tetano
Editor, Senior Moderator
Bioengineered. 2013 Jan 21;4(6). [Epub ahead of print]
Development of a universal CTL-based vaccine for influenza.
Cargnelutti DE, S?nchez MV, Mattion NM, Scodeller EA.
Source
Institute of Experimental Medicine and Biology of Cuyo (IMBECU- CONICET); Mendoza, Argentina.
Abstract
In pursuit of better influenza vaccines, many strategies are being studied worldwide. An attractive alternative is the generation of a broadly cross-reactive vaccine based on the induction of cytotoxic T-lymphocytes (CTL) directed against conserved internal antigens of influenza A virus. The feasibility of this approach using recombinant viral vectors has recently been demonstrated in mice and humans by several research groups. However, similar results might also be achieved through immunization with viral proteins expressed in a prokaryotic system formulated with the appropriate adjuvants and delivery systems. This approach would be much simpler and less expensive. Recent results from several laboratories seem to confirm this is as a valid option to be considered.
PMID:
23337287
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23337287
Development of a universal CTL-based vaccine for influenza.
Cargnelutti DE, S?nchez MV, Mattion NM, Scodeller EA.
Source
Institute of Experimental Medicine and Biology of Cuyo (IMBECU- CONICET); Mendoza, Argentina.
Abstract
In pursuit of better influenza vaccines, many strategies are being studied worldwide. An attractive alternative is the generation of a broadly cross-reactive vaccine based on the induction of cytotoxic T-lymphocytes (CTL) directed against conserved internal antigens of influenza A virus. The feasibility of this approach using recombinant viral vectors has recently been demonstrated in mice and humans by several research groups. However, similar results might also be achieved through immunization with viral proteins expressed in a prokaryotic system formulated with the appropriate adjuvants and delivery systems. This approach would be much simpler and less expensive. Recent results from several laboratories seem to confirm this is as a valid option to be considered.
PMID:
23337287
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23337287