tetano
Editor, Senior Moderator
J Infect Dis. 2018 Sep 5. doi: 10.1093/infdis/jiy535. [Epub ahead of print]
[h=1]Cytokine Profiles and Severity of Influenza Infection in Transplant Recipients.[/h] L'Huillier AG[SUP]1[/SUP], Ferreira VH[SUP]1[/SUP], Hirzel C[SUP]1[/SUP], Cordero E[SUP]2[/SUP], Limaye AP[SUP]3[/SUP], Reid G[SUP]4[/SUP], Englund J[SUP]5[/SUP], Blumberg E[SUP]6[/SUP], Kumar D[SUP]1[/SUP], Humar A[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza is responsible for significant morbidity after transplantation. We evaluated Th1/Th2 cytokines and IL-10 levels during influenza infection in the post-transplant setting. Sera from 277 transplant recipients were analyzed at influenza diagnosis and 28 days later for IFN-γ, IL-4, IL-13 and IL-10. IL-13 levels were associated with protection against pneumonia and ICU admission, whereas the IFN-γ/IL-13 ratio and IL-10 levels were associated with an increased risk of pneumonia and ICU admission. This association was independent of viral load. A skewing of immune responses towards Th2 in transplant patients appears to confer protection from severe influenza infection, independently of viral load.
PMID: 30192949 DOI: 10.1093/infdis/jiy535
[h=1]Cytokine Profiles and Severity of Influenza Infection in Transplant Recipients.[/h] L'Huillier AG[SUP]1[/SUP], Ferreira VH[SUP]1[/SUP], Hirzel C[SUP]1[/SUP], Cordero E[SUP]2[/SUP], Limaye AP[SUP]3[/SUP], Reid G[SUP]4[/SUP], Englund J[SUP]5[/SUP], Blumberg E[SUP]6[/SUP], Kumar D[SUP]1[/SUP], Humar A[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza is responsible for significant morbidity after transplantation. We evaluated Th1/Th2 cytokines and IL-10 levels during influenza infection in the post-transplant setting. Sera from 277 transplant recipients were analyzed at influenza diagnosis and 28 days later for IFN-γ, IL-4, IL-13 and IL-10. IL-13 levels were associated with protection against pneumonia and ICU admission, whereas the IFN-γ/IL-13 ratio and IL-10 levels were associated with an increased risk of pneumonia and ICU admission. This association was independent of viral load. A skewing of immune responses towards Th2 in transplant patients appears to confer protection from severe influenza infection, independently of viral load.
PMID: 30192949 DOI: 10.1093/infdis/jiy535