Diagn Microbiol Infect Dis . Evaluation of the cobas Liat detection test for SARS-CoV-2 and influenza viruses following the emergence of the SARS-C

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Diagn Microbiol Infect Dis


. 2023 Jan 4;105(4):115891.
doi: 10.1016/j.diagmicrobio.2023.115891. Online ahead of print.
Evaluation of the cobas Liat detection test for SARS-CoV-2 and influenza viruses following the emergence of the SARS-CoV-2 Omicron variant


Kuenyoul Park[SUP] 1 [/SUP], Heungsup Sung[SUP] 2 [/SUP], Mi-Na Kim[SUP] 3 [/SUP]



Affiliations

• PMID: 36738537
• DOI: 10.1016/j.diagmicrobio.2023.115891

Abstract

Objectives: This study assessed the clinical performance of the cobas Liat SARS‑CoV‑2 & Influenza A/B assay (LiatCOVID/flu) for the detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses during the SARS-CoV-2 Omicron outbreak.
Methods: Residual nasopharyngeal swab samples (NPS) previously tested with cobas SARS-CoV-2 & Influenza A/B for SARS-CoV-2 and with the Allplex Respiratory Panel 1 for influenza viruses were collected. All samples were submitted to the LiatCOVID/flu assay.
Results: A total of 1147 samples were collected comprising 167 SARS-CoV-2-positive, 556 SARS-CoV-2-negative, 224 influenza-positive, and 200 influenza-negative cases. The positive percent agreement (PPA)/negative percent agreement (NPA) of LiatCOVID/flu for SARS-CoV-2 and influenza viruses compared to the previously tested methods were 100% of 100% and 99.6% of 100%, respectively.
Conclusions: The LiatCOVID/flu assay shows an acceptable performance in the detection of SARS-CoV-2 and influenza viruses using NPS samples.

Keywords: COVID-19; POCT; SARS-CoV-2; influenza; nasopharyngeal swab; rapid diagnostic test.