tetano
Editor, Senior Moderator
Diagn Microbiol Infect Dis
. 2024 Apr 4;109(3):116284.
doi: 10.1016/j.diagmicrobio.2024.116284. Online ahead of print. Increased Rheumatoid Factor production in patients with severe COVID-19
Mourad Elghali[SUP] 1 [/SUP], I Bannour[SUP] 1 [/SUP], I Touil[SUP] 2 [/SUP], M Changuel[SUP] 1 [/SUP], Y Brahem[SUP] 2 [/SUP], O Jaoued[SUP] 3 [/SUP], N Boudawara[SUP] 2 [/SUP], H Ibn Hadj Amor[SUP] 4 [/SUP], S Elatrous[SUP] 3 [/SUP], J Knani[SUP] 2 [/SUP], N Sakly[SUP] 5 [/SUP]
Affiliations
Background: Searching for Rheumatoid Factors (RF) in patients with coronavirus disease (COVID-19) has rarely been described.
Objectives: To investigate the association between RF isotypes (IgM, IgA, and IgG) and different clinical presentations of COVID-19 in a series of Tunisian patients.
Study design: Eighty-two COVID-19 patients were enrolled in this study. Symptomatic cases were recruited from the Department of COVID-19 and the intensive care unit (ICU) of the University Hospital of Mahdia, Tunisia, from January 2021 to March 2021. Different RF isotypes were assessed using a commercial enzyme-linked immunosorbent assay (ELISA).
Results: Forty-one patients (50%) had RF of any isotype. Thirty-two patients (39%) were tested positive for RF-IgM. Symptomatic forms of the disease were associated with RF-IgM positivity (p = 0.005). The mean concentration of RF-IgM was higher in the severe form than in the moderate and asymptomatic forms (p = 0.006).
Conclusions: Our study suggests that the production of RF-IgM isotype is increased in patients with severe COVID-19.
Keywords: Covid-19; Infection; Rheumatoid factor; Viruses.
. 2024 Apr 4;109(3):116284.
doi: 10.1016/j.diagmicrobio.2024.116284. Online ahead of print. Increased Rheumatoid Factor production in patients with severe COVID-19
Mourad Elghali[SUP] 1 [/SUP], I Bannour[SUP] 1 [/SUP], I Touil[SUP] 2 [/SUP], M Changuel[SUP] 1 [/SUP], Y Brahem[SUP] 2 [/SUP], O Jaoued[SUP] 3 [/SUP], N Boudawara[SUP] 2 [/SUP], H Ibn Hadj Amor[SUP] 4 [/SUP], S Elatrous[SUP] 3 [/SUP], J Knani[SUP] 2 [/SUP], N Sakly[SUP] 5 [/SUP]
Affiliations
- PMID: 38604077
- DOI: 10.1016/j.diagmicrobio.2024.116284
Background: Searching for Rheumatoid Factors (RF) in patients with coronavirus disease (COVID-19) has rarely been described.
Objectives: To investigate the association between RF isotypes (IgM, IgA, and IgG) and different clinical presentations of COVID-19 in a series of Tunisian patients.
Study design: Eighty-two COVID-19 patients were enrolled in this study. Symptomatic cases were recruited from the Department of COVID-19 and the intensive care unit (ICU) of the University Hospital of Mahdia, Tunisia, from January 2021 to March 2021. Different RF isotypes were assessed using a commercial enzyme-linked immunosorbent assay (ELISA).
Results: Forty-one patients (50%) had RF of any isotype. Thirty-two patients (39%) were tested positive for RF-IgM. Symptomatic forms of the disease were associated with RF-IgM positivity (p = 0.005). The mean concentration of RF-IgM was higher in the severe form than in the moderate and asymptomatic forms (p = 0.006).
Conclusions: Our study suggests that the production of RF-IgM isotype is increased in patients with severe COVID-19.
Keywords: Covid-19; Infection; Rheumatoid factor; Viruses.