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DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

sharon sanders

Editor-in-Chief & President
hat tip to Fla Medic -

by FT Resident and Flu Wiki Founder DemfromCT:

Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?



From the Free Dictionary:
pan·dem·ic (pn-dmk) adj.

  1. Widespread; general.

  1. Medicine Epidemic over a wide geographic area and affecting a large proportion of the population: pandemic influenza.
June 11, 2009, Margaret Chan, Director General of the World Health Organization:
On the basis of available evidence, and these expert assessments of the evidence, the scientific criteria for an influenza pandemic have been met.
I have therefore decided to raise the level of influenza pandemic alert from phase 5 to phase 6.
The world is now at the start of the 2009 influenza pandemic.
When we write about flu here, there are still a remarkable number of comments to the tune of "it's not a pandemic, why are you scaring people?" or "why do you spend so much time on this?"
Well, besides the fact that I'm interested in the topic, it happens that pandemics affect a lot of people in a lot of ways great and small, and any such topic is worth spending time on. But it's not that folks don't know about it. There's just a certain amount of complacency about flu and vaccinations.
In a new survey, Harvard School of Public Health (HSPH) researchers found that just 40% of adults are "absolutely certain" they will get the H1N1 vaccine for themselves, and 51% of parents are "absolutely certain" that they will get the vaccine for their children. The survey examined the reasoning among those who said they would not get the vaccine or might not.
But none of that is written in stone.
If there were people in their community who were sick or dying from H1N1, roughly six in ten adults (59%) who say they do not think they'll get the vaccine would change their mind and get it for themselves. About the same percentage of parents (60%) who say they do not think they'll get the vaccine for their children would change their minds if H1N1 was causing sickness or death in their community.
"These findings suggest that public health officials need to be prepared for a surge in demand for the H1N1 vaccine if the H1N1 flu becomes more severe," said Robert J. Blendon, Professor of Health Policy and Political Analysis at HSPH.
It's not hard to find stories of people getting sick or dying of flu, though as of now it's not that widespread in every community. We don't have specific data on whether vaccine rates are higher in Dallas or Atlanta, which have higher rates of influenza-like illness than New England or the mid-Atlantic states. The good news on that, at least for the second wave of illness we may be peaking.

That would be a good thing, though we don't know if we are yet, and we can't predict whether there'll be a third wave in a few months. But health authorities are only now coming to grips with vaccine resistance from the public, and a report here or there from a death really won't make a dent in that (but more would, and the death of a child is a variable different than the death of a senior.) What to expect, therefore, is a varying demand for vaccine, which will start to become available in most states over the next two weeks (and be more readily available by end October.)
From the WaPo:
Part of the reason for the tepid enthusiasm may be that the vaccine campaign is being buffeted by political and social currents: wariness of mainstream medicine combined with suspicion of big government and a general unease and complacency about vaccines. Together, these trends have sparked a flood of misconceptions about the vaccine's safety and effectiveness, as well as about supposed plans to make the vaccine mandatory.
"There's a lot of misinformation out there," said Gregory Poland, a flu vaccine expert at the Mayo Clinic. "Then you mix into that people's concerns about conspiracy theories and government misbehavior and conflicts of interest and all of that, and the average layperson has a difficult time discerning what to do."...
Although the new H1N1 virus generally causes mild illness, most people have no immunity against it, meaning far more people will probably become infected, sick, end up in the hospital and possibly die than during a usual flu season. Most disturbingly, children, young adults and pregnant women appear to be especially vulnerable.
There's room on line for anyone and everyone, but high risk people (pregnant women, under 24, 25-64 with chronic health conditions and health care workers) need to be at the head of the line.
Now, in addition to that being a reason for a major on-going vaccination program, the logistics of which will consume public health folks for the next few weeks (public health infrastructure!!!), the other two aspects of flu news have to to do with two major reports released this week, one by Brookings on the cost of school closures and the other by Trust For America's Health on the capacity of states to handle illness in 35% of the population.
Both topics have been discussed here before (see H1N1: Why Do Schools Close, And When Do They Open? from May, 2009, and Hospital Surge, Exercises and Pandemics from April 2008.) The issues covered in those posts are good background for the reports issued this week.
More below the fold

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As of right now, the severity of this particular pandemic does not call for widespread and prolonged school closure. Brookings issued a report on the billions it would cost for prolonged and sustained school closures.
We give estimates of both the direct economic and health care impacts for school closure durations of 2, 4, 8, and 12 weeks under a range of assumptions. We find that closing all schools in the U.S. for four weeks could cost between $10 and $47 billion dollars (0.1-0.3% of GDP) and lead to a reduction of 6% to 19% in key health care personnel. These should be considered conservative (i.e., low) economic estimates in that earnings rather than total compensation are used to calculate costs. We also provide per student costs, so regionally heterogeneous policies can be evaluated. These estimates permit the epidemiological benefits of school closure to be compared to the costs at multiple scales and over many durations.
Back in May we wrote: The more severe the pandemic, the longer the schools will stay closed.

