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Diagn Microbiol Infect Dis . Frequency of respiratory pathogens other than SARS-CoV-2 detected during COVID-19 testing

tetano

Editor, Senior Moderator
Diagn Microbiol Infect Dis


. 2021 Oct 22;102(2):115576.
doi: 10.1016/j.diagmicrobio.2021.115576. Online ahead of print.
Frequency of respiratory pathogens other than SARS-CoV-2 detected during COVID-19 testing


Matheus Negri Boschiero[SUP] 1 [/SUP], Aires Duarte[SUP] 2 [/SUP], Camila Vantini Capasso Palamim[SUP] 1 [/SUP], Alfonso Eduardo Alvarez[SUP] 3 [/SUP], Renan Marrichi Mauch[SUP] 4 [/SUP], Fernando Augusto Lima Marson[SUP] 5 [/SUP]



Affiliations

Abstract

The frequencies of 19 respiratory pathogens other than SARS-CoV-2 were assessed in 6,"?>235 Brazilian individuals tested for COVID-19. Overall, only 83 individuals who tested positive for SARS-CoV-2 had codetection of other pathogens. Individuals infected with Rhinovirus/Enterovirus, Human Coronavirus (HCoV)-HKU1, HCoV-NL63, HPIV-4, Influenza A (-H1N1 and other subtypes), Influenza B, Human Respiratory Syncytial Virus and Human Metapneumovirus were less likely to test positive for SARS-CoV-2. Infection with Streptococcys pyogenes, Chlamydophila pneumoniae, Mycoplasma pneumoniae, and Bordetella pertussis were more frequent in individuals who tested negative for SARS-CoV-2, but without significancy. We found 150 individuals infected with ≥2 pathogens other than SARS-CoV-2, only 3 out of whom tested positive for COVID-19. The codetection frequency was low in individuals diagnosed with COVID-19. Other viral infections may provide a cross-reactive, protective immune response against SARS-CoV-2. Screening for bacterial respiratory infections upon COVID-19 testing is important to drive suitable therapeutic approaches and avoid unnecessary antibiotic prescription.

Keywords: COVID-19; Codetection; Pandemic; SARS-CoV-2.
 
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