tetano
Editor, Senior Moderator
Data Brief
. 2023 Jun;48:109158.
doi: 10.1016/j.dib.2023.109158. Epub 2023 Apr 19.
Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
A O Kovalenko[SUP] 1 [/SUP], E M Ryabchevskaya[SUP] 1 [/SUP], E A Evtushenko[SUP] 1 [/SUP], O A Kondakova[SUP] 1 [/SUP], P A Ivanov[SUP] 1 [/SUP], M V Arkhipenko[SUP] 1 [/SUP], N A Nikitin[SUP] 1 [/SUP], O V Karpova[SUP] 1 [/SUP]
Affiliations
Abstract
This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses' S protein fragments and a structurally modified plant virus - spherical particles. The effectiveness of the experimental vaccines was studied against the SARS-CoV-2 virus in an in vivo infection model in female Syrian hamsters. The body weight of vaccinated laboratory animals was monitored. The histological assessment data of the infected with the SARS-CoV-2 virus hamsters' lungs are provided.
Keywords: COVID-19; Lung histological studies; Preclinical study; Spherical particles; Structurally modified plant virus; Vaccine; Vaccine protective efficacy.
. 2023 Jun;48:109158.
doi: 10.1016/j.dib.2023.109158. Epub 2023 Apr 19.
Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
A O Kovalenko[SUP] 1 [/SUP], E M Ryabchevskaya[SUP] 1 [/SUP], E A Evtushenko[SUP] 1 [/SUP], O A Kondakova[SUP] 1 [/SUP], P A Ivanov[SUP] 1 [/SUP], M V Arkhipenko[SUP] 1 [/SUP], N A Nikitin[SUP] 1 [/SUP], O V Karpova[SUP] 1 [/SUP]
Affiliations
- PMID: 37095758
- PMCID: PMC10113597
- DOI: 10.1016/j.dib.2023.109158
Abstract
This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses' S protein fragments and a structurally modified plant virus - spherical particles. The effectiveness of the experimental vaccines was studied against the SARS-CoV-2 virus in an in vivo infection model in female Syrian hamsters. The body weight of vaccinated laboratory animals was monitored. The histological assessment data of the infected with the SARS-CoV-2 virus hamsters' lungs are provided.
Keywords: COVID-19; Lung histological studies; Preclinical study; Spherical particles; Structurally modified plant virus; Vaccine; Vaccine protective efficacy.