tetano
Editor, Senior Moderator
Cytokine
. 2023 Feb 16;165:156163.
doi: 10.1016/j.cyto.2023.156163. Online ahead of print.
T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
Jeffrey S Putter[SUP] 1 [/SUP], Jerard Seghatchian[SUP] 2 [/SUP]
Affiliations
Abstract
Purpose of the research: We proposed T-cell lymphocytopenia as a strategic predictor of serious coronavirus and influenza infections. Our preeminent goal was to determine whether a degree of T-cell lymphopenia would identify a distinct threshold cell count to differentiate between severe and non-severe infections. We codified an Index Severity Score to exploit an association between T-cell cytopenia and the grade of disease activity.
Principal result: A T-cell count of 560 cells/uL or below signified a trend towards advanced disease.
Keywords: Index Severity Score of infection; Influenza virus; SARS-CoV disease; T-cell apoptosis and sequestration; T-cell differential counts; T-cell lymphocytopenia.
. 2023 Feb 16;165:156163.
doi: 10.1016/j.cyto.2023.156163. Online ahead of print.
T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
Jeffrey S Putter[SUP] 1 [/SUP], Jerard Seghatchian[SUP] 2 [/SUP]
Affiliations
- PMID: 36989654
- DOI: 10.1016/j.cyto.2023.156163
Abstract
Purpose of the research: We proposed T-cell lymphocytopenia as a strategic predictor of serious coronavirus and influenza infections. Our preeminent goal was to determine whether a degree of T-cell lymphopenia would identify a distinct threshold cell count to differentiate between severe and non-severe infections. We codified an Index Severity Score to exploit an association between T-cell cytopenia and the grade of disease activity.
Principal result: A T-cell count of 560 cells/uL or below signified a trend towards advanced disease.
Keywords: Index Severity Score of infection; Influenza virus; SARS-CoV disease; T-cell apoptosis and sequestration; T-cell differential counts; T-cell lymphocytopenia.