• FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster. The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website. By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
  • We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.

Discussion thread VII - COVID-19: Endemic Stage

Danish data offers hope the COVID-19 pandemic is ending, but experts warn it's not quite over yet

By business reporter Michael Janda
Posted 1h ago

Since the start of the pandemic, sceptics of the severity of COVID-19 have likened it to the flu.

That is the view of JP Morgan economist David Mackie, who has been doing statistical analysis of the pandemic since soon after it began.

"Our analysis of the Danish data suggests that the properties of the now dominant BA.2 sub-lineage of Omicron (high transmissibility but low virulence), high vaccination and booster rates and the use of anti-viral therapeutics have together pushed the case fatality rate (CFR) of COVID-19 to below the CFR of influenza," he noted.

He believes Denmark, which last week removed most restrictions, could offer an insight into what the COVID endemic that is likely to follow the pandemic might look like.

This is possible, Mr Mackie argued, because the CFR, or death rate, in Denmark from those confirmed to have the BA.2 strain of Omicron, now dominant there, is less than 0.05 per cent — or one-in-2,000.

Mr Mackie said this is similar to the global death rate from influenza, which is estimated to kill between 0.05-0.1 per cent of those infected.

However, he added that it is likely the fatality rate from Omicron BA.2 is lower still, because people who die within 30 days of a positive test are recorded as a COVID-19 death.

"A University of Copenhagen study calculated that up to 40 per cent of the deaths recorded in the latest week in Denmark were people who died with COVID-19 rather than people who died because of COVID-19," he noted.

"If we make this adjustment, the CFR for BA.2 falls from 0.045 per cent to 0.027 per cent."

At this level, while Mr Mackie believes COVID-19 will still result in millions of extra hospitalisations around the world each year than before it existed, he thinks governments are more likely to invest in their healthcare systems to respond than impose restrictions on individual behaviour.
...
https://www.abc.net.au/news/2022-02-...emic/100814004
 
Source: https://bariweiss.substack.com/p/revenge-of-the-covid-moms

Revenge of the Covid Moms
'This is the year that parents say: You’re either with us or against us.’
Suzy Weiss
Feb 8

Maud Maron hates the whole you-gotta-show-your-vaccine-passport-to-get-into-a-restaurant thing, and she thinks masking indoors is atrocious, but this is bright blue New York City, so fine. It’s just, “when Kathy Hochul”—the governor—“gets on the screen, talking about how she wants to protect us and keep the masks in schools, she doesn’t have a fucking mask on her face, and I’m so sick of politicians who take the mask off their face to tell me to put the mask on my children—like how dare you?” Anyway, that’s why she’s running for Congress.

We’re having tea around her kitchen island in her apartment in Soho. It’s big. There’s a ping pong table, a foosball table, a swing bolted into a wooden beam. A bright red, toddler-sized race car. A tattered copy of “Romeo and Juliet.” Speech-therapy exercises are tacked to the wall. Her husband, who’s Argentinian, runs a private-equity shop. “When you shut down my kids' schools and impose devastating mental health effects on them—I don’t forgive anyone who did that,” Maron says.

After a beat or two, she adds: “This is the year that parents say, ‘You’re either with us or against us.’”

Maron is running in New York’s 12th congressional district against Carolyn Maloney, a Democrat who has served for nearly 30 years representing both the 12th and 14th districts. Maloney, 75, turned heads at last year’s Met Gala dressed in a suffragette-themed purple, white, and green gown while mask-clad attendants stood by drearily in the wings. She’s warded off challengers from the left-wing of the party for the past few terms; 28-year old Democratic Socialist Rana Abdelhamid is her latest progressive challenger. But the Democrats’ newly-unveiled redistricting plan out of Albany cuts out leftier enclaves in Brooklyn and Queens from her district.

That’s good news for Maloney. But it’s potentially even better for Maron—and all the other moms lined up behind her.

Natalya Murakhver, an Upper West Side mom of two, heard Maron at an open-the-schools rally in March 2021. By Murakhver’s count there have been five such rallies over the past two years. There was no waiting for the politicians—“they were completely disinterested in responding to our calls”—so she sued New York in April to force the city to reopen.Then she launched #MaskLikeAKid, which was all about unmasking children. Then, in October, Megyn Kelly had Murakhver on her show to talk about all the angry moms out there. With Maud Maron. “I was a very liberal Democrat,” Murakhver told me. “Now, my vote is up for grabs to whoever puts kids first.”

