tetano
Editor, Senior Moderator
Antivir Chem Chemother. 2016 Mar 27. pii: 2040206616636992. [Epub ahead of print]
[h=1]Derivatives of usnic acid inhibit broad range of influenza viruses and protect mice from lethal influenza infection.[/h] Shtro AA[SUP]1[/SUP], Zarubaev VV[SUP]2[/SUP], Luzina OA[SUP]3[/SUP], Sokolov DN[SUP]3[/SUP], Salakhutdinov NF[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is a disease of significant morbidity and mortality, the number of anti-influenza drugs is small; many of them stimulate the appearance of resistant strains. In this work, we demonstrate activity of some usnic acid (UA) derivatives against influenza virus in vitro and in vivo.
[h=4]METHODS:[/h] Organic synthesis was used to prepare compounds. Antiviral activity of the compounds in vitro was evaluated by their ability to decrease the virus titer on Madin-Darby Canine Kidney cells. In vivo activity was evaluated by decrease of mortality and index of protection.
[h=4]RESULTS:[/h] Compounds were tested against a broad spectrum of influenza virus strains and showed activity against all used strains. One compound, [5] (valine enamine of UA), also significantly reduced lethality of infected animals and does not give rise to the appearance of resistant strains. Additional studies showed that hepatotoxicity of compound [5] is reduced comparatively to UA.
[h=4]CONCLUSION:[/h] Our results suggest that valine enamine of UA could be a potential candidate for the development of a new anti-influenza therapy.
? The Author(s) 2016.
[h=4]KEYWORDS:[/h] Compounds; influenza; inhibitors; orthomyxoviridae; respiratory infections
PMID: 27022094 [PubMed - as supplied by publisher]
[h=1]Derivatives of usnic acid inhibit broad range of influenza viruses and protect mice from lethal influenza infection.[/h] Shtro AA[SUP]1[/SUP], Zarubaev VV[SUP]2[/SUP], Luzina OA[SUP]3[/SUP], Sokolov DN[SUP]3[/SUP], Salakhutdinov NF[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is a disease of significant morbidity and mortality, the number of anti-influenza drugs is small; many of them stimulate the appearance of resistant strains. In this work, we demonstrate activity of some usnic acid (UA) derivatives against influenza virus in vitro and in vivo.
[h=4]METHODS:[/h] Organic synthesis was used to prepare compounds. Antiviral activity of the compounds in vitro was evaluated by their ability to decrease the virus titer on Madin-Darby Canine Kidney cells. In vivo activity was evaluated by decrease of mortality and index of protection.
[h=4]RESULTS:[/h] Compounds were tested against a broad spectrum of influenza virus strains and showed activity against all used strains. One compound, [5] (valine enamine of UA), also significantly reduced lethality of infected animals and does not give rise to the appearance of resistant strains. Additional studies showed that hepatotoxicity of compound [5] is reduced comparatively to UA.
[h=4]CONCLUSION:[/h] Our results suggest that valine enamine of UA could be a potential candidate for the development of a new anti-influenza therapy.
? The Author(s) 2016.
[h=4]KEYWORDS:[/h] Compounds; influenza; inhibitors; orthomyxoviridae; respiratory infections
PMID: 27022094 [PubMed - as supplied by publisher]