tetano
Editor, Senior Moderator
Diabetes Metab Syndr
. 2020 Dec 30;15(1):229-235.
doi: 10.1016/j.dsx.2020.12.037. Online ahead of print.
Clinical characteristics and outcomes of COVID-19 infected diabetic patients admitted in ICUs of the southern region of Bangladesh
Ayan Saha[SUP] 1 [/SUP], Mohammed Moinul Ahsan[SUP] 2 [/SUP], Md Tarek-Ul Quader[SUP] 3 [/SUP], Sabekun Naher[SUP] 4 [/SUP], Farhana Akter[SUP] 5 [/SUP], H M Hamidullah Mehedi[SUP] 6 [/SUP], Asm Arman Ullah Chowdhury[SUP] 2 [/SUP], Md Hasanul Karim[SUP] 2 [/SUP], Tazrina Rahman[SUP] 7 [/SUP], Ayesha Parvin[SUP] 8 [/SUP]
Affiliations
Abstract
Background and aims: Diabetes mellitus is highly prevalent among critical cases of coronavirus disease 2019 (COVID-19) with poor outcomes. This study aimed to describe the clinical characteristics and outcomes of COVID-19 patients with diabetes, admitted in the intensive care unit (ICU) of the southern region of Bangladesh.
Methods: Epidemiological, clinical, laboratory, treatments, complications, and clinical outcomes data were extracted from electronic medical records of 168 COVID-19 patients admitted into ICU of two COVID-19 dedicated hospitals of Chattogram, Bangladesh and compared between diabetes (n = 88) and non-diabetes (n = 80) groups.
Results: The prevalence of diabetes was high among 51-70 years old patients. All the diabetic patients had at least one other comorbidity, with a significantly higher incidence of hypertension (53.4% vs 27.5%, P < 0.05). Prevalence of male patients (74/88; 84.1%) was slightly higher among diabetic patients than the non-diabetic patients (60/80; 75%). Even though not significant, Kaplan-Meier survival curve showed that COVID-19 patients with diabetes had a shorter overall survival time than those without diabetes. In subgroup analysis, diabetic patients were classified into insulin-requiring and non-insulin-requiring groups based on their requirement of insulin during the stay in ICU. COVID-19 infected diabetic patients requiring insulin have high risk of disease progression and shorter survival time than the non-insulin required group.
Conclusions: Diabetes is an independent risk factor for the poor prognosis of COVID-19. More attention should be paid to the prevention and prompt treatment of diabetic patients, to maintain good glycaemic control especially those who require insulin therapy.
Keywords: Bangladesh; COVID-19; Clinical characteristics; Diabetes mellitus; Epidemiology.
. 2020 Dec 30;15(1):229-235.
doi: 10.1016/j.dsx.2020.12.037. Online ahead of print.
Clinical characteristics and outcomes of COVID-19 infected diabetic patients admitted in ICUs of the southern region of Bangladesh
Ayan Saha[SUP] 1 [/SUP], Mohammed Moinul Ahsan[SUP] 2 [/SUP], Md Tarek-Ul Quader[SUP] 3 [/SUP], Sabekun Naher[SUP] 4 [/SUP], Farhana Akter[SUP] 5 [/SUP], H M Hamidullah Mehedi[SUP] 6 [/SUP], Asm Arman Ullah Chowdhury[SUP] 2 [/SUP], Md Hasanul Karim[SUP] 2 [/SUP], Tazrina Rahman[SUP] 7 [/SUP], Ayesha Parvin[SUP] 8 [/SUP]
Affiliations
- PMID: 33445071
- DOI: 10.1016/j.dsx.2020.12.037
Abstract
Background and aims: Diabetes mellitus is highly prevalent among critical cases of coronavirus disease 2019 (COVID-19) with poor outcomes. This study aimed to describe the clinical characteristics and outcomes of COVID-19 patients with diabetes, admitted in the intensive care unit (ICU) of the southern region of Bangladesh.
Methods: Epidemiological, clinical, laboratory, treatments, complications, and clinical outcomes data were extracted from electronic medical records of 168 COVID-19 patients admitted into ICU of two COVID-19 dedicated hospitals of Chattogram, Bangladesh and compared between diabetes (n = 88) and non-diabetes (n = 80) groups.
Results: The prevalence of diabetes was high among 51-70 years old patients. All the diabetic patients had at least one other comorbidity, with a significantly higher incidence of hypertension (53.4% vs 27.5%, P < 0.05). Prevalence of male patients (74/88; 84.1%) was slightly higher among diabetic patients than the non-diabetic patients (60/80; 75%). Even though not significant, Kaplan-Meier survival curve showed that COVID-19 patients with diabetes had a shorter overall survival time than those without diabetes. In subgroup analysis, diabetic patients were classified into insulin-requiring and non-insulin-requiring groups based on their requirement of insulin during the stay in ICU. COVID-19 infected diabetic patients requiring insulin have high risk of disease progression and shorter survival time than the non-insulin required group.
Conclusions: Diabetes is an independent risk factor for the poor prognosis of COVID-19. More attention should be paid to the prevention and prompt treatment of diabetic patients, to maintain good glycaemic control especially those who require insulin therapy.
Keywords: Bangladesh; COVID-19; Clinical characteristics; Diabetes mellitus; Epidemiology.