Ditto Vanessa Steinkamp. Steinkamp now lives in the Dallas suburbs, by way of New Orleans and Chicago. She’s 45, a teacher, a mom of three, and a politically homeless Never Trump Republican. When Covid hit, she says, it was like everyone forgot the kids. Now they are the only thing that matters.

“Hell hath no fury like an angry mom,” Steinkamp says. In 2019, she ran unsuccessfully for the City Council. She’s thinking of running again...
 
New Zealand protest at Parliament in Wellington....seems to be a few hundred with some blocking of the streets. Very unusual display for New Zealanders.

 
I found some positive opinions on "fishform" masks, so I looked it up and ordered some at $1 per mask.
People claimed better fit, comfort, less fogged glasses, but some complained about breaking elastic bands.
They claim for 99^ which would be FFP3 but only FFP2=N95 is approved.
Then they claim for self-disinfection by copper-nanoparticles.
We had this with flu-masks (copper or silver ?) and as I remember, it didn't hold up

these:ones ; https://duckduckgo.com/?q=masks+fishform&t=ffab&iax=images&ia=images
 
the same (surprising, sudden, rare) accumulation of amino-acid changes happened
in alpha and delta , so I'd expect a similar mechanism.
But they didn't find mouse-origin-mutations there

-------------------------------------------------------------------
abstract
The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled
its outbreak raises questions as to whether its proximal origin occurred in humans or
another mammalian host.
Here, we identified 45 point mutations that Omicron acquired since divergence from
the B.1.1 lineage.
We found that the Omicron spike protein sequence was subjected to stronger positive
selection than that of any reported SARS-CoV-2 variants known to evolve persistently
in human hosts, suggesting a possibility of host jumping.
The molecular spectrum of mutations (i.e., the relative frequency of the 12 types of base
substitutions) acquired by the progenitor of Omicron was significantly different from the
spectrum for viruses that evolved in human patients but resembled the spectra associated
with virus evolution in a mouse cellular environment.
Furthermore, mutations in the Omicron spike protein significantly overlapped with
SARS-CoV-2 mutations known to promote adaptation to mouse hosts,
particularly through enhanced spike protein binding affinity for the mouse cell entry receptor.
Collectively, our results suggest that the progenitor of Omicron jumped from humans
to mice, rapidly accumulated mutations conducive to infecting that host,
then jumped back into humans, indicating an inter-species evolutionary trajectory
for the Omicron outbreak

...
p.3
We further identified mutations in the other four SARS-CoV-2 VOCs (i.e.,
Alpha, Beta, Gamma, and Delta) as well as those in the SARS-CoV-2
variants isolated from three chronically infected patients
(Kemp et al., 2021; Truong et al., 2021), but did not observe such a level
of overrepresentation of mutations in ORF S or RBD region as in the
pre-outbreak Omicron mutations (Fig. 1B).
 
2.) for seasonal colds - it's mainly rhinovirus. I don't know, whether they looked specifically at corona
4.) I mean those experts who do the sequencing. Rambaut etc. we had watched SARS2-mutations
until Dec2020 and nothing happened . But then -whoom- came alpha.
Without any intermediate in the number of aa-changes
5.)+6.) well, it was in multiple Chinese provinces already with community spread and onlt single cases
outside China. I didn't expect they could contain it (despite their optimism...)
until about Feb05-Feb10. The problem was mainly Wuhan and Hubei, in other
provinces it was quickly controlled. So, why couldn'r we do that ?
 
gs I would argue that the premise in both of the linked papers are interesting but inconclusive. I think the pre-Omicron variants are just pre-existing variants which were not fit enough to become dominant until the mass vaccination campaign, and weight of prior infections, changed the population immune profile to their advantage. The vaccines became available at the end of 2020 and ramped up through 2021. Alpha showed up at about the same time and was globally dominant from March to June 2021 and Delta dominated from July to Dec. The other VOC were much more regional and never gained global dominance (see https://covariants.org/per-variant ). They each had a little under 25 NS mutations about 10 in S and the rest distributed across the other proteins (relative to the ancestral strain) however Alpha has only 3 S and 1 other change from its direct ancestor. Omicron is quantitatively different having 36 NS in S and a further 26 elsewhere it is also throwing up a lot of minor variants plus being phylogenitically rooted in an older dormant lineage, all of which make me think it is not just a variant that has been undetected while it slowly morphed into its epidemic form but gained them rapidly in an immunocompromised host or in an un-sampled non human population. The rate of change, now that it is in a normal human immune environment, would imply rapid adjustment to that system.

