tetano
Editor, Senior Moderator
Curr Top Med Chem. 2020 May 16. doi: 10.2174/1568026620999200517043137. [Epub ahead of print]
Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery.
Sternberg A[SUP]1[/SUP], McKee DL[SUP]2[/SUP], Naujokat C[SUP]3[/SUP].
Author information
Abstract
Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARSCoV- 2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit spread of SARS-CoV-2 and morbidity and mortality of the COVID-19 pandemic.
Copyright? Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
KEYWORDS:
3Clpro; COVID-19; Camostat; Coronavirus SARS-CoV-2; RNA polymerase; Remdesivir; S protein; α-Ketoamides.
PMID:32416679DOI:10.2174/1568026620999200517043137
Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery.
Sternberg A[SUP]1[/SUP], McKee DL[SUP]2[/SUP], Naujokat C[SUP]3[/SUP].
Author information
Abstract
Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARSCoV- 2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit spread of SARS-CoV-2 and morbidity and mortality of the COVID-19 pandemic.
Copyright? Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
KEYWORDS:
3Clpro; COVID-19; Camostat; Coronavirus SARS-CoV-2; RNA polymerase; Remdesivir; S protein; α-Ketoamides.
PMID:32416679DOI:10.2174/1568026620999200517043137