tetano
Editor, Senior Moderator
Molecules. 2012 Aug 10;17(8):9590-620.
Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses <sup>?</sup>.
Nohara T, Imamura A, Yamaguchi M, Hidari KI, Suzuki T, Komori T, Ando H, Ishida H, Kiso M.
Source
Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan. aimamura@gifu-u.ac.jp.
Abstract
A novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neua2-3 and 2-6 type viruses.
PMID:
22885358
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22885358
Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses <sup>?</sup>.
Nohara T, Imamura A, Yamaguchi M, Hidari KI, Suzuki T, Komori T, Ando H, Ishida H, Kiso M.
Source
Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan. aimamura@gifu-u.ac.jp.
Abstract
A novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neua2-3 and 2-6 type viruses.
PMID:
22885358
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22885358