If you are clinician who is likely to have to deal with COVID patient I would recommend this https://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-2020-0198/cclm-2020-0198.xml (pre-publication) which Tetano (many thanks as always) linked to in today's Sci. library dump. It is a meta analysis of patient lab data which includes a number of parameters which deviate from the norm in those patients that subsequently go on to develop severe disease.
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Discussion - 2019-nCoV therapeutics
- Thread starter JJackson
- Start date
kiwibird
Editor, Senior Moderator
From the Mayo Clinic
But elevated blood urea nitrogen can also be due to:
- Urinary tract obstruction.
- Congestive heart failure or recent heart attack.
- Gastrointestinal bleeding.
- Dehydration, resulting from not drinking enough fluids or for other reasons.
- Shock.
- Severe burns.
- Certain medications, such as some antibiotics.
- A high-protein diet.
High values
A high BUN value can mean kidney injury or disease is present. Kidney damage can be caused by diabetes or high blood pressure that directly affects the kidneys. High BUN levels can also be caused by low blood flow to the kidneys caused by dehydration or heart failure. Many medicines may cause a high BUN.
Elevated Creatinine
Some of the causes of high creatinine levels are:
- Chronic kidney disease. Share on Pinterest Intense exercise can result in increased creatinine levels. ...
- Kidney obstruction. ...
- Dehydration. ...
- Increased consumption of protein. ...
- Intense exercise. ...
- Certain medications.
Emily
Editor, Senior Moderator
Towards the end Annie Sparrow says that Remdesivir trial in China is nearing the end and looks good.
https://www.youtube.com/watch?v=m28UufGwyTw
https://www.youtube.com/watch?v=m28UufGwyTw
kiwibird
Editor, Senior Moderator
Thank you to Gert for this information.
Gert van der Hoek
Editor, Senior Moderator
Via Twitter a messag from Minister of Health Olivier V?ran:
Taking anti-inflammatory drugs (ibuprofen, cortisone, ...) could be a factor in worsening the infection. If you have a fever, take paracetamol.
If you are already on anti-inflammatory drugs or in doubt, ask your doctor for advice.
h/t https://twitter.com/oli3be
Olivier V?ran (@olivierveran) on Twitter
https://twitter.com
Tags: None
Gert van der Hoek
Editor, Senior Moderator
- Join Date: Aug 2006
- Posts: 22552
TweetVia Twitter a messag from Minister of Health Olivier V?ran:
Taking anti-inflammatory drugs (ibuprofen, cortisone, ...) could be a factor in worsening the infection. If you have a fever, take paracetamol.
If you are already on anti-inflammatory drugs or in doubt, ask your doctor for advice.
h/t https://twitter.com/oli3be
Olivier V?ran (@olivierveran) on Twitter
https://twitter.com
Tags: None
bertrand789
Well-known member
ah bon ,
EXCLUSIF - Coronavirus : ? On sait gu?rir la maladie ?, affirme l'infectiologue Didier Raoult
https://www.lesechos.fr/idees-debats...raoult-1186129
https://www.youtube.com/watch?v=n4J8kydOvbc&t=410s
http://didierraoult.com/
EXCLUSIF - Coronavirus : ? On sait gu?rir la maladie ?, affirme l'infectiologue Didier Raoult
https://www.lesechos.fr/idees-debats...raoult-1186129
https://www.youtube.com/watch?v=n4J8kydOvbc&t=410s
http://didierraoult.com/
I asked in an earlier post if anyone knew about TCM (Traditional Chinese Medicine) treatments and trials and there is now a paper covering this. I have so many papers I have downloaded and working through I have only skimmed this one so far but it has tables of what was used, which trials are on going what stage they are up to and if they are randomized or controlled clinical etc.
Seeing as China seems to have got better control of COVID than anyone else and most of their patients (85%) were on some type of TCM I think it is as important to see the results of these as it is to see the results for everything being tried in the west.
Link https://www.ijbs.com/v16p1708.htm
Seeing as China seems to have got better control of COVID than anyone else and most of their patients (85%) were on some type of TCM I think it is as important to see the results of these as it is to see the results for everything being tried in the west.
Link https://www.ijbs.com/v16p1708.htm
It turns out that cortico-steroids may be useful if given at the right time in combination with an IL6 blocker later. If the steroids are given too early they mess up the adaptive immune response but in mid infection they help but the patient may already be heading onto an immune over reaction and if they do not respond then the dampening of the IL6 cytokines slows the recruitment of more damaging neutrophils to the site of infection. Daniel has been trialing various drugs, we are all reading about in the press, in his ICU with marginal benefits but says this works in that it is obvious to see without any trial protocols.
