Discussion : my crystal ball.....

[Toaster2]

Behind a paywall. I remember the duscussions with Henry Niman. The conclusion was probably no recombination in bird flu.

but what are the implications for recombination of Covid ? Can SarsCov2 also recombine, and with which other (corona) viruses ?

 

[sharon sanders]

Behind a paywall. I remember the duscussions with Henry Niman. The conclusion was probably no recombination in bird flu.

but what are the implications for recombination of Covid ? Can SarsCov2 also recombine, and with which other (corona) viruses ?

The article is based on this paper:

Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens

Stephen A. Goldstein, View ORCID ProfileJoe Brown, Brent S. Pedersen, Aaron R. Quinlan, View ORCID ProfileNels C. Elde
doi: https://doi.org/10.1101/2021.02.03.429646

This article is a preprint and has not been certified by peer review [what does this mean?].

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Abstract


The ongoing SARS-CoV-2 pandemic is the third zoonotic coronavirus identified in the last twenty years. Previously, four other known coronaviruses moved from animal reservoirs into humans and now cause primarily mild-to-moderate respiratory disease. The emergence of these viruses likely involved a period of intense transmission before becoming endemic, highlighting the recurrent threat to human health posed by animal coronaviruses. Enzootic and epizootic coronaviruses of diverse lineages pose a significant threat to livestock, as most recently observed for virulent strains of porcine epidemic diarrhea virus (PEDV) and swine acute diarrhea-associated coronavirus (SADS-CoV). Unique to RNA viruses, coronaviruses encode a proofreading exonuclease (ExoN) that lowers point mutation rates to increase the viability of large RNA virus genomes, which comes with the cost of limiting virus adaptation via point mutation. This limitation can be overcome by high rates of recombination that facilitate rapid increases in genetic diversification. To compare dynamics of recombination between related sequences, we developed an open-source computational workflow (IDPlot) to measure nucleotide identity, locate recombination breakpoints, and infer phylogenetic relationships. We analyzed recombination dynamics among three groups of coronaviruses with impacts on livestock or human health: SARSr-CoV, Betacoronavirus-1, and SADSr-CoV.

We found that all three groups undergo recombination with highly diverged viruses, disrupting phylogenetic relationships and revealing contributions of unknown coronavirus lineages to the genetic diversity of established groups. Dynamic patterns of recombination impact inferences of relatedness between diverse coronaviruses and expand the genetic pool that may contribute to future zoonotic events. These results illustrate the limitations of current sampling approaches for anticipating zoonotic threats to human and animal health.

Competing Interest Statement


The authors have declared no competing interest.


https://www.biorxiv.org/content/10.1101/2021.02.03.429646v1

 

[bertrand789]

Enfin, un peu de vrai, mais les r?servoirs identifi?s et d?crits ne le sont pas ...


Donc ce serait bien que la d?marche one health soit mise en oeuvre l? ou cela commence presque ? chaque fois, non ?

Dit autrement, les C.D.C , c'est bien, mais bon on arrive ? ?teindre bien des feux, sans eux, non ?

Pour arriver ? entrevoir et mettre en oeuvre la vraie d?marche, c'est s?r, qu'avec l'organisation de l'O.M.S actuelle



on n'a aucune chance

on se met au boulot quand ?