tetano
Editor, Senior Moderator
Diabetes Care
. 2020 Aug 25;dc201714.
doi: 10.2337/dc20-1714. Online ahead of print.
Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans
John Xie[SUP] 1 [/SUP], Yuanhao Zu[SUP] 2 [/SUP], Ala Alkhatib[SUP] 1 [/SUP], Thaidan T Pham[SUP] 3 [/SUP], Frances Gill[SUP] 3 [/SUP], Albert Jang[SUP] 4 [/SUP], Stella Radosta[SUP] 4 [/SUP], Gerard Chaaya[SUP] 5 [/SUP], Leann Myers[SUP] 2 [/SUP], Jerry S Zifodya[SUP] 1 [/SUP], Christine M Bojanowski[SUP] 1 [/SUP], Nassir F Marrouche[SUP] 6 [/SUP], Franck Mauvais-Jarvis[SUP] 7 8 [/SUP], Joshua L Denson[SUP] 9 [/SUP]
Affiliations
Abstract
Objective: Coronavirus disease 2019 (COVID-19) mortality is high in patients with hypertension, obesity, and diabetes. We examined the association between hypertension, obesity, and diabetes, individually and clustered as metabolic syndrome (MetS), and COVID-19 outcomes in patients hospitalized in New Orleans during the peak of the outbreak.
Research design and methods: Data were collected from 287 consecutive patients with COVID-19 hospitalized at two hospitals in New Orleans, LA from 30 March to 5 April 2020. MetS was identified per World Health Organization criteria.
Results: Among 287 patients (mean age 61.5 years; female, 56.8%; non-Hispanic black, 85.4%), MetS was present in 188 (66%). MetS was significantly associated with mortality (adjusted odds ratio [aOR] 3.42 [95% CI 1.52-7.69]), intensive care unit (ICU) (aOR 4.59 [CI 2.53-8.32]), invasive mechanical ventilation (IMV) (aOR 4.71 [CI 2.50-8.87]), and acute respiratory distress syndrome (ARDS) (aOR 4.70 [CI 2.25-9.82]) compared with non-MetS. Multivariable analyses of hypertension, obesity, and diabetes individually showed no association with mortality. Obesity was associated with ICU (aOR 2.18 [CI, 1.25-3.81]), ARDS (aOR 2.44 [CI 1.28-4.65]), and IMV (aOR 2.36 [CI 1.33-4.21]). Diabetes was associated with ICU (aOR 2.22 [CI 1.24-3.98]) and IMV (aOR 2.12 [CI 1.16-3.89]). Hypertension was not significantly associated with any outcome. Inflammatory biomarkers associated with MetS, CRP, and lactate dehydrogenase (LDH) were associated with mortality (CRP [aOR 3.66] [CI 1.22-10.97] and LDH [aOR 3.49] [CI 1.78-6.83]).
Conclusions: In predominantly black patients hospitalized for COVID-19, the clustering of hypertension, obesity, and diabetes as MetS increased the odds of mortality compared with these comorbidities individually.
. 2020 Aug 25;dc201714.
doi: 10.2337/dc20-1714. Online ahead of print.
Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans
John Xie[SUP] 1 [/SUP], Yuanhao Zu[SUP] 2 [/SUP], Ala Alkhatib[SUP] 1 [/SUP], Thaidan T Pham[SUP] 3 [/SUP], Frances Gill[SUP] 3 [/SUP], Albert Jang[SUP] 4 [/SUP], Stella Radosta[SUP] 4 [/SUP], Gerard Chaaya[SUP] 5 [/SUP], Leann Myers[SUP] 2 [/SUP], Jerry S Zifodya[SUP] 1 [/SUP], Christine M Bojanowski[SUP] 1 [/SUP], Nassir F Marrouche[SUP] 6 [/SUP], Franck Mauvais-Jarvis[SUP] 7 8 [/SUP], Joshua L Denson[SUP] 9 [/SUP]
Affiliations
- PMID: 32843337
- DOI: 10.2337/dc20-1714
Abstract
Objective: Coronavirus disease 2019 (COVID-19) mortality is high in patients with hypertension, obesity, and diabetes. We examined the association between hypertension, obesity, and diabetes, individually and clustered as metabolic syndrome (MetS), and COVID-19 outcomes in patients hospitalized in New Orleans during the peak of the outbreak.
Research design and methods: Data were collected from 287 consecutive patients with COVID-19 hospitalized at two hospitals in New Orleans, LA from 30 March to 5 April 2020. MetS was identified per World Health Organization criteria.
Results: Among 287 patients (mean age 61.5 years; female, 56.8%; non-Hispanic black, 85.4%), MetS was present in 188 (66%). MetS was significantly associated with mortality (adjusted odds ratio [aOR] 3.42 [95% CI 1.52-7.69]), intensive care unit (ICU) (aOR 4.59 [CI 2.53-8.32]), invasive mechanical ventilation (IMV) (aOR 4.71 [CI 2.50-8.87]), and acute respiratory distress syndrome (ARDS) (aOR 4.70 [CI 2.25-9.82]) compared with non-MetS. Multivariable analyses of hypertension, obesity, and diabetes individually showed no association with mortality. Obesity was associated with ICU (aOR 2.18 [CI, 1.25-3.81]), ARDS (aOR 2.44 [CI 1.28-4.65]), and IMV (aOR 2.36 [CI 1.33-4.21]). Diabetes was associated with ICU (aOR 2.22 [CI 1.24-3.98]) and IMV (aOR 2.12 [CI 1.16-3.89]). Hypertension was not significantly associated with any outcome. Inflammatory biomarkers associated with MetS, CRP, and lactate dehydrogenase (LDH) were associated with mortality (CRP [aOR 3.66] [CI 1.22-10.97] and LDH [aOR 3.49] [CI 1.78-6.83]).
Conclusions: In predominantly black patients hospitalized for COVID-19, the clustering of hypertension, obesity, and diabetes as MetS increased the odds of mortality compared with these comorbidities individually.