tetano
Editor, Senior Moderator
Vaccine. 2020 Jan 13. pii: S0264-410X(20)30004-9. doi: 10.1016/j.vaccine.2020.01.002. [Epub ahead of print] [h=1]Decreased ratio of influenza-specific IgG versus IgM in response to influenza vaccination in antiretroviral-treated HIV-infected African Americans compared to Caucasians, and its direct correlation with the percentages of peripheral Tfh cells.[/h]
Ma P[SUP]1[/SUP], Luo Z[SUP]2[/SUP], Qian J[SUP]3[/SUP], Yan Z[SUP]3[/SUP], Zhang L[SUP]4[/SUP], Martin L[SUP]5[/SUP], Wang Z[SUP]3[/SUP], Xia H[SUP]3[/SUP], Yu F[SUP]3[/SUP], Jiang W[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Racial differences have been observed in the rate of bacterial infection and disease progression in HIV. Here, we evaluate racial differences in seasonal influenza vaccine responses.
[h=4]METHODS:[/h] 16 healthy controls (9 Caucasians (CC) and 7 African Americans (AA)) and 26 antiretroviral therapy (ART)-treated aviremic HIV+ subjects (11 CC and 15 AA) were enrolled in the current study. Blood was collected at pre-vaccination (D0) and day 14 (D14) following seasonal influenza vaccination. Serologic responses were characterized in plasma by ELISA. B and T cells were assessed by flow cytometry ex vivo.
[h=4]RESULTS:[/h] The absolute counts of CD4+ CD3+ T cells and CD19+ B cells were similar in healthy controls and HIV-infected individuals, and similar in CC and AA in the two study groups. However, the percentage of peripheral T follicular helper (pTfh) cells was decreased in HIV+ AA compared to HIV+ CC. There were no racial differences in IgG antibody responses against vaccination in the two study groups. However, the ratio of anti-influenza-specific IgG versus IgM induction following vaccination was decreased in HIV+ AA compared to HIV+ CC, which was directly correlated with the percentages of pTfh cells. This racial difference and correlation were not demonstrable in healthy controls.
[h=4]CONCLUSION:[/h] Here we report that HIV + AA has decreased fold induction of IgG versus IgM after influenza vaccination, which may suggest impaired class-switching from IgM to IgG in AA HIV-infected individuals.
Copyright ? 2020. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antibody responses; B cells; HIV disease; Influenza vaccine
PMID: 31948820 DOI: 10.1016/j.vaccine.2020.01.002
Ma P[SUP]1[/SUP], Luo Z[SUP]2[/SUP], Qian J[SUP]3[/SUP], Yan Z[SUP]3[/SUP], Zhang L[SUP]4[/SUP], Martin L[SUP]5[/SUP], Wang Z[SUP]3[/SUP], Xia H[SUP]3[/SUP], Yu F[SUP]3[/SUP], Jiang W[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Racial differences have been observed in the rate of bacterial infection and disease progression in HIV. Here, we evaluate racial differences in seasonal influenza vaccine responses.
[h=4]METHODS:[/h] 16 healthy controls (9 Caucasians (CC) and 7 African Americans (AA)) and 26 antiretroviral therapy (ART)-treated aviremic HIV+ subjects (11 CC and 15 AA) were enrolled in the current study. Blood was collected at pre-vaccination (D0) and day 14 (D14) following seasonal influenza vaccination. Serologic responses were characterized in plasma by ELISA. B and T cells were assessed by flow cytometry ex vivo.
[h=4]RESULTS:[/h] The absolute counts of CD4+ CD3+ T cells and CD19+ B cells were similar in healthy controls and HIV-infected individuals, and similar in CC and AA in the two study groups. However, the percentage of peripheral T follicular helper (pTfh) cells was decreased in HIV+ AA compared to HIV+ CC. There were no racial differences in IgG antibody responses against vaccination in the two study groups. However, the ratio of anti-influenza-specific IgG versus IgM induction following vaccination was decreased in HIV+ AA compared to HIV+ CC, which was directly correlated with the percentages of pTfh cells. This racial difference and correlation were not demonstrable in healthy controls.
[h=4]CONCLUSION:[/h] Here we report that HIV + AA has decreased fold induction of IgG versus IgM after influenza vaccination, which may suggest impaired class-switching from IgM to IgG in AA HIV-infected individuals.
Copyright ? 2020. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antibody responses; B cells; HIV disease; Influenza vaccine
PMID: 31948820 DOI: 10.1016/j.vaccine.2020.01.002