tetano
Editor, Senior Moderator
Ageing Res Rev. 2015 Jul 19. pii: S1568-1637(15)30007-6. doi: 10.1016/j.arr.2015.07.005. [Epub ahead of print]
[h=1]DAMPs and Influenza Virus Infection in Ageing.[/h] Hsiu RP[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) is a serious global health problem worldwide due to frequent and severe outbreaks. IAV causes significant morbidity and mortality in the elderly population, due to the ineffectiveness of the vaccine and the alteration of T cell immunity with ageing. The cellular and molecular link between ageing and virus infection is unclear and it is possible that damage associated molecular patterns (DAMPs) may play a role in the raised severity and susceptibility of virus infections in the elderly. DAMPs which are released from damaged cells following activation, injury or cell death can activate the immune response through the stimulation of the inflammasome through several types of receptors found on the plasma membrane, inside endosomes after endocytosis as well as in the cytosol. In this review, the detriment in the immune system during aging and the links between influenza virus infection and ageing will be discussed. In addition, the role of DAMPs such as HMGB1 and S100/Annexin in ageing, and will in the enhanced morbidity and mortality to severe influenza infection in ageing will be highlighted.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Ageing; DAMPs; Influenza A virus; alarmins; nuclear factor kappa B; pro-inflammatory cytokines; toll-like receptors
PMID: 26200296 [PubMed - as supplied by publisher]
[h=1]DAMPs and Influenza Virus Infection in Ageing.[/h] Hsiu RP[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) is a serious global health problem worldwide due to frequent and severe outbreaks. IAV causes significant morbidity and mortality in the elderly population, due to the ineffectiveness of the vaccine and the alteration of T cell immunity with ageing. The cellular and molecular link between ageing and virus infection is unclear and it is possible that damage associated molecular patterns (DAMPs) may play a role in the raised severity and susceptibility of virus infections in the elderly. DAMPs which are released from damaged cells following activation, injury or cell death can activate the immune response through the stimulation of the inflammasome through several types of receptors found on the plasma membrane, inside endosomes after endocytosis as well as in the cytosol. In this review, the detriment in the immune system during aging and the links between influenza virus infection and ageing will be discussed. In addition, the role of DAMPs such as HMGB1 and S100/Annexin in ageing, and will in the enhanced morbidity and mortality to severe influenza infection in ageing will be highlighted.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Ageing; DAMPs; Influenza A virus; alarmins; nuclear factor kappa B; pro-inflammatory cytokines; toll-like receptors
PMID: 26200296 [PubMed - as supplied by publisher]