TWiV 598 about 10mins in. https://www.microbe.tv/twiv/
This looks at the adaptive immune response if you need a little more background. https://www.youtube.com/watch?v=28gIJ2rrN7I
TWiV 598 about 10mins in. https://www.microbe.tv/twiv/
This looks at the adaptive immune response if you need a little more background. https://www.youtube.com/watch?v=28gIJ2rrN7I
kiwibird
Editor, Senior Moderator
Emily
Editor, Senior Moderator
This would be a breakthrough in reducing deaths from this illness. A doctor on a Seattle radio station said that about 80% of patients that get the immune dysfuntion bad enough to be ventilated will die. He thought that the immune dysfunction was hitting about 1% of cases. (I think he was talking about cases where people get sick enought to seek care.)
https://flutrackers.com/forum/forum...-19-autoimmune-cytikine-release-syndrome-drug
(cytokine)
https://flutrackers.com/forum/forum...-19-autoimmune-cytikine-release-syndrome-drug
(cytokine)
TWiV 600 is out and excellent, as always. Daniel Griffin has been giving a weekly update on his thoughts based on what is working for his ICU in NY. They have been refining the regime they have been using which he outlined in TWiV 598 (see post 23 above). For clinicians treating COVID patients I would strongly recommend listening.
https://www.microbe.tv/twiv/twiv-600...comment-133943
In addition to the previous treatments they are now looking a D-dimer levels and have concerns about some large clots so are introducing anti-clotting agents. Also Dr. Gattinoni's comments seem pertinent to their findings re. ARDS not being typical and needing a different clinical approach.
https://flutrackers.com/forum/forum/...tress-syndrome
https://www.microbe.tv/twiv/twiv-600...comment-133943
In addition to the previous treatments they are now looking a D-dimer levels and have concerns about some large clots so are introducing anti-clotting agents. Also Dr. Gattinoni's comments seem pertinent to their findings re. ARDS not being typical and needing a different clinical approach.
https://flutrackers.com/forum/forum/...tress-syndrome
sharon sanders
Editor-in-Chief & President
This Cytosorb therapy just approved in US under emergency use authorization ... helps with cytokine storm, webinar tomorrow.
https://cytosorb-therapy.com/en/even...al-experience/
https://cytosorb-therapy.com/en/even...al-experience/
I believe it is 7am EST, that is what clicks up when I go to the start button for tomorrow. And on one site says this ...
Time
Apr 16, 2020 01:00 PM in Amsterdam, Berlin, Rome, Stockholm, Vienna
which I believe is a 6 hour difference to EST. I admit it is not clear though.
Time
Apr 16, 2020 01:00 PM in Amsterdam, Berlin, Rome, Stockholm, Vienna
which I believe is a 6 hour difference to EST. I admit it is not clear though.
kiwibird
Editor, Senior Moderator
Emily
Editor, Senior Moderator
https://www.fool.com/investing/2020/04/16/why-gilead-sciences-stock-is-on-fire-today.aspx
Will need more details on study.
Will need more details on study.
Emily
Editor, Senior Moderator
Emily
Editor, Senior Moderator
https://www.hhs.gov/sites/default/fi...ay1_panel2.pdf
SARS-CoV-2/COVID-19 Medical Countermeasures Task Force
https://insight.jci.org/articles/view/123158
Adjuvanted S glycoprotein Vaccines (JCI Insight. 2019 Feb 21;4(4). pii:
123158
SARS-CoV-2/COVID-19 Medical Countermeasures Task Force
https://insight.jci.org/articles/view/123158
Adjuvanted S glycoprotein Vaccines (JCI Insight. 2019 Feb 21;4(4). pii:
123158
Pathfinder
Editor, Senior Moderator
Translation Google
Covid-19: Covid-Organics, this remedy that Madagascar has validated
04.21.2020,
-
Against the advice of the WHO, the Madagascan president validated the trials for a treatment based on the well-known artemisia plant in the fight against malaria.
The Madagascan president, Andry Rajoelina is convinced of this: Madagascar is holding an effective drug against Covid-19. It is the Covid-Organics developed by the Malagasy Institute of Applied Research and which contains artemisia or Artemisia annua. A fern-like plant from the traditional Chinese pharmacopoeia grown on the Big Island to fight against malaria, against the advice of the WHO. This discovery seems to have had an impact on the decision of the Head of State to deconfinate the three main cities of the country as of Monday, April 20.
