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?None of this surprising,? Osterholm said. ?What has been unfortunate is this debate for the last month of whether the link is proven or unproven. We had clear evidence for public health officials to take action a month ago.?
http://www.forbes.com/sites/tarahae...uses-microencephaly/#2715e4857a0b7ffd83520e62. . . It?s unclear whether these findings would necessarily change much in terms of policy measures, especially since the link was already so strongly suspected. It also does not mean that every pregnant woman who becomes infected with Zika will definitely give birth to a baby with serious problems. In Slate, Melinda Wenner Moyer offers a reality check for those in freak-out mode: The actual threat of microcephaly from cases of Zika in pregnancy may not be high. We don?t have good data on the risk yet. . .
.?There?s a lot of basic work and research that we need to do,? says Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases in Bethesda, Maryland.?There?s a lot of basic work and research that we need to do.?It?s plausible, for instance, that Zika crosses from mother to baby through the placenta, as do some related viruses, such as West Nile virus. But these other viruses don?t often cause infant brain damage, so it?s not clear why ? or how ? Zika might, says David Morens, a senior adviser to Fauci.
Soares de Ara?jo JS, Regis CT, Gomes RGS, Tavares TR, Rocha dos Santos C,
Assun??o PM, et al. Microcephaly in northeast Brazil: a review of 16 208 births
between 2012 and 2015 [Submitted]. Bull World Health Organ E-pub: 4 Feb 2016. doi:
http://dx.doi.org/10.2471/BLT.16.170639
...
...However, the temporal fluctuation was documented since late 2012, before the allegedly
entry of the ZIKV in Brazil, in mid-2014...
...
These observations highlight the need to review the situation carefully. Many questions
need to be answered prior to concluding what problem we are facing, how it came about
and which consequences it is likely to bring to the Brazilian population in years to
come.
...
Many other potential factors need to be considered as the cause of the outbreak. Among
them figures the possibility of boosting effects from associated infections, perhaps even
viral infections, such as DENV and CHIKV, both carried by the same Aedes aegypti
vector. Also to be considered is teratogens exposure, such as vaccines or drugs used in
early pregnancy.(1,2) Further, malnutrition, which has previously been associated to
microcephaly, could have an intensifying effect when coupled with other aetiological
factors. Indeed, most of the reported cases have occurred in low-income families...
Dr. Tom Frieden @DrFriedenCDC 3h3 hours agoHousehold exposure to pesticides and bladder exstrophy in a
newborn baby boy: a case report and review of the literature
Marlene Martin1, Kristina Rodriguez1, Miguel S?nchez-Sauco1,
Gerardo Zambudio-Carmona2 and Juan Antonio Ortega-Garc?a1*
Addresses: 1Pediatric Environmental Health Specialty Unit and 2Pediatric Surgery and Urology, Hospital University Virgen de la Arrixaca,
Carretera Madrid-Cartagena 30120 El Palmar, Murcia, Spain
Email: MM - marlenemartin@gmail.com; KR - kmrodriguez06@gmail.com; GCZ - gzambudio@uropediatria.com; JAOG* - ortega@pehsu.org
* Corresponding author
Published: 30 March 2009 Received: 1 July 2008
Accepted: 22 January 2009
Journal of Medical Case Reports 2009, 3:6626 doi: 10.1186/1752-1947-3-6626
This article is available from: http://jmedicalcasereports.com/jmedicalcasereports/article/view/3/3/6626
? 2009 Martin et al; licensee Cases Network Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction: Bladder exstrophy is a rare urogenital abnormality. Other urogenital malformations
have been associated with exposure to hormonal pesticide disruptors during critical developmental
periods. This is the first report in the literature to associate household exposure to pesticides with
bladder exstrophy.
