tetano
Editor, Senior Moderator
Clinical Infectious Diseases
Detecting 2009 Pandemic Influenza A (H1N1) Virus Infection: Availability of Diagnostic Testing Led to Rapid Pandemic Response
1. D. B. Jernigan1,
2. S .L. Lindstrom1,
3. J .R. Johnson4,
4. J.D. Miller1,
5. M. Hoelscher1,
6. R. Humes5,
7. R. Shively6,
8. L. Brammer1,
9. S. A. Burke4,
10. J. M. Villanueva4,
11. A. Balish1,
12. T. Uyeki1,
13. D. Mustaquim1,
14. A. Bishop1,
15. J. H. Handsfield2,
16. R. Astles3,
17. X. Xu1,
18. A. I. Klimov1,
19. N. J. Cox1, and
20. M. W. Shaw1
+ Author Affiliations
1.
1Influenza Division, National Center for Immunization and Respiratory Diseases
2.
2Division of Preparedness and Emerging Infections, National Center for Enteric, Zoonotic, and Infectious Diseases
3.
3Division of Laboratory Science and Standards, Office of Surveillance, Epidemiology and Laboratory Services, Centers for Disease Control and Prevention
4.
4Battelle CDC Operations, Atlanta, GA
5.
5Association of Public Health Laboratories, Silver Spring, MD
6.
6Biomedical Advanced Research and Development Authority, Department of Health and Human Services, Washington, DC
1. Correspondence: Daniel B. Jernigan, M.D., MPH, Centers for Disease Control and Prevention, Mailstop A-20, 1600 Clifton Rd, Atlanta, GA 30333 (dbj0@cdc.gov).
Abstract
Diagnostic tests for detecting emerging influenza virus strains with pandemic potential are critical for directing global influenza prevention and control activities. In 2008, the Centers for Disease Control and Prevention received US Food and Drug Administration approval for a highly sensitive influenza polymerase chain reaction (PCR) assay. Devices were deployed to public health laboratories in the United States and globally. Within 2 weeks of the first recognition of 2009 pandemic influenza H1N1, the Centers for Disease Control and Prevention developed and began distributing a new approved pandemic influenza H1N1 PCR assay, which used the previously deployed device platform to meet a >8-fold increase in specimen submissions. Rapid antigen tests were widely used by clinicians at the point of care; however, test sensitivity was low (40%?69%). Many clinical laboratories developed their own pandemic influenza H1N1 PCR assays to meet clinician demand. Future planning efforts should identify ways to improve availability of reliable testing to manage patient care and approaches for optimal use of molecular testing for detecting and controlling emerging influenza virus strains.
http://cid.oxfordjournals.org/content/52/suppl_1/S36.full
Detecting 2009 Pandemic Influenza A (H1N1) Virus Infection: Availability of Diagnostic Testing Led to Rapid Pandemic Response
1. D. B. Jernigan1,
2. S .L. Lindstrom1,
3. J .R. Johnson4,
4. J.D. Miller1,
5. M. Hoelscher1,
6. R. Humes5,
7. R. Shively6,
8. L. Brammer1,
9. S. A. Burke4,
10. J. M. Villanueva4,
11. A. Balish1,
12. T. Uyeki1,
13. D. Mustaquim1,
14. A. Bishop1,
15. J. H. Handsfield2,
16. R. Astles3,
17. X. Xu1,
18. A. I. Klimov1,
19. N. J. Cox1, and
20. M. W. Shaw1
+ Author Affiliations
1.
1Influenza Division, National Center for Immunization and Respiratory Diseases
2.
2Division of Preparedness and Emerging Infections, National Center for Enteric, Zoonotic, and Infectious Diseases
3.
3Division of Laboratory Science and Standards, Office of Surveillance, Epidemiology and Laboratory Services, Centers for Disease Control and Prevention
4.
4Battelle CDC Operations, Atlanta, GA
5.
5Association of Public Health Laboratories, Silver Spring, MD
6.
6Biomedical Advanced Research and Development Authority, Department of Health and Human Services, Washington, DC
1. Correspondence: Daniel B. Jernigan, M.D., MPH, Centers for Disease Control and Prevention, Mailstop A-20, 1600 Clifton Rd, Atlanta, GA 30333 (dbj0@cdc.gov).
Abstract
Diagnostic tests for detecting emerging influenza virus strains with pandemic potential are critical for directing global influenza prevention and control activities. In 2008, the Centers for Disease Control and Prevention received US Food and Drug Administration approval for a highly sensitive influenza polymerase chain reaction (PCR) assay. Devices were deployed to public health laboratories in the United States and globally. Within 2 weeks of the first recognition of 2009 pandemic influenza H1N1, the Centers for Disease Control and Prevention developed and began distributing a new approved pandemic influenza H1N1 PCR assay, which used the previously deployed device platform to meet a >8-fold increase in specimen submissions. Rapid antigen tests were widely used by clinicians at the point of care; however, test sensitivity was low (40%?69%). Many clinical laboratories developed their own pandemic influenza H1N1 PCR assays to meet clinician demand. Future planning efforts should identify ways to improve availability of reliable testing to manage patient care and approaches for optimal use of molecular testing for detecting and controlling emerging influenza virus strains.
http://cid.oxfordjournals.org/content/52/suppl_1/S36.full