tetano
Editor, Senior Moderator
Curr Pediatr Rev
. 2020 Nov 11.
doi: 10.2174/1573396316666201112093920. Online ahead of print.
COVID-19 and Comorbidities: is Inflammation the Underlying Condition in Children? A narrative Review
Giulia Pinna[SUP] 1 [/SUP], Lavinia Sanfilippo[SUP] 1 [/SUP], Pier Paolo Bassareo[SUP] 2 [/SUP], Vassilios Fanos[SUP] 1 [/SUP], Maria Antonietta Marcialis[SUP] 1 [/SUP]
Affiliations
Abstract
This paper examines the potential link between COVID-19 and the presence of comorbidities and assesses the role of inflammation in this correlation. In COVID-19 patients, the most frequently associated diseases share a pathogenic inflammatory basis and apparently act as a risk factor in the onset of a more severe form of the disease, particularly in adulthood. However, in children, the understanding of the underlying pathogenic mechanisms is often complicated by the milder symptoms presented. A series of theories have therefore been put forward with a view of providing a better understanding of the role played by inflammation in this dramatic setting. All evidence available to date on this topic is discussed in this review.
Keywords: COVID-19; children; coronavirus; inflammation; pathogenic; risk factors.
. 2020 Nov 11.
doi: 10.2174/1573396316666201112093920. Online ahead of print.
COVID-19 and Comorbidities: is Inflammation the Underlying Condition in Children? A narrative Review
Giulia Pinna[SUP] 1 [/SUP], Lavinia Sanfilippo[SUP] 1 [/SUP], Pier Paolo Bassareo[SUP] 2 [/SUP], Vassilios Fanos[SUP] 1 [/SUP], Maria Antonietta Marcialis[SUP] 1 [/SUP]
Affiliations
- PMID: 33183207
- DOI: 10.2174/1573396316666201112093920
Abstract
This paper examines the potential link between COVID-19 and the presence of comorbidities and assesses the role of inflammation in this correlation. In COVID-19 patients, the most frequently associated diseases share a pathogenic inflammatory basis and apparently act as a risk factor in the onset of a more severe form of the disease, particularly in adulthood. However, in children, the understanding of the underlying pathogenic mechanisms is often complicated by the milder symptoms presented. A series of theories have therefore been put forward with a view of providing a better understanding of the role played by inflammation in this dramatic setting. All evidence available to date on this topic is discussed in this review.
Keywords: COVID-19; children; coronavirus; inflammation; pathogenic; risk factors.