It remains a tool in the toolbox, albeit an expensive one to use. You'll see spot closures when things get intense locally:
After a two-day closure due to an increase in flu-related absences among its students and staff, Huntsville Independent School District [Texas] opened its doors Thursday to a significant decrease in absences.
If the widespread flu seen in Texas hits elsewhere, the same scenarios may also play out elsewhere:
Swine Flu Hot Spots
Southern U.S. First to Battle Deadly Flu
As the nation braces for flu season and a potential outbreak of swine flu, the South already appears to be dealing with a wave of H1N1 cases, setting up tents to deal with hundreds of possibly infected children each day.
As TFAH notes:
15 states could run out of available hospital beds during the peak of the outbreak, if 35 percent of Americans were to get sick from the H1N1 flu virus. Twelve additional states could reach or exceed 75 percent of their hospital bed capacity, based on estimates from the FluSurge model developed by the U.S. Centers for Disease Control and Prevention (CDC). The report, H1N1 Challenges Ahead, estimates that the number of people hospitalized could range from a high of 168,025 in California to a low of 2,485 in Wyoming, and many states may face shortages of beds or may need to reduce the number of non-flu related discretionary hospitalizations due to limited hospital bed availability. The numbers of people who get sick could range from a high of 12.9 million in California to a low of 186,434 in Wyoming, if 35 percent of Americans were to get H1N1.
It's for that reason that surge exercises have been run, and surge planning has taken place for several years now, dating back to 2005 when the National Strategy for Pandemic Influenza was released. And quoting myself from 2008,
"This isn’t just about us, it’s about our neighborhoods and where we live."
None of the above is about fear, it's about planning (much of which you don't have to do, and some of which you do.) And for right now, the planning you most need to consider is whether you will participate in a voluntary flu vaccine program designed to mitigate further waves of illness, and protect the vulnerable you come in contact with.
For example:
Health officials say that pregnant women should be among the first to get the new vaccine.
But they know it will be an uphill battle persuading some people -- even those who are at high risk -- to take it.
"With vaccines, you're asking a currently healthy person to do something to prevent a future harm," said Dr. Greg Poland, a Mayo Clinic expert in pandemic flu and infectious diseases. "To me, it's an easy decision. But I recognize not everybody would feel that way."
Recognize that the baseline is 8% vaccination for pregnant women (6 million pregnancies and half a million vaccinated.) Tripling that gets us up to 24%, still pretty low.
You can find more information here at flu.gov and at cdc.gov.
No black helicopters here. Just advice you need to hear.
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

in Georgia it peaked one week earlier, in some regions there is
still almost nothing.
You can see the charts of 10 US-regions also on the CDC-webpage,
the national chart is just the (weighted) sum of those.
And regional charts include several states, several counties
which often have differently looking charts again.

Best should be to look at city-flu-charts.
I assume that they should show the waves and peaks more clearly.

Unless there are countermeasures like school-closures etc.

make the wave-charts of 1000 big cities worldwide and see,
how the wave travels ! Or just the peak-dates.
Make a computer animation. Take into account the amount
of traffic between any of those cities.
Compare with theoretical,computed,modelled spread
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

why do waves peak and go down again ?
Weather ? Doesn't seeam to match, it would also be less
uniform, not the typical : 5 weeks up, 5 weeks down.

So it goes down when enough people were infected
and are immune now. But that sort of wave-immunity
only lasts ~2months - then we often see a new
wave starting already.

Only ~10% are infected in a typical seasonal wave,
yet these are sufficient to make the wave go down.
So a city with 10% alrady infected is different from a city
which is just 10% less densely populated !
The other 90% are less likely to get it.
Immunity of superspreaders is enough ?
Or the other 90% inhale the virus without getting sick
and develope some unknown sort of resistance
undetected by serology ?
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

Worth noting here that Google Flu Trends ( http://www.google.org/flutrends/intl/en_us/ ) and the CDC have not only departed company in recent weeks, they are barely even in the same solar system. Well at least for some States. Oklahoma and Texas for instance were tracking each other but now Oklahoma is still in line with Google but Texas has turned down according to the official figures.

okili38.png


However if we look into the Texas figures we see the following.

