tetano
Editor, Senior Moderator
Vaccine. 2012 Nov 26. pii: S0264-410X(12)01648-9. doi: 10.1016/j.vaccine.2012.11.041. [Epub ahead of print]
Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.
Derhovanessian E, Theeten H, H?hnel K, Van Damme P, Cools N, Pawelec G.
Source
Department of Internal Medicine II, Centre for Medical Research, University of T?bingen, 72072 T?bingen, Germany. Electronic address: evelyna.derhovanessian@klinikum.uni-tuebingen.de.
Abstract
Influenza vaccination is less effective in the elderly compared to the young. Studies that have attempted to identify immune parameters correlating with satisfactory vaccine responses have yielded inconclusive results. Here, we correlate the distribution of different circulating CD4+ and CD8+ T-cell phenotypes with the humoral response to vaccination with Intanza, an intradermal seasonal vaccine, in 54 individuals of different ages. Subjects were stratified according to age (below or over 60) and presence of a latent infection with Cytomegalovirus (CMV). CMV-seropositivity was significantly associated with a lower response rate to the vaccine in people over but not below 60yr of age. Unlike reported data, late-differentiated (CD45RA+CCR7-CD27-CD2
CD4+, but not CD8+, T-cells associated with a poorer vaccine response. Thus, latent CMV infection has a deleterious effect on influenza antibody responses in the elderly, which might be mediated through CD4 T-cells lacking CCR7, CD27 and CD28 and re-expressing CD45RA.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
23196209
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23196209
Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.
Derhovanessian E, Theeten H, H?hnel K, Van Damme P, Cools N, Pawelec G.
Source
Department of Internal Medicine II, Centre for Medical Research, University of T?bingen, 72072 T?bingen, Germany. Electronic address: evelyna.derhovanessian@klinikum.uni-tuebingen.de.
Abstract
Influenza vaccination is less effective in the elderly compared to the young. Studies that have attempted to identify immune parameters correlating with satisfactory vaccine responses have yielded inconclusive results. Here, we correlate the distribution of different circulating CD4+ and CD8+ T-cell phenotypes with the humoral response to vaccination with Intanza, an intradermal seasonal vaccine, in 54 individuals of different ages. Subjects were stratified according to age (below or over 60) and presence of a latent infection with Cytomegalovirus (CMV). CMV-seropositivity was significantly associated with a lower response rate to the vaccine in people over but not below 60yr of age. Unlike reported data, late-differentiated (CD45RA+CCR7-CD27-CD2
CD4+, but not CD8+, T-cells associated with a poorer vaccine response. Thus, latent CMV infection has a deleterious effect on influenza antibody responses in the elderly, which might be mediated through CD4 T-cells lacking CCR7, CD27 and CD28 and re-expressing CD45RA.Copyright ? 2012. Published by Elsevier Ltd.
PMID:
23196209
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23196209