A miracle cure?
After announcing ten days ago the existence of a remedy against the coronavirus in Madagascar, the President of the Republic Andry Rajoelina put an end to the suspense. "Today, I officially announce here the success and the good results of the tests of our remedy," he said, "we can say that it gave a conclusive result on the patients of Covid-19 in Madagascar and that it can limit and lessen its effects on the human body. "
It is the first time that a leader has mentioned artemisia. The World Health Organization (WHO) has recognized that certain traditional medicines and remedies "can alleviate the symptoms" of the coronavirus, but recalled that "there is no evidence that these substances can prevent or cure the disease". The organization even voted in 2007 a resolution "which calls for a progressive withdrawal of monotherapies based on oral artemisinin from the markets". Artemisia is banned in several European countries.
Recourse to the traditional pharmacopoeia
The announcement of the first cases of people infected with Covid-19 has caused in Madagascar a great revival of interest in a whole series of medicinal plants or products such as ginger and lemon supposed to cure or, at the very least, protect from virus. In Madagascar, Imra has been working for several weeks on a treatment against Covid-19. The researchers therefore relied on the results obtained with the Covid-Organics already used to fight against malaria.
According to President Rajoelina "the patients treated with Covid-Organics have been cured". "Patients in respiratory distress have been out of the woods and have already been discharged from the hospital," he added. According to the latest report, 121 cases of contamination by Covid-19, including 39 now considered cured, have been officially reported on the Big Island. None caused the death of a patient.
The opportunity for the head of state to castigate the mentality of certain people who do not trust their leaders or their researchers. According to the national press, Covid-Organics could propel Madagascar to the forefront of the international medical scene and even shake up the world of finance. Artemisia is produced mainly in Madagascar, Africa and Asia.
The stakes are high for the African continent, which records 92% of the 445,000 annual deaths from the disease each year and 90% of the 219 million cases worldwide. Inexpensive herbal medicine would be an advantage over the often more expensive, rare or fake drugs.
In five years, several Artemisia Houses, an association which promotes the use of artemisia founded by the Frenchwoman Lucile Cornet-Vernet, have been created in nearly 23 countries on the continent: Senegal, C?te d'Ivoire, Congo and many others. For this association, it is enough to take the plant in herbal tea for seven days for it to cure and prevent malaria.
Warnings against artemisia
Historically, the virtues of artemisia were revealed to Westerners during the Vietnam War. Indeed, the Americans who fought in the rice fields were treated with chloroquine, a synthetic drug. For their part, the Vietnamese had nothing but died in droves of malaria. For the record, some veterans have even declared that malaria is more formidable than the G.I's. The North Vietnamese then called the Chinese to the rescue who provided them with Artemisia annua to treat the Vietnamese fighters. However, the scientific community is concerned about the side effects of artemisia and remains skeptical about its effectiveness.
The National Academy of Medicine in France warns. If the molecule of artemisinin contained in one of the varieties of artemisia is effectively used in the majority of the antimalarial drugs, "it is its association with other molecules which is necessary to effectively cure the disease by delaying the appearance of resistances “, Recalls Professor Sandrine Houz?, parasitologist at the Bichat hospital in Paris. Not all artemisia species contain artemisinin, she says. And, unlike the tablets which guarantee a constant dosage, the concentration of artemisinin contained in the plant varies according to its mode of culture.
The Madagascan president has already indicated that his "remedy" would be prescribed in the form of syrup "to all students to enable them to protect themselves against the pandemic". "We will gradually restore the normal course of life of the population and their livelihoods," said President Rajoelina in a televised speech, "we will start by doing it for half a day, in the morning from 6 am to 1 pm hours ”.
From Monday morning, public transport will resume their service in the capital Antananarivo and in Fianarantsoa (center) and Toamasina (east) and the schools will reopen for certain classes on Wednesday, he said. The inhabitants will however not be able to “leave their city” and their deconfinement will pass by the obligatory port on the public highway of masks which will begin to be distributed as of Monday. Those who do not wear it will be punished with community service, threatened the head of state.
Le Point / MCP, mediacongo.net
https://www.mediacongo.net/article-a..._a_valide.html
Covid-19: Covid-Organics, this remedy that Madagascar has validated
04.21.2020,
-
Against the advice of the WHO, the Madagascan president validated the trials for a treatment based on the well-known artemisia plant in the fight against malaria.
