tetano
Editor, Senior Moderator
Curr Opin Pharmacol
. 2021 Dec 21;62:152-158.
doi: 10.1016/j.coph.2021.12.006. Online ahead of print.
Molecular accuracy vs antigenic speed: SARS-CoV-2 testing strategies
Álvaro Fajardo[SUP] 1 [/SUP], Paula Perbolianachis[SUP] 1 [/SUP], Irene Ferreiro[SUP] 1 [/SUP], Pilar Moreno[SUP] 2 [/SUP], Gonzalo Moratorio[SUP] 3 [/SUP]
Affiliations
Abstract
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit every corner of the world faster than any infectious disease ever known. In this context, rapid and accurate testing of positive cases are essential to follow the test-trace-isolate strategy (TETRIS), which has proven to be a key approach to constrain viral spread. Here, we discuss how to interpret and combine molecular or/and antigen-based detection methods for SARS-CoV-2 as well as when they should be used. Their application can be cleverly designed as an algorithm to prevent viral dissemination according to distinct epidemiological contexts within surveillance programs.
Keywords: Antigenic test; RT-PCR; SARS-CoV-2; Testing strategies.
. 2021 Dec 21;62:152-158.
doi: 10.1016/j.coph.2021.12.006. Online ahead of print.
Molecular accuracy vs antigenic speed: SARS-CoV-2 testing strategies
Álvaro Fajardo[SUP] 1 [/SUP], Paula Perbolianachis[SUP] 1 [/SUP], Irene Ferreiro[SUP] 1 [/SUP], Pilar Moreno[SUP] 2 [/SUP], Gonzalo Moratorio[SUP] 3 [/SUP]
Affiliations
- PMID: 35042168
- DOI: 10.1016/j.coph.2021.12.006
Abstract
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit every corner of the world faster than any infectious disease ever known. In this context, rapid and accurate testing of positive cases are essential to follow the test-trace-isolate strategy (TETRIS), which has proven to be a key approach to constrain viral spread. Here, we discuss how to interpret and combine molecular or/and antigen-based detection methods for SARS-CoV-2 as well as when they should be used. Their application can be cleverly designed as an algorithm to prevent viral dissemination according to distinct epidemiological contexts within surveillance programs.
Keywords: Antigenic test; RT-PCR; SARS-CoV-2; Testing strategies.