Case presentation: We describe the pediatric environmental history of a newborn baby boy with
isolated bladder exstrophy. In this case the pediatric environmental history includes the
constitutional, genealogical, genetic and environmental factors related to bladder exstrophy, which
revealed a cockroach infestation in the parents? home and the daily use of bug spray to kill them. The
mother used one bottle of spray every 2 days (1000cc) and more in the summer, when the problem
was worse. During gestational weeks 0-12, the mother intensively used a domestic pesticide
consisting of a mixture of pyrethroids (cyfenothrin 0.5%, and tetramethrin 0.31%) and pyriproxyfen
(0.01%). She described repeated episodes of mild to moderate poisoning that are associated with the
use of household pesticides. The mother is a housewife and the father works as a fumigator of fruit
fields and he reported gastrointestinal symptoms associated with the use of occupational pesticides.
However, he did not believe he carried traces of these products into the home and his wife washed
his work clothes separately. The pyrethroids and pyriproxyfen were detected in a urine sample
obtained from the child 4 months after he was born. No other risk factors were identified.
Conclusions: A detailed and carefully conducted pediatric environmental history, which includes
information about home pesticide use, should be carried out for all children with bladder exstrophy.
Domestic exposure to pesticides during critical developmental periods may have deleterious effects
for the fetus.
...
It is difficult to attribute a cause to a condition when so
many factors remain unknown. Despite the apparent lack
of conclusive evidence, we should err on the side of
caution and apply our scientific knowledge to protect
current and future generations. It is important to give
specific pest control recommendations to eliminate or
diminish the pesticides used at home. In addition, we
must remember to look for alternatives to ionizing
radiation during pregnancy and only conduct radiologic
examinations during the first postmenstrual week in any
woman of childbearing age. The PEH not only helps
register the RFs involved but also to improve the home
environment and quality of life.
熱帯医学 Tropical medicine 35(4). p331-334, 1994
...
Furthermore, I should like to point out that careful studies are necessary to confirm
non-toxicity or non-teratogenicity in humans of drinking water containing pyriproxyfen
when it is used for a long period of time.
However, increase in the number of microcephaly were found in Polynesia only after the outbreak of Zika.
Ian Mackay interviewed an expert at the University of Queensland on the larvicide controversy:
"....The potential human health consequences of discouraging the use of pyriproxyfen in drinking water storage and other mosquito-reduction programs is catastrophic with potential deaths and serious disease from otherwise avoidable malaria, dengue and other mosquito-borne diseases numbered in at least the hundreds of thousands. If these reports and suggestions are motivated by anything other than ignorance and poor scholarship they are deserving of the most strident condemnation.
Journalists covering this story would do well to research the background of those making and reporting the claims as the underlying story and potential public health consequences may be far more newsworthy than the current headlines"
http://virologydownunder.blogspot.com.au/2016/02/debugging-recent-claim-that.html
Directors Dr. Medardo Avila Vazquez, a pediatrician and neonatologist, UNC professor of Medicine and Coordinator of the Universidatia Network Environment and Health / Me'dicos fumigated Peoples
Li. Miryam Gorban, Lic. In Nutrition, Professor of Public Lecture on Food Sovereignty of the Fac. Of Medicine UBA.
Doctor who testified for chemical-industry front group gives up his license
May 21, 2014| By Sam Roe and Patricia Callahan | Tribune reporters
As one of the nation?s top burn surgeons, Dr. David Heimbach was a perfect choice to enlist as a star witness. His dramatic testimony about babies burned to death in furniture fires helped convince lawmakers they shouldn?t scale back use of flame retardants.
But the stories weren?t true, and the organization backing him turned out to be a chemical industry front group.
This week, facing disciplinary charges in the state of Washington, Heimbach surrendered his medical license.
State officials had alleged that Heimbach, whose activities were exposed in a 2012 Tribune investigation, fabricated testimony and falsely presented himself as an unbiased burn expert when, in fact, he had been paid $240,000 for his help.
Heimbach and manufacturers have defended flame retardants, which are added to furniture cushions, despite research that shows they don?t provide any meaningful protection from home fires.
