tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2011 Nov 24. doi: 10.1111/j.1750-2659.2011.00313.x. [Epub ahead of print]
Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests.
Gao F, Loring C, Laviolette M, Bolton D, Daly ER, Bean C.
Source
Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, NH, USA.
Abstract
Please cite this paper as: Gao et al. (2011) Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00313.x. Background The performance of rapid influenza diagnostic tests (RIDTs) in detecting influenza A(H1N1) 2009 has varied widely. Evaluations of RIDTs among infected individuals across all age groups have not been described in depth. Objectives Determine RIDT clinical sensitivity in comparison with influenza detection using real-time RT-PCR among patients infected with influenza A(H1N1) 2009 across all age groups. Study design This study analyzed respiratory specimens received by the New Hampshire Public Health Laboratories (NHPHL) from September 1, 2009, through December 31, 2009. RIDT performance was evaluated among different age groups of patients determined to be infected with influenza A (H1N1) 2009, and the association between age and RIDT sensitivity was determined. Results Of 1373 specimens examined, 269 tested positive for influenza A(H1N1) 2009 by real-time RT-PCR (rRT-PCR) and had RIDT results available. Overall clinical sensitivity and specificity of RIDTs were 53?9 and 98?5%, respectively. By age group, clinical sensitivity was 85?7% in patients <2 years old, 60?3% in patients between 2- and 39 years old, and 33?3% in patients aged 40 and older. Logistic regression analysis indicated that increasing age was negatively associated with RIDT performance. Conclusion Rapid influenza diagnostic test sensitivity decreased significantly with increasing age. Findings from this study may impact a clinician's interpretation of RIDT test results and ultimately have implications in clinical decision-making.
? 2011 Blackwell Publishing Ltd.
PMID:
22114876
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22114876
Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests.
Gao F, Loring C, Laviolette M, Bolton D, Daly ER, Bean C.
Source
Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, NH, USA.
Abstract
Please cite this paper as: Gao et al. (2011) Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00313.x. Background The performance of rapid influenza diagnostic tests (RIDTs) in detecting influenza A(H1N1) 2009 has varied widely. Evaluations of RIDTs among infected individuals across all age groups have not been described in depth. Objectives Determine RIDT clinical sensitivity in comparison with influenza detection using real-time RT-PCR among patients infected with influenza A(H1N1) 2009 across all age groups. Study design This study analyzed respiratory specimens received by the New Hampshire Public Health Laboratories (NHPHL) from September 1, 2009, through December 31, 2009. RIDT performance was evaluated among different age groups of patients determined to be infected with influenza A (H1N1) 2009, and the association between age and RIDT sensitivity was determined. Results Of 1373 specimens examined, 269 tested positive for influenza A(H1N1) 2009 by real-time RT-PCR (rRT-PCR) and had RIDT results available. Overall clinical sensitivity and specificity of RIDTs were 53?9 and 98?5%, respectively. By age group, clinical sensitivity was 85?7% in patients <2 years old, 60?3% in patients between 2- and 39 years old, and 33?3% in patients aged 40 and older. Logistic regression analysis indicated that increasing age was negatively associated with RIDT performance. Conclusion Rapid influenza diagnostic test sensitivity decreased significantly with increasing age. Findings from this study may impact a clinician's interpretation of RIDT test results and ultimately have implications in clinical decision-making.
? 2011 Blackwell Publishing Ltd.
PMID:
22114876
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22114876