tetano
Editor, Senior Moderator
Diabetes Metab Syndr. 2020 May 5;14(4):509-512. doi: 10.1016/j.dsx.2020.04.040. [Epub ahead of print]
Interactions between antihyperglycemic drugs and the renin-angiotensin system: Putative roles in COVID-19. A mini-review.
Nakhleh A[SUP]1[/SUP], Shehadeh N[SUP]2[/SUP].
Author information
Abstract
BACKGROUND:
Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme II (ACE2) receptor for host cell entry. We aimed to assess the interactions between antihyperglycemic drugs and the renin-angiotensin system (RAS) and their putative roles in COVID-19.
METHODS:
A literature search was performed using Pubmed to review the interrelationships between hyperglycemia, RAS and COVID-19, and the effects of antihyperglycemic medications.
RESULTS:
The RAS has an essential role in glucose homeostasis and may have a role in COVID-19-induced lung injury. Some antihyperglycemic medications modulate RAS and might hypothetically alleviate the deleterious effect of angiotensin II on lung injury. Furthermore, most antihyperglycemic medications showed anti-inflammatory effects in animal models of lung injury.
CONCLUSIONS:
Some antihyperglycemic medications might have protective effects against COVID-19-induced lung injury. Early insulin therapy seems very promising in alleviating lung injury.
Copyright ? 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
ACE2; COVID-19; Diabetes mellitus; Glucose-lowering medications; Insulin therapy
PMID:32388330DOI:10.1016/j.dsx.2020.04.040
Interactions between antihyperglycemic drugs and the renin-angiotensin system: Putative roles in COVID-19. A mini-review.
Nakhleh A[SUP]1[/SUP], Shehadeh N[SUP]2[/SUP].
Author information
Abstract
BACKGROUND:
Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme II (ACE2) receptor for host cell entry. We aimed to assess the interactions between antihyperglycemic drugs and the renin-angiotensin system (RAS) and their putative roles in COVID-19.
METHODS:
A literature search was performed using Pubmed to review the interrelationships between hyperglycemia, RAS and COVID-19, and the effects of antihyperglycemic medications.
RESULTS:
The RAS has an essential role in glucose homeostasis and may have a role in COVID-19-induced lung injury. Some antihyperglycemic medications modulate RAS and might hypothetically alleviate the deleterious effect of angiotensin II on lung injury. Furthermore, most antihyperglycemic medications showed anti-inflammatory effects in animal models of lung injury.
CONCLUSIONS:
Some antihyperglycemic medications might have protective effects against COVID-19-induced lung injury. Early insulin therapy seems very promising in alleviating lung injury.
Copyright ? 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
ACE2; COVID-19; Diabetes mellitus; Glucose-lowering medications; Insulin therapy
PMID:32388330DOI:10.1016/j.dsx.2020.04.040