tetano
Editor, Senior Moderator
Curr Opin Microbiol
. 2024 Mar 23:79:102455.
doi: 10.1016/j.mib.2024.102455. Online ahead of print. Host determinants and responses underlying SARS-CoV-2 liver tropism
Natalie Heinen[SUP] 1 [/SUP], Mara Klöhn[SUP] 1 [/SUP], Saskia Westhoven[SUP] 2 [/SUP], Richard Jp Brown[SUP] 3 [/SUP], Stephanie Pfaender[SUP] 4 [/SUP]
Affiliations
Hepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in liver autopsies and the susceptibility of explanted human hepatocytes to infection. In this review, we confirm that hepatic cells express an extensive range of factors implicated in SARS-CoV-2 entry. We also provide an overview of studies reporting evidence for direct infection of liver cell types and the infection-induced cell-intrinsic processes that likely contribute to hepatic impairment.
. 2024 Mar 23:79:102455.
doi: 10.1016/j.mib.2024.102455. Online ahead of print. Host determinants and responses underlying SARS-CoV-2 liver tropism
Natalie Heinen[SUP] 1 [/SUP], Mara Klöhn[SUP] 1 [/SUP], Saskia Westhoven[SUP] 2 [/SUP], Richard Jp Brown[SUP] 3 [/SUP], Stephanie Pfaender[SUP] 4 [/SUP]
Affiliations
- PMID: 38522265
- DOI: 10.1016/j.mib.2024.102455
Hepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in liver autopsies and the susceptibility of explanted human hepatocytes to infection. In this review, we confirm that hepatic cells express an extensive range of factors implicated in SARS-CoV-2 entry. We also provide an overview of studies reporting evidence for direct infection of liver cell types and the infection-induced cell-intrinsic processes that likely contribute to hepatic impairment.