDRAP - Study reveals some brain changes, even in mild COVID-19

Nature: SARS-CoV-2 is associated with changes in brain structure in UK Biobank

BMC Infect Dis . Severe Post-COVID-19 dysautonomia: a case report

Dev Med Child Neurol . Neurological effects of COVID-19 in infants and children

JMA J . Pathologic and Neuropathologic Study of a Case of COVID-19

Med Arch . Ischemic Vasculitis as a Cause of Brain Disorder's in Patients with Long Covid: Case Report

Acta Neuropsychiatr . Relationships between the Fear of COVID-19 Scale and regional brain atrophy in mild cognitive impairment

Brain Behav Immun Health . Neuropsychological functioning in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve

BMC Infect Dis . Persistent, new-onset symptoms and mental health complaints in Long COVID in a Brazilian cohort of non-hospitalized patients

Arch Clin Neuropsychol . Neurocognitive Profiles in Patients With Persisting Cognitive Symptoms Associated With COVID-19
 
Aging. It happens to the best of us.

https://www.nature.com/articles/s41467-022-29440-z
"Notably, the animals in this study were of advanced age, which is associated with a higher risk for the development of cerebrovascular disease among infected patients8. Indeed, aging, itself, is the greatest risk factor for cerebrovascular disease, due, at least in part to age-related changes of cerebral vascular structure and/or function that contribute to reduced cerebral blood flow, which may be further compounded by underlying vascular pathology35,36. This may predispose the aging vasculature to cerebrovascular events, particularly in the context of prolonged systemic inflammation and hypoxemia, which have been shown to contribute to increased vascular permeability through microglia and astrocyte responses37,38."
 
Could be the disease (very delayed effects), could be the vaccine, could be stress.

https://finance.yahoo.com/news/analy...140016010.html
Analysis: Deaths surged across California in 2021. The rural High Desert took a heavy hi
Charlie McGee, Victorville Daily Press
Mon, April 4, 2022, 7:04 PM

....

In turn, health authorities group the rarest causes of death into one category dubbed, “All other diseases (Residual).” This category mixes myriad unique ailments ranging from “systemic atrophies primarily affecting the central nervous system” to inflammation throughout the body to various “diseases of the blood and blood-forming organs.”

Between 2014 and 2018, these deaths remained at a stagnant up-and-down in the area of 24,000 deaths in California, then ticked up to just above 25,000 in 2019.

In 2020, the uncommon-cause category spiked by more than 12% to about 28,250 deaths.

Then, “all other diseases” surged another 4% to a total of more than 29,350 deaths last year, as of CalViDa’s latest count.
 
https://igorchudov.substack.com/p/uk-covid-becoming-chronic-like-aids?s=r
UK: Covid Becoming CHRONIC, like AIDS, and Will Take us Down

Bye Bye, "Vaccine Immunity" and "Hybrid Immunity".
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I would like to discuss very disturbing statistics from the UK, that clearly shows that Covid is becoming a chronic disease, in the same sense as AIDS is a chronic disease. Covid, for many Brits, is an illness that will just not go away. Endless bouts, recurrence, or even never-ending disease, is now the norm and not the exception, and will lead to a catastrophe.
Covid, now a “chronic disease” that makes people ill continuously or very frequently, is completely opposed to “endemic disease”, like colds, that would make people ill for just a few days a year.
Before I go further, let me point out again that I am NOT trying to badmouth the splendid United Kingdom. It is a wonderful country with rich culture, incredible people, and OUTSTANDING STATISTICAL AGENCIES. It is the latter that let me show the disaster unfolding there. People of the UK are diverse, and are not biologically very different from people in other countries. What I write about the UK, applies to any other highly vaccinated Western country...
 
Coronavirus FAQ: I'm a one-way masker. With mask mandates going away, is that helpful?

Updated April 19, 20221:17 PM ET
WILL STONE
...
It can be lonely out there as the solo masker in a sea of exposed chins and noses.
...
But if you plan to continue wearing a mask, you can still get substantial protection as the sole mask-wearer if you do it right.
...
Pick the best mask
...
"The only thing I recommend is something like an N95 respirator," says Lisa Brosseau, a bioaerosol scientist and industrial hygienist who's a consultant for the University of Minnesota's Center for Infectious Disease Research and Policy.
...
Of course, any kind of protection is better than nothing at all. If you have no other options, surgical masks are better than cloth masks because the material has electrostatic charge to trap incoming particles, says Abraar Karan, an infectious disease physician at Stanford University — but if you're serious, don't count on them to keep you safe when most people nearby are unmasked.
...
But keep in mind that an N95 on its own isn't foolproof.
...
Even with a solid choice like an N95, you need to calculate the risks you'll face as a one-way masker.

