tetano
Editor, Senior Moderator
J Virol. 2013 Sep 11. [Epub ahead of print]
Differing epidemiological dynamics of influenza B lineages in Guangzhou, southern China, 2009-2010.
Tan Y, Guan W, Tsan-Yuk Lam T, Pan S, Wu S, Zhan Y, Viboud C, Holmes EC, Yang Z.
Source
Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
Abstract
The epidemiological and evolutionary dynamics of the two co-circulating lineages of influenza B virus, Victoria and Yamagata, are poorly understood, especially in tropical or subtropical areas of Southeast Asia. We performed a phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza B viruses isolated in Guangzhou, a southern Chinese city, during 2009-2010, and compared the demographic and clinical features of infected patients. We identified multiple viral introductions of Victoria strains from both Chinese and international sources, which formed two phylogenetically and antigenically distinct clades (Victoria 1 and 2), some of which persisted between seasons. We identified one dominant Yamagata introduction from outside China during 2009. Our phylogenetic analysis reveals the occurrence of reassortment events among the Victoria and Yamagata lineages and also within the Victoria lineage. We found no significant difference in clinical severity by influenza B lineage, with the exceptions that; (i) the Yamagata lineage infected older people than either Victoria lineages, and (ii) fewer upper respiratory tract infections were found in the Victoria 2 than the Victoria 1 clade. Overall, our study reveals the complex epidemiological dynamics of different influenza B lineages within a single geographic locality, and has implications for vaccination policy in southern China.
PMID:
24027322
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24027322
Differing epidemiological dynamics of influenza B lineages in Guangzhou, southern China, 2009-2010.
Tan Y, Guan W, Tsan-Yuk Lam T, Pan S, Wu S, Zhan Y, Viboud C, Holmes EC, Yang Z.
Source
Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
Abstract
The epidemiological and evolutionary dynamics of the two co-circulating lineages of influenza B virus, Victoria and Yamagata, are poorly understood, especially in tropical or subtropical areas of Southeast Asia. We performed a phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza B viruses isolated in Guangzhou, a southern Chinese city, during 2009-2010, and compared the demographic and clinical features of infected patients. We identified multiple viral introductions of Victoria strains from both Chinese and international sources, which formed two phylogenetically and antigenically distinct clades (Victoria 1 and 2), some of which persisted between seasons. We identified one dominant Yamagata introduction from outside China during 2009. Our phylogenetic analysis reveals the occurrence of reassortment events among the Victoria and Yamagata lineages and also within the Victoria lineage. We found no significant difference in clinical severity by influenza B lineage, with the exceptions that; (i) the Yamagata lineage infected older people than either Victoria lineages, and (ii) fewer upper respiratory tract infections were found in the Victoria 2 than the Victoria 1 clade. Overall, our study reveals the complex epidemiological dynamics of different influenza B lineages within a single geographic locality, and has implications for vaccination policy in southern China.
PMID:
24027322
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24027322