tetano
Editor, Senior Moderator
Diabetes Metab Syndr
. 2020 Aug 26;14(6):1613-1615.
doi: 10.1016/j.dsx.2020.08.023. Online ahead of print.
Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection
Timotius Ivan Hariyanto[SUP] 1 [/SUP], Andree Kurniawan[SUP] 2 [/SUP]
Affiliations
Abstract
Background and aims: The coronavirus disease 2019 (COVID-19) number of death cases is still increasing. One of the comorbidities associated with severe outcome and mortality of COVID-19 is dyslipidemia. Statin is one of the drugs which is most commonly used for the treatment of dyslipidemic patients. This study aims to analyze the association between statin use and in-hospital outcomes of COVID-19 infection.
Methods: We systematically searched the Google Scholar database using specific keywords related to our aims until August 1st, 2020. All articles published on COVID-19 and statin were retrieved. Statistical analysis was done using Review Manager 5.4 software.
Results: A total of 9 studies with a total of 3449 patients were included in our analysis. Our meta-analysis showed that statin use did not improve severity outcome [OR 1.64 (95% CI 0.51-5.23), p = 0.41, I[SUP]2[/SUP] = 93%, random-effect modelling] nor mortality rate from COVID-19 infection [OR 0.78 (95% CI 0.50-1.21), p = 0.26, I[SUP]2[/SUP] = 0%, fixed-effect modelling].
Conclusion: Statin use did not improve in-hospital outcomes of COVID-19 infections. Patients with dyslipidemia should continue taking statin drugs despite COVID-19 infection status, given its beneficial effects on cardiovascular outcomes.
Keywords: COVID-19; Coronavirus disease 2019; Dyslipidemia; Statin; Treatment.
. 2020 Aug 26;14(6):1613-1615.
doi: 10.1016/j.dsx.2020.08.023. Online ahead of print.
Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection
Timotius Ivan Hariyanto[SUP] 1 [/SUP], Andree Kurniawan[SUP] 2 [/SUP]
Affiliations
- PMID: 32882643
- DOI: 10.1016/j.dsx.2020.08.023
Abstract
Background and aims: The coronavirus disease 2019 (COVID-19) number of death cases is still increasing. One of the comorbidities associated with severe outcome and mortality of COVID-19 is dyslipidemia. Statin is one of the drugs which is most commonly used for the treatment of dyslipidemic patients. This study aims to analyze the association between statin use and in-hospital outcomes of COVID-19 infection.
Methods: We systematically searched the Google Scholar database using specific keywords related to our aims until August 1st, 2020. All articles published on COVID-19 and statin were retrieved. Statistical analysis was done using Review Manager 5.4 software.
Results: A total of 9 studies with a total of 3449 patients were included in our analysis. Our meta-analysis showed that statin use did not improve severity outcome [OR 1.64 (95% CI 0.51-5.23), p = 0.41, I[SUP]2[/SUP] = 93%, random-effect modelling] nor mortality rate from COVID-19 infection [OR 0.78 (95% CI 0.50-1.21), p = 0.26, I[SUP]2[/SUP] = 0%, fixed-effect modelling].
Conclusion: Statin use did not improve in-hospital outcomes of COVID-19 infections. Patients with dyslipidemia should continue taking statin drugs despite COVID-19 infection status, given its beneficial effects on cardiovascular outcomes.
Keywords: COVID-19; Coronavirus disease 2019; Dyslipidemia; Statin; Treatment.