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Editor, Senior Moderator
Detecting transmission and reassortment events for influenza A viruses with genotype profile method
Changzheng Dong, Liya Ying and Dongfang Yuan
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Virology Journal 2011, 8:395 doi:10.1186/1743-422X-8-395
Published: 9 August 2011
Abstract (provisional)
Evolutionary events of transmission and reassortment for influenza A viruses were traditionally detected by phylogenetic analysis for influenza viruses' eight gene segments. Because the phylogenetic analysis can be complex, we developed genotype profile method which packaged the phylogenetic algorithms to analyze combination patterns of gene segments and integrated epidemiology knowledge. With the method, the analysis of reassortment and transmission becomes a simple and reliable process that combines genotypes, which is identical for the biological process of the virus. An application called IVEE that implements the method is available for all academic users to apply the method (http://snptransformer.sourceforge.net). Furthermore, we found that a previous summary of the reassortment events in swine influenza A viruses may be inaccurate.
http://www.virologyj.com/content/pdf/1743-422X-8-395.pdf
Changzheng Dong, Liya Ying and Dongfang Yuan
For all author emails, please log on.
Virology Journal 2011, 8:395 doi:10.1186/1743-422X-8-395
Published: 9 August 2011
Abstract (provisional)
Evolutionary events of transmission and reassortment for influenza A viruses were traditionally detected by phylogenetic analysis for influenza viruses' eight gene segments. Because the phylogenetic analysis can be complex, we developed genotype profile method which packaged the phylogenetic algorithms to analyze combination patterns of gene segments and integrated epidemiology knowledge. With the method, the analysis of reassortment and transmission becomes a simple and reliable process that combines genotypes, which is identical for the biological process of the virus. An application called IVEE that implements the method is available for all academic users to apply the method (http://snptransformer.sourceforge.net). Furthermore, we found that a previous summary of the reassortment events in swine influenza A viruses may be inaccurate.
http://www.virologyj.com/content/pdf/1743-422X-8-395.pdf