The Madagascan president, Andry Rajoelina is convinced of this: Madagascar is holding an effective drug against Covid-19. It is the Covid-Organics developed by the Malagasy Institute of Applied Research and which contains artemisia or Artemisia annua. A fern-like plant from the traditional Chinese pharmacopoeia grown on the Big Island to fight against malaria, against the advice of the WHO. This discovery seems to have had an impact on the decision of the Head of State to deconfinate the three main cities of the country as of Monday, April 20.
A miracle cure?
After announcing ten days ago the existence of a remedy against the coronavirus in Madagascar, the President of the Republic Andry Rajoelina put an end to the suspense. "Today, I officially announce here the success and the good results of the tests of our remedy," he said, "we can say that it gave a conclusive result on the patients of Covid-19 in Madagascar and that it can limit and lessen its effects on the human body. "
It is the first time that a leader has mentioned artemisia. The World Health Organization (WHO) has recognized that certain traditional medicines and remedies "can alleviate the symptoms" of the coronavirus, but recalled that "there is no evidence that these substances can prevent or cure the disease". The organization even voted in 2007 a resolution "which calls for a progressive withdrawal of monotherapies based on oral artemisinin from the markets". Artemisia is banned in several European countries.
Recourse to the traditional pharmacopoeia
The announcement of the first cases of people infected with Covid-19 has caused in Madagascar a great revival of interest in a whole series of medicinal plants or products such as ginger and lemon supposed to cure or, at the very least, protect from virus. In Madagascar, Imra has been working for several weeks on a treatment against Covid-19. The researchers therefore relied on the results obtained with the Covid-Organics already used to fight against malaria.
According to President Rajoelina "the patients treated with Covid-Organics have been cured". "Patients in respiratory distress have been out of the woods and have already been discharged from the hospital," he added. According to the latest report, 121 cases of contamination by Covid-19, including 39 now considered cured, have been officially reported on the Big Island. None caused the death of a patient.
The opportunity for the head of state to castigate the mentality of certain people who do not trust their leaders or their researchers. According to the national press, Covid-Organics could propel Madagascar to the forefront of the international medical scene and even shake up the world of finance. Artemisia is produced mainly in Madagascar, Africa and Asia.
The stakes are high for the African continent, which records 92% of the 445,000 annual deaths from the disease each year and 90% of the 219 million cases worldwide. Inexpensive herbal medicine would be an advantage over the often more expensive, rare or fake drugs.
In five years, several Artemisia Houses, an association which promotes the use of artemisia founded by the Frenchwoman Lucile Cornet-Vernet, have been created in nearly 23 countries on the continent: Senegal, C?te d'Ivoire, Congo and many others. For this association, it is enough to take the plant in herbal tea for seven days for it to cure and prevent malaria.
Warnings against artemisia
Historically, the virtues of artemisia were revealed to Westerners during the Vietnam War. Indeed, the Americans who fought in the rice fields were treated with chloroquine, a synthetic drug. For their part, the Vietnamese had nothing but died in droves of malaria. For the record, some veterans have even declared that malaria is more formidable than the G.I's. The North Vietnamese then called the Chinese to the rescue who provided them with Artemisia annua to treat the Vietnamese fighters. However, the scientific community is concerned about the side effects of artemisia and remains skeptical about its effectiveness.
The National Academy of Medicine in France warns. If the molecule of artemisinin contained in one of the varieties of artemisia is effectively used in the majority of the antimalarial drugs, "it is its association with other molecules which is necessary to effectively cure the disease by delaying the appearance of resistances “, Recalls Professor Sandrine Houz?, parasitologist at the Bichat hospital in Paris. Not all artemisia species contain artemisinin, she says. And, unlike the tablets which guarantee a constant dosage, the concentration of artemisinin contained in the plant varies according to its mode of culture.
The Madagascan president has already indicated that his "remedy" would be prescribed in the form of syrup "to all students to enable them to protect themselves against the pandemic". "We will gradually restore the normal course of life of the population and their livelihoods," said President Rajoelina in a televised speech, "we will start by doing it for half a day, in the morning from 6 am to 1 pm hours ”.
From Monday morning, public transport will resume their service in the capital Antananarivo and in Fianarantsoa (center) and Toamasina (east) and the schools will reopen for certain classes on Wednesday, he said. The inhabitants will however not be able to “leave their city” and their deconfinement will pass by the obligatory port on the public highway of masks which will begin to be distributed as of Monday. Those who do not wear it will be punished with community service, threatened the head of state.
Le Point / MCP, mediacongo.net
https://www.mediacongo.net/article-a..._a_valide.html