tetano
Editor, Senior Moderator
J Infect Dis. 2020 Feb 8. pii: jiaa061. doi: 10.1093/infdis/jiaa061. [Epub ahead of print] [h=1]Detection of variants with reduced baloxavir marboxil susceptibility after treatment of children with influenza A during the 2018/2019 influenza season.[/h]
Sato M[SUP]1[/SUP], Takashita E[SUP]2[/SUP], Katayose M[SUP]3[/SUP], Nemoto K[SUP]4[/SUP], Sakai N[SUP]5[/SUP], Hashimoto K[SUP]1[/SUP], Hosoya M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During the 2018-2019 influenza seasons, we detected reduced baloxavir marboxil (baloxavir) susceptible variants with I38S or I38T amino acid substitutions on the PA subunit of influenza virus RNA polymerase in 7 of 18 baloxavir treated children and found that virus titer rebounded in some of these children with variants. We also found fever durations to be similar between patients with or without the variants, but the patients with variants shed the virus 3 days longer and took longer to improve clinical symptoms than those without variants. The emergence of these variants should be monitored during future influenza seasons.
? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] antiviral therapy; baloxavir; influenza; oseltamivir; resistance
PMID: 32034420 DOI: 10.1093/infdis/jiaa061
Sato M[SUP]1[/SUP], Takashita E[SUP]2[/SUP], Katayose M[SUP]3[/SUP], Nemoto K[SUP]4[/SUP], Sakai N[SUP]5[/SUP], Hashimoto K[SUP]1[/SUP], Hosoya M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During the 2018-2019 influenza seasons, we detected reduced baloxavir marboxil (baloxavir) susceptible variants with I38S or I38T amino acid substitutions on the PA subunit of influenza virus RNA polymerase in 7 of 18 baloxavir treated children and found that virus titer rebounded in some of these children with variants. We also found fever durations to be similar between patients with or without the variants, but the patients with variants shed the virus 3 days longer and took longer to improve clinical symptoms than those without variants. The emergence of these variants should be monitored during future influenza seasons.
? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] antiviral therapy; baloxavir; influenza; oseltamivir; resistance
PMID: 32034420 DOI: 10.1093/infdis/jiaa061