tetano
Editor, Senior Moderator
Cytokine
. 2021 Mar 31;155523.
doi: 10.1016/j.cyto.2021.155523. Online ahead of print.
Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity
Yueting Tang[SUP] 1 [/SUP], Jiayu Sun[SUP] 2 [/SUP], Huaqin Pan[SUP] 3 [/SUP], Fen Yao[SUP] 4 [/SUP], Yumeng Yuan[SUP] 5 [/SUP], Mi Zeng[SUP] 6 [/SUP], Guangming Ye[SUP] 7 [/SUP], Gui Yang[SUP] 8 [/SUP], Bokun Zheng[SUP] 9 [/SUP], Junli Fan[SUP] 10 [/SUP], Yunbao Pan[SUP] 11 [/SUP], Ziwu Zhao[SUP] 12 [/SUP], Shuang Guo[SUP] 13 [/SUP], Yinjuan Liu[SUP] 14 [/SUP], Fanlu Liao[SUP] 15 [/SUP], Yongwei Duan[SUP] 16 [/SUP], Xiaoyang Jiao[SUP] 17 [/SUP], Yirong Li[SUP] 18 [/SUP]
Affiliations
Abstract
Cytokines play pleiotropic, antagonistic, and collaborative in viral disease. The high morbidity and mortality of coronavirus disease 2019 (COVID-19) make it a significant threat to global public health. Elucidating its pathogenesis is essential to finding effective therapy. A retrospective study was conducted on 71 patients hospitalized with COVID-19. Data on cytokines, T lymphocytes, and other clinical and laboratory characteristics were collected from patients with variable disease severity. The effects of cytokines on the overall survival (OS) and event-free survival (EFS) of patients were analyzed. The critically severe and severe patients had higher infection indexes and significant multiple organ function abnormalities than the mild patients (P < 0.05). IL-6 and IL-10 were significantly higher in the critically severe patients than in the severe and mild patients (P < 0.05). IL-6 and IL-10 were closely associated with white blood cells, neutrophils, T lymphocyte subsets, D-D dimer, blood urea nitrogen, complement C1q, procalcitonin C-reactive protein. Moreover, the IL-6 and IL-10 levels were closely correlated to dyspnea and dizziness (P < 0.05). The patients with higher IL-10 levels had shorter OS than the group with lower levels (P < 0.05). The older patients with higher levels of single IL-6 or IL-10 tended to have shorter EFS (P < 0.05), while the patients who had more elevated IL-6 and IL-10 had shorter OS (P < 0.05). The Cox proportional hazard model revealed that IL-6 was the independent factor affecting EFS. IL-6 and IL-10 play crucial roles in COVID-19 prognosis.
Keywords: COVID-19; Cytokines; Disease severity; Survival; T lymphocyte.
. 2021 Mar 31;155523.
doi: 10.1016/j.cyto.2021.155523. Online ahead of print.
Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity
Yueting Tang[SUP] 1 [/SUP], Jiayu Sun[SUP] 2 [/SUP], Huaqin Pan[SUP] 3 [/SUP], Fen Yao[SUP] 4 [/SUP], Yumeng Yuan[SUP] 5 [/SUP], Mi Zeng[SUP] 6 [/SUP], Guangming Ye[SUP] 7 [/SUP], Gui Yang[SUP] 8 [/SUP], Bokun Zheng[SUP] 9 [/SUP], Junli Fan[SUP] 10 [/SUP], Yunbao Pan[SUP] 11 [/SUP], Ziwu Zhao[SUP] 12 [/SUP], Shuang Guo[SUP] 13 [/SUP], Yinjuan Liu[SUP] 14 [/SUP], Fanlu Liao[SUP] 15 [/SUP], Yongwei Duan[SUP] 16 [/SUP], Xiaoyang Jiao[SUP] 17 [/SUP], Yirong Li[SUP] 18 [/SUP]
Affiliations
- PMID: 33840589
- DOI: 10.1016/j.cyto.2021.155523
Abstract
Cytokines play pleiotropic, antagonistic, and collaborative in viral disease. The high morbidity and mortality of coronavirus disease 2019 (COVID-19) make it a significant threat to global public health. Elucidating its pathogenesis is essential to finding effective therapy. A retrospective study was conducted on 71 patients hospitalized with COVID-19. Data on cytokines, T lymphocytes, and other clinical and laboratory characteristics were collected from patients with variable disease severity. The effects of cytokines on the overall survival (OS) and event-free survival (EFS) of patients were analyzed. The critically severe and severe patients had higher infection indexes and significant multiple organ function abnormalities than the mild patients (P < 0.05). IL-6 and IL-10 were significantly higher in the critically severe patients than in the severe and mild patients (P < 0.05). IL-6 and IL-10 were closely associated with white blood cells, neutrophils, T lymphocyte subsets, D-D dimer, blood urea nitrogen, complement C1q, procalcitonin C-reactive protein. Moreover, the IL-6 and IL-10 levels were closely correlated to dyspnea and dizziness (P < 0.05). The patients with higher IL-10 levels had shorter OS than the group with lower levels (P < 0.05). The older patients with higher levels of single IL-6 or IL-10 tended to have shorter EFS (P < 0.05), while the patients who had more elevated IL-6 and IL-10 had shorter OS (P < 0.05). The Cox proportional hazard model revealed that IL-6 was the independent factor affecting EFS. IL-6 and IL-10 play crucial roles in COVID-19 prognosis.
Keywords: COVID-19; Cytokines; Disease severity; Survival; T lymphocyte.