tetano
Editor, Senior Moderator
J Infect Dis. 2014 Feb 4. [Epub ahead of print]
Differences in Antibody Responses between TIV and LAIV Influenza Vaccines Correlate with the Kinetics and Magnitude of Interferon Signaling in Children.
Cao RG, Suarez NM, Obermoser G, Lopez SM, Flano E, Mertz SE, Albrecht RA, Garc?a-Sastre A, Mejias A, Xu H, Qin H, Blankenship D, Palucka K, Pascual V, Ramilo O.
Author information
Abstract
Background. LAIV and TIV influenza vaccines are effective for prevention of influenza infection in children, but the mechanisms associated with protection are not well defined.Methods. We analyzed the differences in B cell responses and transcriptional profiles in children 6 months to 14 years old immunized with these two vaccines.Results. LAIV elicited a significant increase in na?ve, memory and transitional B cells on day 30 post-vaccination, while TIV elicited an increased number of plasmablasts on day 7. Antibody titers against the three vaccine strains (H1N1, H3N2 and B) were significantly higher in the TIV group and correlated with number of antibody-secreting cells. Both vaccines induced over expression of interferon signaling genes, but with different kinetics. TIV induced expression of interferon genes on day 1 in all age groups, and LAIV on day 7 post-vaccination but only in children younger than 5 years old. Interferon-related genes over expressed in both vaccinated groups correlated with H3N2 antibody titers.Conclusions. These results suggest that LAIV and TIV induced significantly different B cell responses in vaccinated children. Early induction of interferon appears important for development of antibody responses.
PMID:
24495909
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24495909
Differences in Antibody Responses between TIV and LAIV Influenza Vaccines Correlate with the Kinetics and Magnitude of Interferon Signaling in Children.
Cao RG, Suarez NM, Obermoser G, Lopez SM, Flano E, Mertz SE, Albrecht RA, Garc?a-Sastre A, Mejias A, Xu H, Qin H, Blankenship D, Palucka K, Pascual V, Ramilo O.
Author information
Abstract
Background. LAIV and TIV influenza vaccines are effective for prevention of influenza infection in children, but the mechanisms associated with protection are not well defined.Methods. We analyzed the differences in B cell responses and transcriptional profiles in children 6 months to 14 years old immunized with these two vaccines.Results. LAIV elicited a significant increase in na?ve, memory and transitional B cells on day 30 post-vaccination, while TIV elicited an increased number of plasmablasts on day 7. Antibody titers against the three vaccine strains (H1N1, H3N2 and B) were significantly higher in the TIV group and correlated with number of antibody-secreting cells. Both vaccines induced over expression of interferon signaling genes, but with different kinetics. TIV induced expression of interferon genes on day 1 in all age groups, and LAIV on day 7 post-vaccination but only in children younger than 5 years old. Interferon-related genes over expressed in both vaccinated groups correlated with H3N2 antibody titers.Conclusions. These results suggest that LAIV and TIV induced significantly different B cell responses in vaccinated children. Early induction of interferon appears important for development of antibody responses.
PMID:
24495909
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24495909