tetano
Editor, Senior Moderator
Biomed Res Int. 2019 Oct 22;2019:4794910. doi: 10.1155/2019/4794910. eCollection 2019. [h=1]Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes.[/h]
Wang Y[SUP]1,[/SUP][SUP]2[/SUP], Song T[SUP]1[/SUP], Li K[SUP]1[/SUP], Jin Y[SUP]1[/SUP], Yue J[SUP]1[/SUP], Ren H[SUP]1[/SUP], Liang L[SUP]1[/SUP].
[h=3]Author information[/h] 1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing 100071, China. 2 Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
[h=3]Abstract[/h] Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus. In this paper, we found that the same proteins (nucleoprotein and neuraminidase) of H1N1 and H5N1 have different impacts on the NF-κB activation. By further examining the virus-host protein-protein interactions, we found that both NP and NA proteins of the H1N1 and H5N1 viruses target different host proteins. These results indicate that different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes.
Copyright ? 2019 Yujie Wang et al.
PMID: 31772934 PMCID: PMC6854240 DOI: 10.1155/2019/4794910
Wang Y[SUP]1,[/SUP][SUP]2[/SUP], Song T[SUP]1[/SUP], Li K[SUP]1[/SUP], Jin Y[SUP]1[/SUP], Yue J[SUP]1[/SUP], Ren H[SUP]1[/SUP], Liang L[SUP]1[/SUP].
[h=3]Author information[/h] 1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing 100071, China. 2 Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
[h=3]Abstract[/h] Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus. In this paper, we found that the same proteins (nucleoprotein and neuraminidase) of H1N1 and H5N1 have different impacts on the NF-κB activation. By further examining the virus-host protein-protein interactions, we found that both NP and NA proteins of the H1N1 and H5N1 viruses target different host proteins. These results indicate that different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes.
Copyright ? 2019 Yujie Wang et al.
PMID: 31772934 PMCID: PMC6854240 DOI: 10.1155/2019/4794910