tetano
Editor, Senior Moderator
Diabetes Metab Syndr
. 2020 May 12;14(4):655-659.
doi: 10.1016/j.dsx.2020.05.020. Online ahead of print.
Obesity as a Predictor for a Poor Prognosis of COVID-19: A Systematic Review
Alice Tamara[SUP] 1 [/SUP], Dicky L Tahapary[SUP] 2 [/SUP]
Affiliations
Abstract
Background and aims: COVID-19 is an emerging pandemic due to droplet infection of 2019-novel coronavirus (2019-nCoV). Due to its rapid transmission and high case-fatality rate, recognition of its risk and prognostic factor is important. Obesity has been associated with impaired immune system, increasing the susceptibility for 2019-nCoV infection. We aimed to study the impact of obesity to the prognosis and disease severity of COVID-19.
Methods: A systematic search and handsearching was conducted in four databases: Cochrane, MEDLINE, EMBASE, and PubMed. The identified articles were screened using the chosen eligibility criteria. We obtained three retrospective cohort studies (Wu J et al., Lighter J et al., and Simonnet A et al.) to be critically appraised using Newcastle Ottawa Scale.
Results: The findings of all included studies were consistent in stating the contribution of obesity as a risk factor to increase the requirement for advanced medical care. Study with the highest quality, Simonnet A et al., reported an increase need of invasive mechanical ventilation in COVID-19 patients with body mass index higher than 35 kg/m[SUP]2[/SUP], OR: 7.36 (1.63-33.14; p = 0.021). This is associated with a higher mortality rate in obese population infected with COVID-19.
Conclusion: Obesity is an independent risk and prognostic factor for the disease severity and the requirement of advanced medical care in COVID-19. This systematic review highlights a particularly vulnerable group - obese, and emphasises on the importance of treatment aggression and disease prevention in this population group.
Keywords: COVID-19; Obesity; Predictor; Prognosis.
. 2020 May 12;14(4):655-659.
doi: 10.1016/j.dsx.2020.05.020. Online ahead of print.
Obesity as a Predictor for a Poor Prognosis of COVID-19: A Systematic Review
Alice Tamara[SUP] 1 [/SUP], Dicky L Tahapary[SUP] 2 [/SUP]
Affiliations
- PMID: 32438328
- DOI: 10.1016/j.dsx.2020.05.020
Abstract
Background and aims: COVID-19 is an emerging pandemic due to droplet infection of 2019-novel coronavirus (2019-nCoV). Due to its rapid transmission and high case-fatality rate, recognition of its risk and prognostic factor is important. Obesity has been associated with impaired immune system, increasing the susceptibility for 2019-nCoV infection. We aimed to study the impact of obesity to the prognosis and disease severity of COVID-19.
Methods: A systematic search and handsearching was conducted in four databases: Cochrane, MEDLINE, EMBASE, and PubMed. The identified articles were screened using the chosen eligibility criteria. We obtained three retrospective cohort studies (Wu J et al., Lighter J et al., and Simonnet A et al.) to be critically appraised using Newcastle Ottawa Scale.
Results: The findings of all included studies were consistent in stating the contribution of obesity as a risk factor to increase the requirement for advanced medical care. Study with the highest quality, Simonnet A et al., reported an increase need of invasive mechanical ventilation in COVID-19 patients with body mass index higher than 35 kg/m[SUP]2[/SUP], OR: 7.36 (1.63-33.14; p = 0.021). This is associated with a higher mortality rate in obese population infected with COVID-19.
Conclusion: Obesity is an independent risk and prognostic factor for the disease severity and the requirement of advanced medical care in COVID-19. This systematic review highlights a particularly vulnerable group - obese, and emphasises on the importance of treatment aggression and disease prevention in this population group.
Keywords: COVID-19; Obesity; Predictor; Prognosis.