tetano
Editor, Senior Moderator
Diagnosis (Berl)
. 2022 Jun 16.
doi: 10.1515/dx-2022-0042. Online ahead of print.
Homocysteine in coronavirus disease (COVID-19): a systematic literature review
Giovanni Carpenè[SUP] 1 [/SUP], Davide Negrini[SUP] 1 [/SUP], Brandon M Henry[SUP] 2 [/SUP], Martina Montagnana[SUP] 1 [/SUP], Giuseppe Lippi[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: Coronavirus disease 2019 (COVID-19) is a life-threatening infectious disorder characterized by a sustained prothrombotic state. Since homocysteine is a potential biomarker of thrombotic diseases, the aim of this article is to provide an updated overview on the possible role played by hyperhomocysteinemia in influencing an unfavorable COVID-19 progression.
Methods: We carried out an electronic search in Medline (PubMed interface) using the keywords ("COVID-19" OR "SARS-CoV-2") AND "homocysteine", between 2019 and the present time, with no language restrictions, to identify all articles which explored the concentration of homocysteine in COVID-19 patients with or without unfavorable disease progression.
Results: Three studies, totaling 694 hospitalized COVID-19 patients, were included in our systematic review. Overall, the differences between the mean homocysteine values in non-severe vs. severe COVID-19 patients were always positive (i.e., 15.1%, 24.1% and 22.8%, generating a positive weight mean difference of 1.75 μmol/L (95%CI, 1.26-2.25 μmol/L; p=0.011), which translates into a cumulative difference of approximately ∼1.2 μmol/L.
Conclusions: Despite the limited evidence that has been garnered so far, increased homocysteine levels may be a potentially useful marker for predicting the risk of unfavorable progression in patients with COVID-19.
Keywords: COVID-19; SARS-CoV-2; homocysteine; systematic literature review.
. 2022 Jun 16.
doi: 10.1515/dx-2022-0042. Online ahead of print.
Homocysteine in coronavirus disease (COVID-19): a systematic literature review
Giovanni Carpenè[SUP] 1 [/SUP], Davide Negrini[SUP] 1 [/SUP], Brandon M Henry[SUP] 2 [/SUP], Martina Montagnana[SUP] 1 [/SUP], Giuseppe Lippi[SUP] 1 [/SUP]
Affiliations
- PMID: 35704707
- DOI: 10.1515/dx-2022-0042
Abstract
Objectives: Coronavirus disease 2019 (COVID-19) is a life-threatening infectious disorder characterized by a sustained prothrombotic state. Since homocysteine is a potential biomarker of thrombotic diseases, the aim of this article is to provide an updated overview on the possible role played by hyperhomocysteinemia in influencing an unfavorable COVID-19 progression.
Methods: We carried out an electronic search in Medline (PubMed interface) using the keywords ("COVID-19" OR "SARS-CoV-2") AND "homocysteine", between 2019 and the present time, with no language restrictions, to identify all articles which explored the concentration of homocysteine in COVID-19 patients with or without unfavorable disease progression.
Results: Three studies, totaling 694 hospitalized COVID-19 patients, were included in our systematic review. Overall, the differences between the mean homocysteine values in non-severe vs. severe COVID-19 patients were always positive (i.e., 15.1%, 24.1% and 22.8%, generating a positive weight mean difference of 1.75 μmol/L (95%CI, 1.26-2.25 μmol/L; p=0.011), which translates into a cumulative difference of approximately ∼1.2 μmol/L.
Conclusions: Despite the limited evidence that has been garnered so far, increased homocysteine levels may be a potentially useful marker for predicting the risk of unfavorable progression in patients with COVID-19.
Keywords: COVID-19; SARS-CoV-2; homocysteine; systematic literature review.