Google Flu Trends insists that Texas has the highest flu activity in the US at the moment and we know that ER visits have reached such a high level that "Flu Tents" have been set up outside some hospitals.

Yet according to Texas ili figures the rate dropped from 6.7 to 5.5% last week. In comparison Oklahoma official figures increased from 6.4 to 10.4 over the same week (much in line with Google Flu trends).

Now if I look at http://www.dshs.state.tx.us/idcu/disease/influenza/surveillance/2009/ I see that only 38 providers returned ili data last week in Texas. The number of providers has fallen from the normal level of around 80 to 38 (8 providers dropped out last week alone). Also the number of cases in 0-4 age dropped from 228 last week to 46 this week. Something seems very wrong with these numbers. Have they just cut out the bad news from the report?

===================

Now on top of this we have local tv reports from San Antonio stating that the actual ILI rate for Bexar County is 23% (of visits to a doctor) or possibly 40% or possibly just confused.

See http://www.woai.com/content/news/H1...r-County-have-flu/2JBHdLUpW0KP8AZaDI4DkQ.cspx

txilitv.jpg



Also news from Sept 24th at http://www.kens5.com/news/health/stories/KENS20090923-SwineFluLatest.1ac421d3f.html
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

Now if I look at http://www.dshs.state.tx.us/idcu/disease/influenza/surveillance/2009/ I see that only 38 providers returned ili data last week in Texas. The number of providers has fallen from the normal level of around 80 to 38 (8 providers dropped out last week alone). Also the number of cases in 0-4 age dropped from 228 last week to 46 this week. Something seems very wrong with these numbers. Have they just cut out the bad news from the report?

More likely is that those providers not reporting are swamped with ili patients and do not have time or energy to tally and submit the numbers. They may have office staff ill as well.
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

The descrapancy in numbers is quite large - perhaps associated with late returns of data, and these numbers will be adjusted shortlly? Also looking at the data state by state on the Google applicaion, there are several examples where the data point levelled off (or even appeared to turn down) only to accelerate upwards at the next data point.

As such, perhpas we can only start to comment on the discrepancy when the next data point is in for the CDC graph, and we can compare then? They may have more lag time in the data than Google has? Worth watching closely.
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

Flu is not a reportable illness. And, doctors sometimes report death by pneumonia or some other disease rather than flu.
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

More likely is that those providers not reporting are swamped with ili patients and do not have time or energy to tally and submit the numbers. They may have office staff ill as well.
I was thinking the very same thing. I wouldn't be surprised if we saw a decreasing trend in the percentage of sentinal providers reporting as the severity of the pandemic increased in a given region/state/city. If those not reporting are the ones who are the most stressed due to increased illness, then the %ILI data would be biased in favor of lower %ILI. That is why I am skeptical that %ILI charts are telling the full story. At this point, school absentee rates might be a better indicator.
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

. . . At this point, school absentee rates might be a better indicator.

I agree with this, providing we all can get some real time updates on absentee rates in local schools.
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

Here's some realtime data from Seton Hospitals (Austin) Tweet

http://twitter.com/setonh1n1

# Some decrease yest down to 314 patients. Doubt this represents a true decrease in ILI more likely due to the rain. Very busy today..all ILI
-about 1 hour ago from web

# First local statistically significant spikes in flu/ILI in those over 25 years old now starting to appear. Get immunized when available.
-8:19 AM Oct 4th from web

==

Here's an update from Texas Children's Hosipital

http://www.click2houston.com/health/21202620/detail.html#story

All Visitors Must Be Over 12, Show No Flu-Like Symptoms

POSTED: Monday, October 5, 2009
UPDATED: 7:03 am CDT October 5, 2009
HOUSTON -- Texas Children's Hospital has changed its visitor policy because of the flu outbreak, KPRC Local 2 reported Monday.

The hospital will only allow visitors over the age of 12, and no one will be allowed to visit if they show any flu-like symptoms. Any visitors showing flu-like symptoms will be asked to leave.

The policy took effect Monday and will be in place until further notice.

Texas is one of 27 states that has reported widespread flu outbreaks.

The new H1N1 vaccine has been sent out and is expected to be available in some locations on Tuesday or Wednesday. Those wishing to get the vaccine are urged to check with their medical provider to see if they are eligible to receive the vaccine and when it will be available.

=====

Video news report at above link

"Texas Children's Hospital has been flooded with people seeking help for the flu."
 
Re: DemfromCT - Pandemic Influenza: 2009 H1N1 And The Peak of The Second Wave?

I think a big problem with using school absences is that parents will withdraw their well children when the novel H1N1 flu hits with the excuse that they are sick to avoid truancy issues.
 
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