Re: Denmark - Dane with novel H1N1 found resistant to Tamiflu
Dane first with H1N1-mutation
29. June 2009 15:58
A Dane has developed a mutated version of H1N1 that are resistant to influenza agent Tamiflu. This is the first identified mutation of H1N1 in the world
The first case in the world of resistance to influenza drug Tamiflu in people with influenza H1N1 has been found in Denmark. The person is now healthy, and there is no further evidence of infection with resistant virus, according to Statens Serum Institut.
- We do not expect that it exists long, says Nils Strandberg Pedersen, Managing Director, Statens Serum Institut, and refers to the mutated form of H1N1.
The infected Dane had been in close contact with another infected person, and was therefore prevented treatment with Tamiflu. Yet the person had flu symptoms and are instead treated with another type of flu drugs, Relenza.
According to Niels Strandberg Pedersen, it is not significant that the first mutated version is found in Denmark.
- We see it as an expression of our monitoring work, he said.
World Health Organization Calls for the Danish case for more attention to the possibility of development of resistance in the virus.
It is not unusual for a flu virus mutating spontaneously and in a press release calls the Statens Serum Institut is "well known and expected." At the same time, Niels Strandberg Pedersen not exclude that there will be new forms of mutation.
For the treatment of H1N1, Denmark has large stockpiles of Tamiflu, and in late April were purchased 40,000 doses of Relenza for additional security in cases of resistant mutations.
http://www.kristeligt-dagblad.dk/artikel/329568:Danmark--Dansker-den-foerste-med-H1N1-mutation
Dansker den f?rste med H1N1-mutation
29. jun 2009 15:58 En dansker har udviklet en muteret udgave af H1N1, der er resistent over for influenzamidlet Tamiflu. Det er den f?rste konstaterede mutation af H1N1 i verden
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Det f?rste tilf?lde i verden af resistens over for influenzamedicinen Tamiflu hos folk med influenza H1N1 er fundet i Danmark. Personen er nu rask, og der er ikke p?vist yderligere smitte med det resistente virus, oplyser Statens Serum Institut.
- Vi regner ikke med, at det eksisterer l?ngere, siger Nils Strandberg Pedersen, der er administrerende direkt?r ved Statens Serum Institut, og henviser til den muterede form af H1N1.
Den smittede dansker havde v?ret i t?t kontakt med en anden smittet person og var derfor i forebyggede behandling med Tamiflu. Alligevel fik personen influenzasymptomer og er i stedet behandlet med en anden type influenzamedicin, Relenza.
If?lge Niels Strandberg Pedersen er det ikke af betydning, at den f?rste muterede version er fundet i Danmark.
- Vi opfatter det som et udtryk for, at vores overv?gninger fungerer, siger han.
Verdens sundhedsorganisationen WHO opfordrer efter det danske tilf?lde til mere opm?rksomhed p? mulighed for udvikling af resistens hos viruset.
Det er ikke us?dvanligt, at en influenzavirus muterer spontant, og i en pressemeddelelse kalder Statens Serum Institut det "Velkendt og forventeligt." Samtidig kan Niels Strandberg Pedersen ikke udelukke, at der vil komme nye former for mutation.
Til behandling af H1N1 har Danmark store lagre af Tamiflu, og i slutningen af april blev der indk?bt 40.000 doser Relenza som en ekstra sikkerhed i tilf?lde af resistente mutationer.
