tetano
Editor, Senior Moderator
Cytotherapy
. 2021 Sep 2;S1465-3249(21)00741-6.
doi: 10.1016/j.jcyt.2021.07.006. Online ahead of print.
Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains
Maja Stanojevic[SUP] 1 [/SUP], Ashley Geiger[SUP] 1 [/SUP], Brita Ostermeier[SUP] 2 [/SUP], Danielle Sohai[SUP] 1 [/SUP], Christopher Lazarski[SUP] 1 [/SUP], Haili Lang[SUP] 1 [/SUP], Mariah Jensen-Wachspress[SUP] 1 [/SUP], Kathleen Webber[SUP] 1 [/SUP], Peter Burbelo[SUP] 3 [/SUP], Jeffrey Cohen[SUP] 4 [/SUP], Michael D Keller[SUP] 1 [/SUP], Catherine M Bollard[SUP] 5 [/SUP], Conrad Russell Y Cruz[SUP] 6 [/SUP]
Affiliations
Abstract
Although most studies describing coronavirus disease 2019 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here the authors evaluated T-cell responses in seronegative donors before and after vaccination to define responses to the severe acute respiratory syndrome coronavirus 2 reference strain as well as to mutations in the variant strains Alpha/B.1.1.7 and Beta/B.1.351. The authors observed enhanced T-cell responses to reference and variant spike strains post-vaccination.
Keywords: COVID-19 variants; SARS-CoV-2; T-cell responses to coronavirus; vaccination.
. 2021 Sep 2;S1465-3249(21)00741-6.
doi: 10.1016/j.jcyt.2021.07.006. Online ahead of print.
Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains
Maja Stanojevic[SUP] 1 [/SUP], Ashley Geiger[SUP] 1 [/SUP], Brita Ostermeier[SUP] 2 [/SUP], Danielle Sohai[SUP] 1 [/SUP], Christopher Lazarski[SUP] 1 [/SUP], Haili Lang[SUP] 1 [/SUP], Mariah Jensen-Wachspress[SUP] 1 [/SUP], Kathleen Webber[SUP] 1 [/SUP], Peter Burbelo[SUP] 3 [/SUP], Jeffrey Cohen[SUP] 4 [/SUP], Michael D Keller[SUP] 1 [/SUP], Catherine M Bollard[SUP] 5 [/SUP], Conrad Russell Y Cruz[SUP] 6 [/SUP]
Affiliations
- PMID: 34483067
- DOI: 10.1016/j.jcyt.2021.07.006
Abstract
Although most studies describing coronavirus disease 2019 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here the authors evaluated T-cell responses in seronegative donors before and after vaccination to define responses to the severe acute respiratory syndrome coronavirus 2 reference strain as well as to mutations in the variant strains Alpha/B.1.1.7 and Beta/B.1.351. The authors observed enhanced T-cell responses to reference and variant spike strains post-vaccination.
Keywords: COVID-19 variants; SARS-CoV-2; T-cell responses to coronavirus; vaccination.