tetano
Editor, Senior Moderator
Arch Med Res. 2015 Dec 13. pii: S0188-4409(15)00287-8. doi: 10.1016/j.arcmed.2015.12.003. [Epub ahead of print]
[h=1]Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter.[/h] Arriaga-Pizano L[SUP]1[/SUP], Ferat-Osorio E[SUP]2[/SUP], Rodr?guez-Abrego G[SUP]3[/SUP], Mancilla-Herrera I[SUP]4[/SUP], Dom?nguez-Cerezo E[SUP]5[/SUP], Valero-Pacheco N[SUP]5[/SUP], P?rez-Toledo M[SUP]5[/SUP], Lozano-Pati?o F[SUP]6[/SUP], Laredo-S?nchez F[SUP]6[/SUP], Malag?n-Rangel J[SUP]6[/SUP], Nellen-Hummel H[SUP]6[/SUP], Gonz?lez-Bonilla C[SUP]7[/SUP], Arteaga-Troncoso G[SUP]8[/SUP], C?rbulo-V?zquez A[SUP]9[/SUP], Pastelin-Palacios R[SUP]10[/SUP], Klenerman P[SUP]11[/SUP], Isibasi A[SUP]1[/SUP], L?pez-Mac?as C[SUP]12[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND AND AIMS:[/h] Severe influenza A(H1N1)pdm2009 virus infection cases are characterized by sustained immune activation during influenza pandemics. Seasonal flu data suggest that immune mediators could be modified by wave-related changes. Our aim was to determine the behavior of soluble and cell-related mediators in two waves at the epicenter of the 2009 influenza pandemic.
[h=4]METHODS:[/h] Leukocyte surface activation markers were studied in serum from peripheral blood samples, collected from the 1[SUP]st[/SUP] (April-May, 2009) and 2[SUP]nd[/SUP] (October 2009-February 2010) pandemic waves. Patients with confirmed influenza A(H1N1)pdm2009 virus infection (H1N1), influenza-like illness (ILI) or healthy donors (H) were analyzed.
[h=4]RESULTS:[/h] Serum IL-6, IL-4 and IL-10 levels were elevated in H1N1 patients from the 2[SUP]nd[/SUP] pandemic wave. Additionally, the frequency of helper and cytotoxic T cells was reduced during the 1[SUP]st[/SUP] wave, whereas CD69 expression in helper T cells was increased in the 2[SUP]nd[/SUP] wave for both H1N1 and ILI patients. In contrast, CD62L expression in granulocytes from the ILI group was increased in both waves but in monocytes only in the 2[SUP]nd[/SUP] wave. Triggering Receptor Expressed on Myeloid cells (TREM)-1 expression was elevated only in H1N1 patients at the 1[SUP]st[/SUP] wave.
[h=4]CONCLUSIONS:[/h] Our results show that during the 2009 influenza pandemic a T cell activation phenotype is observed in a wave-dependent fashion, with an expanded activation in the 2[SUP]nd[/SUP] wave, compared to the 1[SUP]st[/SUP] wave. Conversely, granulocyte and monocyte activation is infection-dependent. This evidence collected at the pandemic epicenter in 2009 could help us understand the differences in the underlying cellular mechanisms that drive the wave-related immune profile behaviors that occur against influenza viruses during pandemics.
Copyright ? 2015 IMSS. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Immune profiles; Pandemic A(H1N1)pdm2009 influenza; Pandemic waves
PMID: 26696552 [PubMed - as supplied by publisher]
[h=1]Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter.[/h] Arriaga-Pizano L[SUP]1[/SUP], Ferat-Osorio E[SUP]2[/SUP], Rodr?guez-Abrego G[SUP]3[/SUP], Mancilla-Herrera I[SUP]4[/SUP], Dom?nguez-Cerezo E[SUP]5[/SUP], Valero-Pacheco N[SUP]5[/SUP], P?rez-Toledo M[SUP]5[/SUP], Lozano-Pati?o F[SUP]6[/SUP], Laredo-S?nchez F[SUP]6[/SUP], Malag?n-Rangel J[SUP]6[/SUP], Nellen-Hummel H[SUP]6[/SUP], Gonz?lez-Bonilla C[SUP]7[/SUP], Arteaga-Troncoso G[SUP]8[/SUP], C?rbulo-V?zquez A[SUP]9[/SUP], Pastelin-Palacios R[SUP]10[/SUP], Klenerman P[SUP]11[/SUP], Isibasi A[SUP]1[/SUP], L?pez-Mac?as C[SUP]12[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND AND AIMS:[/h] Severe influenza A(H1N1)pdm2009 virus infection cases are characterized by sustained immune activation during influenza pandemics. Seasonal flu data suggest that immune mediators could be modified by wave-related changes. Our aim was to determine the behavior of soluble and cell-related mediators in two waves at the epicenter of the 2009 influenza pandemic.
[h=4]METHODS:[/h] Leukocyte surface activation markers were studied in serum from peripheral blood samples, collected from the 1[SUP]st[/SUP] (April-May, 2009) and 2[SUP]nd[/SUP] (October 2009-February 2010) pandemic waves. Patients with confirmed influenza A(H1N1)pdm2009 virus infection (H1N1), influenza-like illness (ILI) or healthy donors (H) were analyzed.
[h=4]RESULTS:[/h] Serum IL-6, IL-4 and IL-10 levels were elevated in H1N1 patients from the 2[SUP]nd[/SUP] pandemic wave. Additionally, the frequency of helper and cytotoxic T cells was reduced during the 1[SUP]st[/SUP] wave, whereas CD69 expression in helper T cells was increased in the 2[SUP]nd[/SUP] wave for both H1N1 and ILI patients. In contrast, CD62L expression in granulocytes from the ILI group was increased in both waves but in monocytes only in the 2[SUP]nd[/SUP] wave. Triggering Receptor Expressed on Myeloid cells (TREM)-1 expression was elevated only in H1N1 patients at the 1[SUP]st[/SUP] wave.
[h=4]CONCLUSIONS:[/h] Our results show that during the 2009 influenza pandemic a T cell activation phenotype is observed in a wave-dependent fashion, with an expanded activation in the 2[SUP]nd[/SUP] wave, compared to the 1[SUP]st[/SUP] wave. Conversely, granulocyte and monocyte activation is infection-dependent. This evidence collected at the pandemic epicenter in 2009 could help us understand the differences in the underlying cellular mechanisms that drive the wave-related immune profile behaviors that occur against influenza viruses during pandemics.
Copyright ? 2015 IMSS. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Immune profiles; Pandemic A(H1N1)pdm2009 influenza; Pandemic waves
PMID: 26696552 [PubMed - as supplied by publisher]