Heimbach?s decision to surrender his license, made public Wednesday, represents a stunning fall. For 25 years, Heimbach was head of the burn center at Harborview Medical Center in Seattle and was a longtime surgery professor at the University of Washington. He once received an award from the Dalai Lama for his care of burn victims around the world.
But he could not withstand the most serious charge against him: telling lawmakers false stories of babies who suffered fatal burns while on cushioning that lacked flame retardants. The infants, as he described them, did not exist....
Sumaia Villela - Correspondent Agency Brazil
- 02/15/2016 17:15 publication
- Recife location
Faced with the controversy over the pyriproxifen larvicide, the city of Recife said today (15) who has never used the substance to combat the Aedes aegypti mosquito, which transmits dengue, chikungunya fever and Zika virus. The use of pyriproxifen was suspended by the Rio Grande do Sul government on Saturday (13), on the grounds that the substance may be related to the occurrence of microcephaly in babies.
The Ministry of Health and the manufacturer of larvicide have spoken in defense of the product, which is distributed by the Brazilian government for vector disease control, including the Aedes aegypti.
The Recife has the largest number of child births notifications with suspected microcephaly across the country. 258 residents are babies in Recife recorded by the health service. Of this total, 40 were confirmed in 26 cases the malformation was discarded. The rest is under investigation.
Until 2001, the Recife wore Temefos larvicide and, from 2002, began to employ a biological substitute the basis of Bacillus thuringiensis israelensis (BTI).
According to Secretary of Health of Recife, Jailson Correa, after which it became possible to buy larvicides for bidding, as of 2009, the city opted to use its own resources and continue buying organic produce and no longer use provided by Ministry of Health, which is currently the pyriproxifen.
"The management and the city of Recife at the time assessed that, considering that Recife is a city bathed in rivers, it would be appropriate to maintain a biological larvicide that have less environmental impact," he explains.
According to Correa, the application of BTI is part of the routine actions of the city government agents. The product is placed in the population water reservoirs or possible Aedes aegypti breeding sites that are difficult to be eliminated. After application, the substance has 40 days of action.
[h=3]Know more[/h]
- RS suspends use of larvicide pyriproxyfen in combating Aedes
- Microcephaly: Ministry of Health defends security larvicide
Unlike the capital, several municipalities of Pernambuco use pyriproxifen, which led the State Department of Health to also manifest on the subject. In a statement, the agency said that "there are cases of microcephaly in places that do not use pyriproxifen larvicide for years, as in many places where its use is often no records of cases."
The department argues that the use of pyriproxifen is approved by the World Health Organization (WHO) and there are no epidemiological studies showing an association with the product "microcephaly or any mutagenic effect, genotoxic, carcinogenic, teratogenic or neurotoxic."
Today, more than 7700 soldiers sent to Pernambuco to strengthen the fight against Aedes aegypti are already on the street making visits to homes and businesses and applying larvicides in potential insect breeding sites. Since December, the work of environmental surveillance agents had already been reinforced by members of the armed forces.
Misunderstanding
The suspension of pyriproxifen in Rio Grande do Sul was enacted based on a technical note of Public Health Brazilian Association (Abrasco), that, in assessing the state government, the product relates to the occurrence of microcephaly. However, the organization says that there was a misunderstanding and that never associated the use of pyriproxifen the malformation.
"There's been a misunderstanding. In our technical note not put this relationship in question, that is, did not say that the larvicide is associated with microcephaly, "said the Agency Brazil the coordinator of the Group Health and Environment Abrasco, Marcelo Firpo.
According to Firpo, which criticizes the entity is the use of chemicals as the main strategy to fight Aedes aegypti. For Abrasco the problem of focus is different: "The most affected populations are precisely the poorest, structural problems of sanitation, access to clean water. We consider a health nonsense, nonsense poison placing larvicide in drinking water. "
According to Firpo, expand investments in sanitation and distribute safe equipment for water storage are some of the solutions needed to avoid breeding proliferation of Aedes aegypti and other vectors of disease.
* Updated at 17:50 Matter to include the placement of Abrasco
Edition: Luana Louren?o