tetano
Editor, Senior Moderator
Curr Res Pharmacol Drug Discov
. 2021 Dec 4;100072.
doi: 10.1016/j.crphar.2021.100072. Online ahead of print.
Strategies for drug repurposing against coronavirus targets
Poppy O Smith[SUP] 1 [/SUP], Peiqin Jin[SUP] 1 [/SUP], Khondaker Miraz Rahman[SUP] 1 [/SUP]
Affiliations
Abstract
Repurposing regulatory agency approved drugs and investigational compounds with known safety profiles can significantly fast track the drug development timeline over de novo drug discovery, with lower investment requirements and improved attrition rate. These advantages are vital in any epidemic or pandemic situation, where hospital beds are occupied by patients for whom there is no known treatment. Here we examine drug repurposing in the context of human coronaviruses, SARS-CoV, MERS-CoV, and, in particular, SARS-CoV-2, the virus currently causing a continued widespread pandemic with substantial impacts on public health and economy. The key druggable targets explored were those involved in viral entry, viral replication, and viral-induced ARDS, as well as viral proteases, with a focus on the strategy by which the drugs were repurposed.
Keywords: Coronavirus; Drug repurposing; In silico screening; SARS-CoV-2.
. 2021 Dec 4;100072.
doi: 10.1016/j.crphar.2021.100072. Online ahead of print.
Strategies for drug repurposing against coronavirus targets
Poppy O Smith[SUP] 1 [/SUP], Peiqin Jin[SUP] 1 [/SUP], Khondaker Miraz Rahman[SUP] 1 [/SUP]
Affiliations
- PMID: 34901833
- PMCID: PMC8642829
- DOI: 10.1016/j.crphar.2021.100072
Abstract
Repurposing regulatory agency approved drugs and investigational compounds with known safety profiles can significantly fast track the drug development timeline over de novo drug discovery, with lower investment requirements and improved attrition rate. These advantages are vital in any epidemic or pandemic situation, where hospital beds are occupied by patients for whom there is no known treatment. Here we examine drug repurposing in the context of human coronaviruses, SARS-CoV, MERS-CoV, and, in particular, SARS-CoV-2, the virus currently causing a continued widespread pandemic with substantial impacts on public health and economy. The key druggable targets explored were those involved in viral entry, viral replication, and viral-induced ARDS, as well as viral proteases, with a focus on the strategy by which the drugs were repurposed.
Keywords: Coronavirus; Drug repurposing; In silico screening; SARS-CoV-2.