"Just wearing a mask — it helps, but it is not going to turn being indoors into something that has no risk," says Jose-Luis Jimenez, a professor at the University of Colorado Boulder and an aerosols scientist.
...
Poorly ventilated indoor spaces, especially where people are talking loudly, singing or exercising, carry the highest risk. If you do go inside, the safest situation is an uncrowded venue. And the longer you spend indoors, the more you open yourself up to infection.

The final big risk consideration comes down to how many people are contagious in your community. Dr. Lisa Maragakis says you can look at the number of new cases per capita in your community over the past week.

"That number needs to be in the single digits — somewhere between one to five cases per 100,000...

And remember: There are no hard-and-fast rules.

For example, you can spend the same amount of time in similar indoor spaces, but the chance of infection can go up enormously depending on what people are doing.

"We've seen tons of outbreaks in choirs, none in libraries and movie theaters that I know of," says Jimenez, who has developed a tool that estimates risk in different scenarios.
...
One recent modeling study found a 90% risk of being infected after 30 minutes when a person wears a surgical mask and is about 5 feet away from an infected unmasked person. Switching to a respirator drops that risk to 20% over the course of an hour. And if both people are wearing a respirator, it's under 1% in an hour.

Brosseau has also analyzed this kind of scenario, although with a different approach that looks at how long it would take to get a big enough "dose" of the virus that you'd likely be infected. She found it would be about an hour and 15 minutes for someone wearing an N95 (not fit tested) to get infected when in close contact with a contagious person.
...
https://www.npr.org/sections/goatsan...imal-protectio
 
it's so easy and straightforward to create new COVID-variants

I wonder why this hasn't already happened , or has it ?
It's clearly a big threat.

But noone is talking about it. Strange.

And then also it will be easy soon (or is already) to create entirely new pandemic viruses
by manipulating and combining existing viruses
 
gsgs said:
it's so easy and straightforward to create new COVID-variants

I wonder why this hasn't already happened , or has it ?
It's clearly a big threat.

But noone is talking about it. Strange.

And then also it will be easy soon (or is already) to create entirely new pandemic viruses
by manipulating and combining existing viruses
Click to expand...

They are not talking about it because they are hoping no one notices.
 
I hope they are preparing. With secret , WHO-approved GOF-research, how to build
more transmissable but less virulent variants so to counter
new threats.
The "spreading vaccine". Much faster than normal vaccine.
I think we talked about this wrt. H5N1 decades ago.
 
Marty Makary MD, MPH
@MartyMakary

Surprised to learn that Kamala Harris who is asymptomatic, healthy, and quadruple vaccinated is getting Paxlovid, a drug reserved for high-risk patients per the FDA label.

9:20 AM · Apr 27, 2022·Twitter for iPhone

Related to:

US - White House statement: Vice President has tested positive for COVID-19 - asymptomatic - April 26, 2022

https://flutrackers.com/forum/forum/...-april-26-2022
 
Dr. Anthony Fauci walks back comment about US no longer being in ‘pandemic phase’

By Mark Lungariello
April 27, 2022 6:46pm

Dr. Anthony Fauci walked back his comment that the US was no longer in the “pandemic phase” of COVID-19....

Biden administration officials and Fauci were scrambling Wednesday to emphasize that the country is still in the midst of a pandemic and that emergency measures are still needed after Fauci told PBS the precise opposite.

“Here we are. It’s the end of April. It’s the spring of 2022. How close are we to the end of the pandemic?” Judy Woodruff of “PBS NewsHour” asked Fauci Tuesday.

“We are certainly, right now, in this country out of the pandemic phase,” Fauci replied. “Namely, we don’t have 900,000 new infections a day and tens and tens and tens of thousands of hospitalizations and thousands of deaths. We are at a low level right now.

“So, if you’re saying, are we out of the pandemic phase in this country, we are,” he added.

A day later, after his comments made headlines worldwide, Fauci was singing a different tune. “We are in a different moment of the pandemic,” Fauci told the Associated Press Wednesday. The US has “decelerated and transitioned into more of a controlled phase” after a winter surge, he added.

“By no means does that mean the pandemic is over,” Fauci said in his 180-degree turnabout.
...
https://nypost.com/2022/04/27/dr-fauci-walks-back-comment-about-us-no-longer-in-pandemic-phase/
 
There are some really horrible scenes of the lockdowns in China on twitter. The problem is that FluTrackers has no way to verify anything. Plus - twitter is banned in China. So who are these accounts? Are these snips from movies with a new audio overlay? Or are they real?

From what I have seen that is realistic is that China uses all manner of blockades - including locking/welding people into their houses and apartments. Also, it appears that food and medicine deliveries can be a real problem.

The quarantine warehouse-like buildings are real. People can be (and many are) required to stay there if they test positive and/or are exposed to people who tested positive.

I have also seen credible videos in the past where desperate people fell from several stories above ground trying to leave their apartment.

Of course - welding and/or placing bars at windows and doors to buildings is extremely dangerous.

I have to wonder what the leaders are thinking. I have two words.

Regime.

Change.
 
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