re. your earlier question "The problem was mainly Wuhan and Hubei, in other
provinces it was quickly controlled. So, why couldn'r we do that ?"
We probably could, in practical terms, but it was not politically possible. Look at the current Canadian situation and all they are being asked to do is get vaccinated not having entire cities locked down tight and guarded to enforce compliance.
 
I am not sure what the logic is here. Meanwhile mandate protests are taking place in many places including New Zealand. (Not a political post. I have no insight into what the parties are in Canada). Political leaders should cooperate with each other to diffuse the situation - for the sake of public health.




Travis Dhanraj

@Travisdhanraj
·
9m
#BREAKING: For 3rd time
@fordnation
gov’t has declined to participate in a meeting this aft of trilateral table set up by the feds to deal with the ongoing blockades in Ontario. A source w/ province telling
@CBCNews
“it doesn’t accomplish anything” #cdnpoli #onpoli
95
350
338

-------------------------------------------------------
 
Source: https://bariweiss.substack.com/p/what-the-truckers-want

What the Truckers Want
I’ve spoken to 100 of the protestors gathered in the Canadian capital. What's happening is far bigger than the vaccine mandates.
Rupa Subramanya
12 hr ago

For two weeks, the 18-wheelers, the semis, the tractors and the pick-up trucks streamed through the snow and ice into the center of Ottawa, the Canadian capital.

They came from across the country. Vaxxed, unvaxxed, white, black, Chinese, Sikh, Indian, alone or with their wives and kids. They huddled around campfires. They set up pop-up kitchens and tents with block captains doling out coffee and blankets. They honked (and honked and honked). They blasted “We Are the World.” And everywhere you looked, someone was waving the Maple Leaf.

It dipped to 4 degrees. The mayor declared a state of emergency. And they didn’t budge.

The truckers were scared of running out of gas—freezing to death in their little truck beds in the middle of the night. The city threatened to arrest anyone who brought it to them. In response, hundreds of Ottawans did just that. The truckers stayed put.

They are a city inside a city whose inhabitants—there are an estimated 8,000 to 10,000—were outraged with a country that seemed to have forgotten they existed. This past Sunday, as if to confirm that suspicion, Prime Minister Justin Trudeau, who has yet to meet with Freedom Convoy leaders, took a personal day. On Monday, during an emergency debate at the House of Commons, he called them “a few people shouting and waving swastikas.”

​​I live in downtown Ottawa, within view of Parliament Hill, and have spent the past 10 days or so bundled up and walking around the protests. I have spoken to close to 100 protesters, truckers and other folks, and not one of them sounded like an insurrectionist, white supremacist, racist or misogynist. ..
 
Some aggressive US interventionists are encouraging violence in Canada and want the US government (DHS) to get involved in the trucker protest in Canada. (I guess they are running out of other countries to turn into hellscapes.)

https://twitter.com/juliettekayyem/status/1491789181428715521
https://web.archive.org/web/2022021...com/juliettekayyem/status/1491789181428715521

Juliette Kayyem
@juliettekayyem

@Harvard prof, @CNN
Analyst & CEO of Grip Mobility. Nat'l security expert, former Obama @DHSgov
.



Juliette Kayyem
@juliettekayyem·
19h

The convoy protest, applauded by right wing media as a "freedom protest," is an economic and security issue now. The Ambassador Bridge link constitutes 28% of annual trade movement between US and Canada. Slash the tires, empty gas tanks, arrest the drivers, and move the trucks



Juliette Kayyem
@juliettekayyem
17h

Trust me, I will not run out of ways to make this hurt: cancel their insurance; suspend their drivers licenses; prohibit any future regulatory certification for truckers, etc. Have we learned nothing? These things fester when there are no consequences.
 
Not surprised that a Harvard grad didn't realize that slashed tires and empty gas tanks will make it really difficult to move the trucks out of the way.
 
Violence is out. Do not listen to anyone who advocates violence, destruction of property, harm against others, etc.
 
Back
Top