tetano
Editor, Senior Moderator
Curr Opin Virol
. 2024 Mar 7:65:101397.
doi: 10.1016/j.coviro.2024.101397. Online ahead of print. Tissue-resident memory T cells in protective immunity to influenza virus
Seungwoo Lee[SUP] 1 [/SUP], Karen Km Yeung[SUP] 1 [/SUP], Tania H Watts[SUP] 2 [/SUP]
Affiliations
Influenza virus is an important human pathogen with significant pandemic potential. Tissue-resident memory T cells (Trm) in the lung provide critical protection against influenza, but unlike Trm at other mucosal sites, Trm in the respiratory tract (RT) are subject to rapid attrition in mice, mirroring the decline in protective immunity to influenza virus over time. Conversely, dysfunctional Trm can drive fibrosis in aged mice. The requirement for local antigen to induce and maintain RT Trm must be considered in vaccine strategies designed to induce this protective immune subset. Here, we discuss recent studies that inform our understanding of influenza-specific respiratory Trm, and the factors that influence their development and persistence. We also discuss how these biological insights are being used to develop vaccines that induce Trm in the RT, despite the limitations to monitoring Trm in humans.
. 2024 Mar 7:65:101397.
doi: 10.1016/j.coviro.2024.101397. Online ahead of print. Tissue-resident memory T cells in protective immunity to influenza virus
Seungwoo Lee[SUP] 1 [/SUP], Karen Km Yeung[SUP] 1 [/SUP], Tania H Watts[SUP] 2 [/SUP]
Affiliations
- PMID: 38458064
- DOI: 10.1016/j.coviro.2024.101397
Influenza virus is an important human pathogen with significant pandemic potential. Tissue-resident memory T cells (Trm) in the lung provide critical protection against influenza, but unlike Trm at other mucosal sites, Trm in the respiratory tract (RT) are subject to rapid attrition in mice, mirroring the decline in protective immunity to influenza virus over time. Conversely, dysfunctional Trm can drive fibrosis in aged mice. The requirement for local antigen to induce and maintain RT Trm must be considered in vaccine strategies designed to induce this protective immune subset. Here, we discuss recent studies that inform our understanding of influenza-specific respiratory Trm, and the factors that influence their development and persistence. We also discuss how these biological insights are being used to develop vaccines that induce Trm in the RT, despite the limitations to monitoring Trm in humans.